US3901657A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Device for testing solutions and body fluids
Assignee: Sun Scientific Inc
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Filing: 1974-04-29
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Granted: 1975-08-26
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Expires: 1994-04-29
Abstract
Abstract A multi-layer device suitable for the colorimetric determination of the presence of a particular compound in a test solution is disclosed. The first layer contains an agent capable of concentrating the particular compound onto the surface of the layer, when the device is placed in a solution containing the particular compound. Subsequent reagent layers are incorporated as required to supply reagents, through diffusion, as needed to produce the end result of a color reaction on the first layer. Barrier layers may be incorporated between reagent layers. A new colorimetric method for the detection of morphine is also disclosed which may be adapted for use with the multi-layer device.
Inventors
- 👤 Charles L Lightfoot
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 06:58
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/52; G01N33/525; G01N33/94; G01N33/9486; Y; Y10; Y10S; Y10S436/00; Y10S436/901; Y10T; Y10T436/00; Y10T436/14; Y10T436/141111
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
53 words
A REACTIVE TEST DEVICE CAPABLE OF CONVERTING MORPHINE TO ACHROMOGENIC COMPOUND COMPRISING A FIRST PORTION INCLUDING A MORPHINOPHILIC AGENT AND A SECOND PORTION INCLUDING A PERIODATE REAGENT FOR MORPHINE CAPABLE OF RACTING WITH MORPHINE TO PRODUCE A CHROMOGENIC COMPOUND WHICH PRODUCES A VISUALLY OBSERVABLE COLOR AT A PH OF ABOUT 11 TO 13.
Claim 2
Dependent Claim
53 words
A REACTIVE TEST DEVICE CAPABLE OF CONVERTING MORPHINE TO ACHROMOGENIC COMPOUND COMPRISING A FIRST PORTION INCLUDING A MORPHINOPHILIC AGENT AND A SECOND PORTION INCLUDING A PERIODATE REAGENT FOR MORPHINE CAPABLE OF RACTING WITH MORPHINE TO PRODUCE A CHROMOGENIC COMPOUND WHICH PRODUCES A VISUALLY OBSERVABLE COLOR AT A PH OF ABOUT 11 TO 13.
Claim 3
Dependent Claim
31 words
The reactive test device of claim 1 further comprising a third portion including a color forming agent capable of reacting with the said chromogenic compound to produce a visually observable compound.
Claim 4
Dependent Claim
22 words
The reactive test device of claim 2 further comprising a non-reactive backing portion being at least substantially contiguous with the other portions.
Claim 5
Dependent Claim
22 words
The reactive test device of claim 3 wherein said backing portion includes a handle portion extending outward from said substantially contiguous portion.
Claim 6
Dependent Claim
39 words
The reactive test device of claim 2 wherein said morphinophilic agent is an acidic material, said periodate oxidizing agent is paraperiodic acid or its soluble salts and esters and pyridine and said color forming agent is a basic material.
Claim 7
Dependent Claim
118 words
A multi-portion test device suitable for the colorimetric detection of morphine in a solution by contact therewith comprising: a first portion containing a morphinophilic agent whereby morphine in a contacted solution is concentrated in said first portion; a second portion containing a reagent capable of converting morphine to a chromogenic compound, said reagent comprising pyridine and a compound selected from the group consisting of paraperiodic acid and its soluble salts and esters; and a third portion containing a strong base said portions being arranged whereby when the test device is contacted with the said solution, the reagent, base and reaction products thereof may permeate through all the portions to form a visually observable color on said first portion.
Claim 8
Dependent Claim
118 words
A multi-portion test device suitable for the colorimetric detection of morphine in a solution by contact therewith comprising: a first portion containing a morphinophilic agent whereby morphine in a contacted solution is concentrated in said first portion; a second portion containing a reagent capable of converting morphine to a chromogenic compound, said reagent comprising pyridine and a compound selected from the group consisting of paraperiodic acid and its soluble salts and esters; and a third portion containing a strong base said portions being arranged whereby when the test device is contacted with the said solution, the reagent, base and reaction products thereof may permeate through all the portions to form a visually observable color on said first portion.
Claim 9
Dependent Claim
19 words
The test device of claim 6 wherein at least one said portion is a strip of permeable, non-reactive material.
Claim 10
Dependent Claim
33 words
The test device of claim 7 wherein said test device further includes a rigid, impermeable material including a backing portion substantially contiguous with the said portions and a handle portion extending outwardly therefrom.
Claim 11
Dependent Claim
41 words
The test device of claim 6 wherein said morphinophilic agent is an acidic cationic exchange resin, said reagent capable of cOnverting morphine to a chromogenic compound is pyridine and paraperiodic acid and said strong base is sodium hydroxide or sodium methoxide.
Claim 12
Dependent Claim
48 words
A process for detecting morphine in a solution which comprises mixing said solution with a periodate reagent and pyridine to convert any morphine present to a chromogenic compound and contacting the resulting solution with a strong base to form a visually observable indication of the presence of morphine.
Claim 13
Dependent Claim
48 words
A process for detecting morphine in a solution which comprises mixing said solution with a periodate reagent and pyridine to convert any morphine present to a chromogenic compound and contacting the resulting solution with a strong base to form a visually observable indication of the presence of morphine.
Claim 14
Dependent Claim
12 words
The process of claim 10 wherein said solution is a urine solution.
Claim 15
Dependent Claim
17 words
The process of claim 10 wherein said periodate reagent is paraperiodic acid or its salts and esters.
Claim 16
Dependent Claim
15 words
The process of claim 12 wherein said strong base is sodium hydroxide or sodium methoxide.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-08-25 | 1979-02-24 | 1979-08-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-08-25 | 1983-02-24 | 1983-08-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-08-25 | 1987-02-24 | 1987-08-26 | $7700.00 | Window Closed / Lapsed |