US3896119A
Expired / Lapsed
US
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Xanthines substituted in the 8-position
Assignee: Evonik Operations GmbH
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Filing: 1972-09-27
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Granted: 1975-07-22
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Expires: 1992-09-27
Abstract
Abstract Compound are prepared having the formula: where R1 is hydrogen or methyl, R2 and R3 are hydrogen, methyl, hydroxy, or hydroxymethyl, R7 is hydrogen or methyl and R4 is alkyl of 1 to 6 carbon atoms, phenylalkyl of 7 to 12 carbon atoms or -NR5R6 where R5 and R6 individually are hydrogen or alkyl of 1 to 6 carbon atoms or R5 and R6 together with the nitrogen atom form a 5 to 7 membered ring which can have an additional oxygen, nitrogen or sulfur atom and also can contain 0 to 2 alkyl substituents with 1 to 4 carbon atoms or salts thereof. The compounds have outstanding broncholytic activity.
Inventors
- 👤 Karl-Heinz Klingler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 16:18
CPC Classifications
C; C07; C07D; C07D473/00; C07D473/02; C07D473/04; C07D473/06; C07D473/08
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
5 words
A COMPOUND HAVING THE FORMULA:
Claim 2
Dependent Claim
5 words
A COMPOUND HAVING THE FORMULA:
Claim 3
Dependent Claim
20 words
A compOund according to claim 1 wherein R5 and R6 are hydrogen or alkyl of 1 to 6 carbon atoms.
Claim 4
Dependent Claim
10 words
A compound according to claim 2 wherein R3 is hydroxyl.
Claim 5
Dependent Claim
19 words
A compound according to claim 2 wherein both R5 and R6 are alkyl of 1 to 6 carbon atoms.
Claim 6
Dependent Claim
10 words
A compound according to claim 4 wherein R3 is hydroxyl.
Claim 7
Dependent Claim
13 words
A compound according to claim 4 wherein both R5 and R6 are ethyl.
Claim 8
Dependent Claim
10 words
A compound according to claim 6 wherein R3 is hydroxyyl.
Claim 9
Dependent Claim
24 words
A compound according to claim 1 wherein when R5 and R6 are taken collectively with the nitrogen atom the heteroCyclic ring has the formula
Claim 10
Dependent Claim
34 words
A compound according to claim 8 wherein R2 is hydrogen, methyl or hydroxyl, R3 is hydroxyl, and R4 is dialkylamino wherein the alkyl group has 1 to 6 carbon atoms, morpholino, methylmorpholino or piperidino.
Claim 11
Dependent Claim
19 words
A compound according to claim 9 wherein R2, R3, and R7 are in the 3, 4 and 5 positions.
Claim 12
Dependent Claim
35 words
A compound according to claim 8 wherein R2 is hydrogen, methyl, hydroxy or hydroxymethyl, R3 is hydroxy and R2, R3 and R7 are in the 3,4 and 5 positions, and R4 is morpholino or methylmorpholino.
Claim 13
Dependent Claim
30 words
A compound according to claim 8 wherein R1 is hydrogen, R2 and R3 are hydroxyl groups in the 3,4 or 3,5 position and R4 is a ring of the formula:
Claim 14
Dependent Claim
10 words
A compound according to claim 8 wherein R7 is methyl.
Claim 15
Dependent Claim
10 words
A compound according to claim 8 wherein R7 is hydrogen.
Claim 16
Dependent Claim
23 words
A compound according to claim 14 wherein R2 is hydrogen, methyl or hydroxyl, R3 is hydroxyl, R4 is diethylamino, morpholino, or methyl morpholino.
Claim 17
Dependent Claim
8 words
A compound according to claim 1 wherein R4
Claim 18
Dependent Claim
14 words
A compound according to claim 16, wherein X is oxygen and n is 2.
Claim 19
Dependent Claim
7 words
A compound according to claim 17 wherein
Claim 20
Dependent Claim
7 words
A compound according to claim 18 wherein
Claim 21
Dependent Claim
17 words
A compound according to claim 19 wherein R2 is hydrogen, methyl or hydroxyl and R3 is hydroxyl.
Claim 22
Dependent Claim
19 words
A compound according to claim 20 wherein R2, R3 and R7 are in the 3, 4 and 5 positions.
Claim 23
Dependent Claim
10 words
A compound according to claim 18, wherein R7 is methyl.
Claim 24
Dependent Claim
10 words
A compound according to claim 18, wherein R7 is hydrogen.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-07-21 | 1979-01-20 | 1979-07-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-07-21 | 1983-01-20 | 1983-07-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-07-21 | 1987-01-20 | 1987-07-22 | $7700.00 | Window Closed / Lapsed |