US3903264A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antibiotic A-130-A and production thereof
Assignee: Shionogi and Co Ltd
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Filing: 1973-12-27
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Granted: 1975-09-02
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Expires: 1993-12-27
Abstract
Abstract A new antibiotic, A-130-A, being useful as a medicament for inhibiting the growth of gram-positive pathogenic microorganism and an anti-coccidial agent for poultry, and a process for preparing the same, being characterized by cultivating an A-130A-producing strain of microorganism belonging to the Genus Streptomyces in an aqueous nutrient containing medium under aerobic conditions.
Inventors
- 👤 Hiroshi Oikawa
- 👤 Harumoto Kawaguchi
- 👤 Yoshimi Kawamura
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 21:27
CPC Classifications
A; A61; A61K; A61K36/00; A61K36/06; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/886; Y10S435/898
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
40 words
AN ANTIBIOTIC, A-130-A, EFFECTIVE IN INHIBITING THE GROWTH OF GRAM-POSITIVE MICROOGRANISMS AND EIMERIA, THE SAID ANTIBIOTIC BEING A COLORLESS AMORPHOUS POWDER MELTING AT 87* TO 92*C, CONTAINING THE ELEMENTS CARBON, HYROGEN AND OXYGEN IN SUBSTANTIALLY THE FOLLOWING PROPORTIONS BY WEIGHT:
Claim 2
Dependent Claim
40 words
AN ANTIBIOTIC, A-130-A, EFFECTIVE IN INHIBITING THE GROWTH OF GRAM-POSITIVE MICROOGRANISMS AND EIMERIA, THE SAID ANTIBIOTIC BEING A COLORLESS AMORPHOUS POWDER MELTING AT 87* TO 92*C, CONTAINING THE ELEMENTS CARBON, HYROGEN AND OXYGEN IN SUBSTANTIALLY THE FOLLOWING PROPORTIONS BY WEIGHT:
Claim 3
Dependent Claim
43 words
An antibiotic, Na salt of A-130-A, effective in inhibiting the growth of gram-positivE microorganisms and Eimeria, the said antibiotic being a colorless needle like crystal melting at 227*-231*C containing the elements carbon, hydrogen, sodium and oxygen in substantially the following proportions by weight:
Claim 4
Dependent Claim
43 words
An antibiotic, Na salt of A-130-A, effective in inhibiting the growth of gram-positivE microorganisms and Eimeria, the said antibiotic being a colorless needle like crystal melting at 227*-231*C containing the elements carbon, hydrogen, sodium and oxygen in substantially the following proportions by weight:
Claim 5
Dependent Claim
113 words
A process for producing the antibiotic A-130-A as defined in claim 1, which comprises cultivating Streptomyces hygroscopicus A-130 (ATCC No. 21840) in an aqueous nutrient medium at a temperature from about 25* to about 45*C for about 20 to about 100 hours under aerobic conditions, adjusting the pH of the resultant culture broth to about 4.0, adding a filter aid to the culture broth, filtering the resultant culture broth, thus obtaining a filter cake containing a mixture of the filter aid and mycelium, and extracting the antibiotic A-130-A from the filter cake with a solvent selected from the group consisting of methanol, ethanol, acetone, chloroform, ether, methylene chloride, benzene, n-hexane and ethyl acetate.
Claim 6
Dependent Claim
48 words
The process according to claim 3, further comprising extracting the antibiotic A-130-A from the filtrate obtained during filtration with a solvent selected from the group consisting of methanol, ethanol, acetone, chloroform, ether, methylene chloride, benzene, n-hexane and ethyl acetate, to obtain an additional quantity of the antibiotic A-130-A.
Claim 7
Dependent Claim
50 words
A pharmaceutical composition for prophylaxis and treatment of avian coccidiosis, comprising an effective amount of the antibiotic A-130-A as defined in claim 1 for prophylaxis and treatment of avian coccidiosis in the free acid form, or its sodium salt, as an active ingredient in admixture with a pharmaceutically acceptable carrier.
Claim 8
Dependent Claim
29 words
A pharmaceutical composition according to claim 5, in which the amount of active ingredient is in the range from 0.001 weight % to 1.0 weight % of the composition.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-09-01 | 1979-03-03 | 1979-09-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-09-01 | 1983-03-03 | 1983-09-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-09-01 | 1987-03-03 | 1987-09-02 | $7700.00 | Window Closed / Lapsed |