US3902848A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Liquid chromatography detector and method
Assignee: Research Corp
•
Filing: 1974-06-26
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Granted: 1975-09-02
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Expires: 1994-06-26
Abstract
Abstract An extremely sensitive liquid chromatography detector is disclosed which detects solutes electrically through a direct spray technique. In operation effluent is sprayed from an aspirator at the outlet of the liquid chromatograph column onto a suitable target electrode, the varying potential or current generated providing a direct indication of trace amounts of eluted solute in the sprayed effluent. Accurate quantitative measurements may be made using the method and apparatus of the invention.
Inventors
- 👤 Jr Richard S Juvet
- 👤 Jr Richard A Mowery
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 17:41
CPC Classifications
G; G01; G01N; G01N30/00; G01N30/02; G01N30/62; G01N30/64; G01N30/84; G01N2030/8447; G01N2030/847; Y; Y10; Y10T; Y10T436/00; Y10T436/17; Y10T436/18; Y10T436/19; Y10T436/196666; Y10T436/21; Y10T436/214
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
34 words
A METHOD OF DETECTING A SOLUTE IN A LIQUID COMPRISING THE STEPS OF: SPRAYING SAID LIQUID ON A CONDUCTING MATERIAL, AND MEASURING AN ELECTRICAL SIGNAL PRODUCED IN SAID CONDUCTING MATERIAL FOR DETECTING SAID SOLUTE.
Claim 2
Independent Claim
34 words
A METHOD OF DETECTING A SOLUTE IN A LIQUID COMPRISING THE STEPS OF: SPRAYING SAID LIQUID ON A CONDUCTING MATERIAL, AND MEASURING AN ELECTRICAL SIGNAL PRODUCED IN SAID CONDUCTING MATERIAL FOR DETECTING SAID SOLUTE.
Claim 3
Dependent Claim
24 words
A method as in claim 1, further comprising the steps of: passing said liquid through a chromatographic column prior to said step of spraying.
Claim 4
Dependent Claim
44 words
A method as in claim 1, wherein said step of spraying includes the step of: developing an electrical signal in said conducting material through the phenomenon produced by a violent rupture of a liquid surface by the action of a gas, liquid, or solid.
Claim 5
Dependent Claim
25 words
A method as in claim 1, wherein said step of spraying includes the step of: propelling said liquid through a nozzle with a pressurized fluid.
Claim 6
Dependent Claim
36 words
A method as in claim 1, 1, wherein said step of measuring includes the steps of: sensing the electrical signal produced in said conducting material and continuously recording said electrical signal as a function of time.
Claim 7
Dependent Claim
99 words
A method as in claim 1, further comprising the steps of: injecting a sample of an unknown composition into a chromatographic column; separating said unknown composition into discrete solute components with said chromatographic column; supplying said separating discrete solute components to an aspirator prior to said step of spraying; supplying a pressurized propellant fluid to said aspirator to provide motive power for said step of spraying; continuously recording said electrical signal as a function of time to provide an output curve; and determining the quantitative contents of said separated solute components of said unknown composition from said output curve.
Claim 8
Independent Claim
60 words
An apparatus for detecting a solute in a liquid comprising: a conducting material; measuring means coupled to said conducting material for measuring a varying electrical signal produced therein; and, spray means positioned near said conducting material for spraying said liquid on said conducting material to develop said varying electrical signal in said conducting material for permitting detection of said solute.
Claim 9
Independent Claim
60 words
An apparatus for detecting a solute in a liquid comprising: a conducting material; measuring means coupled to said conducting material for measuring a varying electrical signal produced therein; and, spray means positioned near said conducting material for spraying said liquid on said conducting material to develop said varying electrical signal in said conducting material for permitting detection of said solute.
Claim 10
Dependent Claim
26 words
An apparatus as in claim 7, further comprising: chromographic column means coupled to said spray means for supplying compositionally separated solute components to said spray means.
Claim 11
Dependent Claim
24 words
An apparatus as in claim 7, further comprising: fluid pressure supply means coupled to spray means for providing a propelling force to said liquid.
Claim 12
Dependent Claim
15 words
An apparatus as in claim 7, wherein: said conducting material is comprised of glassy carbon.
Claim 13
Dependent Claim
14 words
An apparatus as in claim 7, wherein: said conducting material is comprised of gold.
Claim 14
Dependent Claim
17 words
An apparatus as in claim 7, wherein: said conducting material is comprised of gold plated on platinum.
Claim 15
Dependent Claim
21 words
An apparatus as in claim 7, further comprising: conducting material mounting means engaging said conducting material for insulating said conducting mateRial.
Claim 16
Dependent Claim
30 words
An apparatus as in claim 13, wherein said conducting material mounting means includes: a body portion; and, a head portion integral with said body portionn and containing said conducting material.
Claim 17
Dependent Claim
15 words
An apparatus as in claim 14, further comprising: noise reducing means included on said portion.
Claim 18
Dependent Claim
31 words
An apparatus as in claim 15, wherein said noise reducing means includes: means adjacent said head portion for preventing liquid droplets formed on said head portion from engaging said conducting material.
Claim 19
Dependent Claim
24 words
An apparatus as in claim 15, wherein: said means secured to said head portion includes a fiber for collecting and dispersing said liquid droplets.
Claim 20
Dependent Claim
28 words
An apparatus as in claim 15, wherein: said means adjacent to said head portion comprises a vacuum inlet for drawing said liquid droplets away from said conducting material.
Claim 21
Dependent Claim
23 words
An apparatus as in claim 7, wherein: said spray means comprises a nozzle structure having a liquid inlet and a pressurized fluid inlet.
Claim 22
Dependent Claim
44 words
An apparatus as in claim 19, further comprising: a source of pressurized fluid coupled to said nozzle for propelling said liquid through said nozzle; and, control means coupled to said source of pressurized fluid for regulating the pressure and flow rate of said fluid.
Claim 23
Dependent Claim
19 words
An apparatus as in claim 7, wherein: said measuring means includes an electrometer for measuring said varying electrical signal.
Claim 24
Dependent Claim
21 words
An apparatus as in claim 8, further comprising: mobile phase degassing means including a heated reservoir coupled to said chromatographic column.
References Cited (Backward Citations)
US3352643A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-09-01 | 1979-03-03 | 1979-09-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-09-01 | 1983-03-03 | 1983-09-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-09-01 | 1987-03-03 | 1987-09-02 | $7700.00 | Window Closed / Lapsed |