US3901928A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1' ,3' -dihydroxy steroid-5-enes method of preparing same and their use for preparing 1' -hydroxy-25-hydrogen vitamin d compounds
Assignee: Individual
•
Filing: 1973-05-21
•
Granted: 1975-08-26
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Expires: 1993-05-21
Abstract
Abstract 1 Alpha ,3 Beta -DIHYDROXY STEROID-5-ENES ARE PREPARED BY THE REDUCTION OF 1 Alpha -HYDROXY- AND 1 Alpha ,2 Alpha -EPOXYSTEROID-4,6-DIENE-3-ONES AND CORRESPONDING 6-SUBSTITUTED STEROID4-EN-3-ONES WHERE THE 6-SUBSTITUENT IS A REDUCTIVELY ELIMINATABLE ATOM OR GROUP WITH AN ALKALI METAL/LIQUID AMMONIA OR ALKALI METAL/LIQUID AMINE REDUCING AGENT IN THE PRESENCE OF A PROTON SOURCE. The conversion of such dihydroxylated steroids to therapeutically useful new 1 Alpha -hydroxy vitamin D derivatives and related compounds is also described, as are pharmaceutical compositions and applications of these new compounds.
Inventors
- 👤 Robert Henry Hesse
- 👤 Ezzio Rizzardo
- 👤 Derek Harold Richard Barton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 14:43
CPC Classifications
C; C07; C07C; C07C401/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
11 words
A PROCESS FOR THE PREPARTION OF A COMPOUND OF THE FORMULA
Claim 2
Dependent Claim
11 words
A PROCESS FOR THE PREPARTION OF A COMPOUND OF THE FORMULA
Claim 3
Dependent Claim
15 words
The process of claim 1 wherein the alkali metal of the reducing agent is lithium.
Claim 4
Dependent Claim
12 words
The process of claim 2 wherein the reducing agent is lithium/liquid Ammonia.
Claim 5
Dependent Claim
25 words
The process of claim 1 wherein if a 1 Alpha -hydroxylated starting material is employed, the 1 Alpha -hydroxy group is protected prior to reduction.
Claim 6
Dependent Claim
13 words
The process of claim 4 wherein said protecting groups is a trialkylsilyl group.
Claim 7
Dependent Claim
3 words
1 Alpha -Hydroxy-9,10-dihydrotachysterol.
Claim 8
Dependent Claim
3 words
1 Alpha -Hydroxy-9,10-dihydrotachysterol.
References Cited (Backward Citations)
US3741996A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-08-25 | 1979-02-24 | 1979-08-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-08-25 | 1983-02-24 | 1983-08-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-08-25 | 1987-02-24 | 1987-08-26 | $7700.00 | Window Closed / Lapsed |