US3896153A
Expired / Lapsed
US
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Synthesis of quinone derivatives having biological activity
Assignee: Eisai Co Ltd
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Filing: 1974-03-25
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Granted: 1975-07-22
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Expires: 1994-03-25
Abstract
Abstract New method for the synthesis of benzo- and naphthoquinone derivatives involving coenzyme Q and vitamins K1 and K2 is provided which comprises reacting a pi -allyl-type halonickel complex compound with 2,3-dimethoxy-5-methyl-6-halo-benzoquinone or 2-methyl-3-halo-1,4-naphthoquinone in an organic solvent. Beneficial advantage of the method relies upon its simplicity of the reaction step with high yield of the desired products.
Inventors
- 👤 Kikumasa Sato
- 👤 Seiichi Inoue
- 👤 Shizumasa Kijima
- 👤 Kimio Hamamura
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 01:43
CPC Classifications
C; C07; C07C; C07C50/00; C07C50/10; C07C50/14; C07C46/00; C07C50/26; C07C50/28
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
15 words
A PROCESS FOR THE SYNTHESIS OF QUINONE DERIVATIVES HAVING BIOLOGICAL ACTIVITY REPRESENTED BY THE FORMULA:
Claim 2
Dependent Claim
15 words
A PROCESS FOR THE SYNTHESIS OF QUINONE DERIVATIVES HAVING BIOLOGICAL ACTIVITY REPRESENTED BY THE FORMULA:
Claim 3
Dependent Claim
19 words
A process as claimed in claim 1 wherein vitamin K1 is produced by reacting phytyl bromonickel complex with 2-methyl-3-bromo-naphthoquinone.
Claim 4
Dependent Claim
19 words
A process as claimed in claim 1 wherein vitamin K2(5) is produced by reacting prenyl bromonickel complex with 2-methyl-3-bromo-naphthoquinone.
Claim 5
Dependent Claim
19 words
A process as claimed in claim 1 wherein vitamin K2(20) is produced by reacting geranylgeranyl bromonickel complex with 2-methyl-3-bromo-naphthoquinone.
Claim 6
Dependent Claim
19 words
A process as claimed in claim 1 wherein coenzyme Q(9) is produced by reacting solanesyl bromonickel complex with 2,3-dimethoxy-5-methyl-6-bromo-benzoquinone.
Claim 7
Dependent Claim
19 words
A process as claimed in claim 1 wherein coenzyme Q(10) is produced by reacting decaprenyl bromonickel complex with 2,3-dimethoxy-5-methyl-6-bromobenzoquinone.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-07-21 | 1979-01-20 | 1979-07-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-07-21 | 1983-01-20 | 1983-07-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-07-21 | 1987-01-20 | 1987-07-22 | $7700.00 | Window Closed / Lapsed |