US3900461A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Lymphocyte stroma adsorbent
Assignee: United States Department of Health and Human Services
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Filing: 1972-09-22
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Granted: 1975-08-19
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Expires: 1992-09-22
Abstract
Abstract A method of purifying antibodies against lymphocytes which consists of adsorbing and eluting purified antibody from an immunoadsorbent consisting of lymphocyte stroma conjugated to a cyanogen bromide activated cross-linked dextran polymer. The antibody is selected from a heterologous serum ALS, ATS, ALG, and ATG and the purified antibody product has significant immunosuppressive properties for prolonging graft survival while retaining humoral and cellular immunity to other foreign materials in the recipient. Further, the immunoadsorbent material provides a one-step preparative procedure. The immunoadsorbent has been found to be reusable for a period greater than 2 years.
Inventors
- 👤 Billie J Wilson
- 👤 Arthur Malley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 15:07
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/06; C07K16/065; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/58; A61K47/585
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
32 words
A REUSABLE IMMUNOADSORBENT FOR THE PURFICATION OF ANTIBODY AGAINST LYMPHOCYTES WHICH CONSISTS OF LYMPHOCYTE STROMA CONJUGATED TO A CYANOGEN BROMIDE ACTIVATED CROSSLINDED DEXTRAN POLYMER BASE WHEREIN SAID DEXTRAN IS CROSSLINKED WITH EPICHLOROHYDRIN.
Claim 2
Dependent Claim
32 words
A REUSABLE IMMUNOADSORBENT FOR THE PURFICATION OF ANTIBODY AGAINST LYMPHOCYTES WHICH CONSISTS OF LYMPHOCYTE STROMA CONJUGATED TO A CYANOGEN BROMIDE ACTIVATED CROSSLINDED DEXTRAN POLYMER BASE WHEREIN SAID DEXTRAN IS CROSSLINKED WITH EPICHLOROHYDRIN.
References Cited (Backward Citations)
US3105012A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-08-18 | 1979-02-17 | 1979-08-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-08-18 | 1983-02-17 | 1983-08-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-08-18 | 1987-02-17 | 1987-08-19 | $7700.00 | Window Closed / Lapsed |