US3899580A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anti-inflammatory topical gel
Assignee: Merck and Co Inc
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Filing: 1974-05-08
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Granted: 1975-08-12
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Expires: 1994-05-08
Abstract
Abstract Methods and compositions for topical application of an antiinflammatory agent selected from the group consisting of 2''-(4pyridyl)-6,16 Alpha -dimethyl-11 Beta ,17 Alpha ,21trihydroxypregna-4,6-dieno(3,2-c)-pyrazol-20-one, dexamethasone alcohol, prednisolone alcohol, and hydrocortisone alcohol in a clear water-white gel vehicle.
Inventors
- 👤 Joseph L O'neill
- 👤 Joseph V Bondi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 23:05
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/56; A61K31/58; A61K47/00; A61K47/06; A61K47/08; A61K47/10; A61K47/30; A61K47/36; A61K47/38; A61K9/00; A61K9/0012; A61K9/0014
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
95 words
A METHOD OF TREATING INFLAMMATION WHICH COMPRISES APPLYING TO THE SKIN A TOPICAL FORMULATION COMPRISING A THERAPEUTICALLY EFFECTIVE AMOUNT OF AN ANTI-INFLAMMATORY AGENT SELECTED FROM THE GROUP CONSISTING OF 2''-(4-PYRIDYL)-6,16ADIMETHYL-11B,17A,21-TRIHYDROXYPREGNA-4,6-DIENO-(3,2 -C)PYRAZOL-20-ONE, DEXAMETHASONE ALCOHOL PREDNISOLONE ALCOHOL AND HYDROCORTISONE ALCOHOL IN A CLEAR WATER-WHITE GEL CONSISTING OF 0.05 PERCENT BY WEIGHT OF DISODIUM EDETATE, FROM 8 TO 18 PERCENT BY WEIGHT OF WATER, FROM ABOUT 54 TO ABOUT 84 PERCENT BY WEIGHT OF A SOLVENT SELECTED FROM THE GROUP CONSISTING OF PROPYLENE GLYCOL AND MIXTURES THEREOF WITH ISOPROPYL ALCOHOL, AND 2.6 PERCENT BY WEIGHT OF HYDROXYPROPYL CELLULOSE.
Claim 2
Independent Claim
95 words
A METHOD OF TREATING INFLAMMATION WHICH COMPRISES APPLYING TO THE SKIN A TOPICAL FORMULATION COMPRISING A THERAPEUTICALLY EFFECTIVE AMOUNT OF AN ANTI-INFLAMMATORY AGENT SELECTED FROM THE GROUP CONSISTING OF 2''-(4-PYRIDYL)-6,16ADIMETHYL-11B,17A,21-TRIHYDROXYPREGNA-4,6-DIENO-(3,2 -C)PYRAZOL-20-ONE, DEXAMETHASONE ALCOHOL PREDNISOLONE ALCOHOL AND HYDROCORTISONE ALCOHOL IN A CLEAR WATER-WHITE GEL CONSISTING OF 0.05 PERCENT BY WEIGHT OF DISODIUM EDETATE, FROM 8 TO 18 PERCENT BY WEIGHT OF WATER, FROM ABOUT 54 TO ABOUT 84 PERCENT BY WEIGHT OF A SOLVENT SELECTED FROM THE GROUP CONSISTING OF PROPYLENE GLYCOL AND MIXTURES THEREOF WITH ISOPROPYL ALCOHOL, AND 2.6 PERCENT BY WEIGHT OF HYDROXYPROPYL CELLULOSE.
Claim 3
Dependent Claim
23 words
The method of claim 1 wherein the anti-inflammatory agent is 2''-(4-pyridyl)-6,16 Alpha -dimethyl-11 Beta ,17 Alpha ,21-trihydroxypregna-4,6-dieno-(3,2-c)-pyrazol-20-one, and the solvent is propylene glycol.
Claim 4
Dependent Claim
29 words
The method of claim 1 wherein the anti-inflammatory agent is 2''-(4-pyridyl)-6,16 Alpha -dimethyl-11 Beta ,17 Alpha ,21-trihydroxypregna-4,6-dieno-(3,2-c)-pyrazol-20-one, and the solvent is a mixture of isopropyl alcohol and propylene glycol.
Claim 5
Dependent Claim
21 words
The method of claim 3 wherein the isopropyl alcohol and propylene glycol solvent mixture is at a 0.5:1 to 0.6:1 ratio.
Claim 6
Dependent Claim
93 words
A topical formulation for treating inflammation which comprises a therapeutically effective amount of an anti-inflammatory agent selected from the group consisting of 2''-(4-pyridyl)-6,16 Alpha -dimethyl-11 Beta ,17 Alpha ,21-trihydroxypregna-4,6-dieno-(3,2-c)-pyrazol-20-one, dexamethasone alcohol, prednisolone alcohol and hydrocortisone alcohol in a clear water-white gel consisting of 0.05 percent by weight of disodium edetate, from 8 to 18 percent by weight of water, from about 54 to about 84 percent by weight of a solvent selected from the group consisting of propylene glycol and mixtures thereof with isopropyl alcohol, and 2.6 percent by weight of hydroxypropyl cellulose.
Claim 7
Dependent Claim
93 words
A topical formulation for treating inflammation which comprises a therapeutically effective amount of an anti-inflammatory agent selected from the group consisting of 2''-(4-pyridyl)-6,16 Alpha -dimethyl-11 Beta ,17 Alpha ,21-trihydroxypregna-4,6-dieno-(3,2-c)-pyrazol-20-one, dexamethasone alcohol, prednisolone alcohol and hydrocortisone alcohol in a clear water-white gel consisting of 0.05 percent by weight of disodium edetate, from 8 to 18 percent by weight of water, from about 54 to about 84 percent by weight of a solvent selected from the group consisting of propylene glycol and mixtures thereof with isopropyl alcohol, and 2.6 percent by weight of hydroxypropyl cellulose.
Claim 8
Dependent Claim
24 words
The composition of claim 5 wherein the anti-inflammatory agent is 2''-4(pyridyl)-6,16 Alpha -dimethyL-11 Beta ,17 Alpha , 21-trihydroxypregna-4,6-dieno-(3,2-c)-pyrazol-20-one, and the solvent is propylene glycol.
Claim 9
Dependent Claim
30 words
The composition of claim 5 wherein the anti-inflammatory agent is 2''-4(pyridyl)-6,16 Alpha -dimethyl-11 Beta ,17 Alpha , 21-trihydroxypregna-4,6-dieno-(3,2-c)-pryazol-20-one, and the solvent is a mixture of isopropyl alcohol and propylene glycol.
Claim 10
Dependent Claim
21 words
The composition of claim 7 wherein the isopropyl alcohol and propylene glycol solvent mixture is at a 0.5:1 to 0.6:1 ratio.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-08-11 | 1979-02-10 | 1979-08-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-08-11 | 1983-02-10 | 1983-08-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-08-11 | 1987-02-10 | 1987-08-12 | $7700.00 | Window Closed / Lapsed |