Method for administering water soluble drugs, nutrients and other solutes to a mammal

Claim 1

A METHOD FOR ADMINISTRATION OF SOLUTES TO A MAMMAL WHEREIN THE SOLUTES ARE MIXED IN AN AQUOUEOUS SOLUTION, CHARACTERIZED BY THE AQUEOUS SOLUTION HAVING AN OSMOLALITY IN MILLIOSMOLS/LITER OF 170 TO 460, PREFERABLY 260 TO 340, MORE PREFERABLY 290 TO 310 AND MOST PREFERABLY 300, A PH OF 7.0 AND 8.8 ND MORE PREFERABLY BETWEEN 7.5 AND 8.5, AND MOST PREFERABLY 8.1 AND FORMED OF COMPOUNDS HAVING AN ACTIVITY COEFFICIENT IN THE SOLUTION OF AT LEAST 0.8 AT 37*C TO PROVIDE CONCENTRATION IN MILLIOSMOLS/LITER OF NA* 75-200, PREFERABLY 85-150, MORE PREFERABLY 127-135 AND MOST PREFERABLY 131, OF K* 7-25, PREFERABLY 10-20, MORE PREFERABLY 131, OF K* 7-25, 14, OF MG** 3-8 AND PREFERABLY 5, OF HPO4= OR SO4= OR ACETATE OR GLUCONATE 3-8 AND PREFERABLY 5, OR HCO3 12-28, PREFERABLY 10-30, MORE PREFERABLY 16-20 AND MOST PREFERABLY 18 AND OF CI-70-195, PREFERABLY 85-185. MORE PFEFERABLY 124-130 AND MOST PREFERABLY 127.

Claim 2

A METHOD FOR ADMINISTRATION OF SOLUTES TO A MAMMAL WHEREIN THE SOLUTES ARE MIXED IN AN AQUOUEOUS SOLUTION, CHARACTERIZED BY THE AQUEOUS SOLUTION HAVING AN OSMOLALITY IN MILLIOSMOLS/LITER OF 170 TO 460, PREFERABLY 260 TO 340, MORE PREFERABLY 290 TO 310 AND MOST PREFERABLY 300, A PH OF 7.0 AND 8.8 ND MORE PREFERABLY BETWEEN 7.5 AND 8.5, AND MOST PREFERABLY 8.1 AND FORMED OF COMPOUNDS HAVING AN ACTIVITY COEFFICIENT IN THE SOLUTION OF AT LEAST 0.8 AT 37*C TO PROVIDE CONCENTRATION IN MILLIOSMOLS/LITER OF NA* 75-200, PREFERABLY 85-150, MORE PREFERABLY 127-135 AND MOST PREFERABLY 131, OF K* 7-25, PREFERABLY 10-20, MORE PREFERABLY 131, OF K* 7-25, 14, OF MG** 3-8 AND PREFERABLY 5, OF HPO4= OR SO4= OR ACETATE OR GLUCONATE 3-8 AND PREFERABLY 5, OR HCO3 12-28, PREFERABLY 10-30, MORE PREFERABLY 16-20 AND MOST PREFERABLY 18 AND OF CI-70-195, PREFERABLY 85-185. MORE PFEFERABLY 124-130 AND MOST PREFERABLY 127.

Claim 7

A method for administration of solutes to a mammal wherein the solutes are mixed in an aqueous solution, characterized by the aqueous solution having an osmolality in milliosmols/liter of 170 to 460, preferably 260 to 340, more preferably 290 to 310 and most preferably 300, and formed of compounds having an activity coefficient in the solution of at least 0.8 at 37*C to provide concentration in milliosmols/liter of Na 75-200, preferably 85-150, more preferably 127-135 and most preferably 131, of K 7-25, preferably 10-20, more preferably 13-15 and most preferably 14, of Mg 3-8 and preferably 5, of HP04 or S04 or acetate or gluconate 3-8 and preferably 5, of HC03 12-28, preferably 10-30, more preferably 16-20 and most preferably 18 and of C1 70-195, preferablY 85-185, more preferably 124-130 and most preferably 127, and a pH insufficiently different from that of the fluid system of the mammal to which it is to be administered to materially alter the system pH.

Claim 8

A method for administration of solutes to a mammal wherein the solutes are mixed in an aqueous solution, characterized by the aqueous solution having an osmolality in milliosmols/liter of 170 to 460, preferably 260 to 340, more preferably 290 to 310 and most preferably 300, and formed of compounds having an activity coefficient in the solution of at least 0.8 at 37*C to provide concentration in milliosmols/liter of Na 75-200, preferably 85-150, more preferably 127-135 and most preferably 131, of K 7-25, preferably 10-20, more preferably 13-15 and most preferably 14, of Mg 3-8 and preferably 5, of HP04 or S04 or acetate or gluconate 3-8 and preferably 5, of HC03 12-28, preferably 10-30, more preferably 16-20 and most preferably 18 and of C1 70-195, preferablY 85-185, more preferably 124-130 and most preferably 127, and a pH insufficiently different from that of the fluid system of the mammal to which it is to be administered to materially alter the system pH.