US3895103A
Expired / Lapsed
US
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Intrauterine contraceptive device containing certain pharmaceutically acceptable steroids
Assignee: Alza Corp
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Filing: 1973-10-16
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Granted: 1975-07-15
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Expires: 1993-10-16
Abstract
Abstract An intrauterine delivery device for the administration of antifertility steroid to a uterine cavity comprising a body of nontoxic, biologically inert, polymeric release rate controlling material containing therein a locally contraceptively active steroid metabolite of progesterone and permeable to the passage of the steroid as by diffusion; and wherein the device, while in the uterus, continuously meters the flow of a contraceptively effective amount of the steroid metabolite through the material at a controlled and predetermined rate by diffusion over a period of time to produce the anti-fertility effect.
Inventors
- 👤 Alejandro Zaffaroni
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:23
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0034; A61K9/0039; A61F; A61F6/00; A61F6/06; A61F6/14; A61M; A61M31/00; A61M31/002; C; C07; C07J; C07J7/00; C07J7/0005; C07J7/001; C07J7/0065
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
99 words
AN INTRAUTERINE DEVICE ADAPTED FOR INSERTION AND PLACEMENT IN A UTERUS FOR THE RELEASE OF A PHARMACEUTICALLY ACCEPTABLE ANTI-FERTILITY STEROID METABOLITE COMPRISING, A MATRIX FROMED OF A NONTOXIC, BIOLOGICALLY INERT POLYMERIC RELEASE RATE CONTROLLING METERIAL CONTAINING A LOCALLY, CONTRACEPTIVELY ACTIVE SATURATED METABOLITE OF PROGESTERONE AND PERMEABLE TO THE PASSAGE OF THE METABOLITE BY DIFFUSION, AND WHEREIN THE INTRAUTERINE DEVICE WHEN PLACED IN THE UTERUS METERS THE FLOW OF AN EFFECTIVE AMOUNT OF THE METABOLITE UP TO 1500 MICROGRAMS PER DAY FOR AN ANTIFERTILITY EFFECT THROUGH THE MATERIAL AT A CONTROLLED AND CONTINUOUS RATE OVER A PROLONGED PERIOD OF TIME.
Claim 2
Dependent Claim
99 words
AN INTRAUTERINE DEVICE ADAPTED FOR INSERTION AND PLACEMENT IN A UTERUS FOR THE RELEASE OF A PHARMACEUTICALLY ACCEPTABLE ANTI-FERTILITY STEROID METABOLITE COMPRISING, A MATRIX FROMED OF A NONTOXIC, BIOLOGICALLY INERT POLYMERIC RELEASE RATE CONTROLLING METERIAL CONTAINING A LOCALLY, CONTRACEPTIVELY ACTIVE SATURATED METABOLITE OF PROGESTERONE AND PERMEABLE TO THE PASSAGE OF THE METABOLITE BY DIFFUSION, AND WHEREIN THE INTRAUTERINE DEVICE WHEN PLACED IN THE UTERUS METERS THE FLOW OF AN EFFECTIVE AMOUNT OF THE METABOLITE UP TO 1500 MICROGRAMS PER DAY FOR AN ANTIFERTILITY EFFECT THROUGH THE MATERIAL AT A CONTROLLED AND CONTINUOUS RATE OVER A PROLONGED PERIOD OF TIME.
Claim 3
Dependent Claim
111 words
The intrauterine device of claim 1 wherein the device is adapted to release about 5 micrograms to about 50 micrograms of the locally, contraceptively active steroid metabolite per kilogram of body weight per day and wherein said metabolite is a member selected from the group: 5 Beta -pregnane-3 Alpha -hydroxy-20-one, 5 Alpha -pregnane-3 Beta ,16 Alpha -dihydroxy-20-one, 5 Alpha -pregnane-3 Alpha ,16 Alpha -dihydroxy-20-one, 5 Beta -pregnane-3 Alpha ,20 Beta -diOl, 5 Alpha -pregnane-3,20-dione, 5 Beta -pregnane-3,20-dione, 5 Alpha -pregnane-3 Alpha -hydroxy-20-one, 5 Alpha -pregnane-3 Alpha ,20 Alpha -diol, 5 Alpha -pregnane-3 Alpha ,20 Beta -diol, 5 Beta -pregnane-3 Alpha ,17 Alpha -dihydroxy-20-one, and mixtures thereof, essentially without systemic progestational effects.
Claim 4
Dependent Claim
116 words
An intrauterine device for the administration of a physiologically compatible steorid for interfering with the reproductive process to the uterine cavity comprising a matrix formed of nontoxic, biologically inert polymeric release rate controlling material containing therein 250 nanograms to 5 grams of a locally contraceptively active steroid metabolite of progesterone and permeable to the passage of the steroid by diffusion, and wherein the device when placed in the cavity meters the flow of an effective amount of the steroid up to 1500 micrograms per day for an antifertility effect through the material at a controlled and continuous rate over a prolonged period of time with the steroid consisting of a member selected from the group of:
Claim 5
Dependent Claim
116 words
An intrauterine device for the administration of a physiologically compatible steorid for interfering with the reproductive process to the uterine cavity comprising a matrix formed of nontoxic, biologically inert polymeric release rate controlling material containing therein 250 nanograms to 5 grams of a locally contraceptively active steroid metabolite of progesterone and permeable to the passage of the steroid by diffusion, and wherein the device when placed in the cavity meters the flow of an effective amount of the steroid up to 1500 micrograms per day for an antifertility effect through the material at a controlled and continuous rate over a prolonged period of time with the steroid consisting of a member selected from the group of:
Claim 6
Dependent Claim
23 words
The intrauterine device of claim 3 when the steroid is 5 Alpha , the groups R1, R2, W, and X are as follows:
Claim 7
Dependent Claim
107 words
An intrauterine device adapted for insertion and placement in a uterine cavity for the adminstration of a pharmaceutical antifertility steorid metabolite to the cavity comprising a reservoir surrounded by a wall formed of a nontoxic, biologically inert polymeric release rAte controlling material containing therein a locally, contraceptively active saturated steroid metabolite of progesterone and permeable to the passage of the steroid by diffusion, and wherein the device when placed in the cavity meteres the flow of an effective amount of the steroid up to 1500 micrograms per day for an antifertility effect through the material at a controlled and continuous rate over a prolonged period of time.
Claim 8
Dependent Claim
107 words
An intrauterine device adapted for insertion and placement in a uterine cavity for the adminstration of a pharmaceutical antifertility steorid metabolite to the cavity comprising a reservoir surrounded by a wall formed of a nontoxic, biologically inert polymeric release rAte controlling material containing therein a locally, contraceptively active saturated steroid metabolite of progesterone and permeable to the passage of the steroid by diffusion, and wherein the device when placed in the cavity meteres the flow of an effective amount of the steroid up to 1500 micrograms per day for an antifertility effect through the material at a controlled and continuous rate over a prolonged period of time.
Claim 9
Dependent Claim
111 words
The intrauterine device of claim 5 wherein the device is adapted to release about 5 micrograms to about 50 micrograms of the locally, contraceptively active steroid metabolite per kilogram of body weight per day and wherein said steorid is a member selected from the group: 5 Beta -pregnane-3 Alpha -hydroxy-20-one, 5 Alpha -pregnane-3 Beta ,16 Alpha -dihydroxy-20-one, 5 Alpha -pregnane-3 Alpha ,16 Alpha -dihydroxy-20-one, 5 Beta -pregnane-3 Alpha ,20 Beta -diol, 5 Alpha -pregnane-3,20-dione, 5 Beta -pregnane-3,20-dione, 5 Alpha -pregnane-3 Alpha -hydroxy-20-one, 5 Alpha -pregnane-3 Alpha ,20 Alpha -diol, 5 Alpha -pregnane-3 Alpha ,20 Beta -diol, 5 Beta -pregnane-3 Alpha ,17 Alpha -dihydroxy-20-one, and mixtures thereof, essentially without systemic progestational effects.
Claim 10
Dependent Claim
119 words
An intrauterine device for the administration of a physiologically compatible steroid for interfering with the reproductive process to a uterine cavity comprising a reservoir surrounded by a wall formed of nontoxic, biologically inert polymeric release rate controlling material containing 250 nanograms to 5 grams of a locally contraceptively active steroid metabolite of progesterone and permeable to the passage of the steroid by diffusion, and wherein the device when placed in the uterus meters the flow of an effective amount of the steroid up to 1500 micrograms per day for an antifertility effect through the material at a controlled and continuous rate over a prolonged period of time with the steroid consisting of a member selected from the group of:
Claim 11
Dependent Claim
119 words
An intrauterine device for the administration of a physiologically compatible steroid for interfering with the reproductive process to a uterine cavity comprising a reservoir surrounded by a wall formed of nontoxic, biologically inert polymeric release rate controlling material containing 250 nanograms to 5 grams of a locally contraceptively active steroid metabolite of progesterone and permeable to the passage of the steroid by diffusion, and wherein the device when placed in the uterus meters the flow of an effective amount of the steroid up to 1500 micrograms per day for an antifertility effect through the material at a controlled and continuous rate over a prolonged period of time with the steroid consisting of a member selected from the group of:
Claim 12
Dependent Claim
24 words
The intrauterine delivery device of claim 7 when the steroid is 5 Alpha , the groups R1, R2, W, and X are as follows:
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-07-14 | 1979-01-13 | 1979-07-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-07-14 | 1983-01-13 | 1983-07-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-07-14 | 1987-01-13 | 1987-07-15 | $7700.00 | Window Closed / Lapsed |