Products and process

Abstract

Abstract Compounds of the formula: WHEREIN T is a radical selected from the group consisting of CH CH- and -CH2CH2-; Z is >C O, >CH2, or >CHOR; R is hydrogen, alkyl, aromatic hydrocarbon radicals or acyl; X is hydrogen, -OR or -OR''; R'' is benzoxazolyl, benzothiazolyl, or phenyltetrazolyl, X'' is X or tetrahydropyranyloxy; Y is hydrogen, or hydroxyl; and unless at least one of X and X'' is tetrahydropyranyloxy, benzoxazolyloxy, benzothiazolyloxy, or phenyltetrazolyloxy, then at least one of X and X'' is hydrogen; and animal feeds containing growth promoting amounts of these compounds. The novel compounds can be prepared from zearalenone and appropriate derivatives or zearalenone by (a) etherifying at least one or both of the substituents in the 2 and 4 positions (the X substituents) of the A ring with certain heterocyclic compounds and subjecting the ether to hydrogenolysis to cleave the heterocyclic ether radical and replace at least one of these substituents with hydrogen and (b) when producing compounds having at least one hydroxyl, amino or nitro substituent in the 3 and 5 positions (the Y substituents) of the A ring, nitrating either one or both, depending upon the final compound desired, of the 3 and 5 positions of compounds produced by process (a) and converting, when desired, the nitro substituent to an amino or a hydroxyl substituent. Alternatively, compounds having at least one of a hydroxyl, amino or nitro substituent can be used as a starting material in process (a).

Inventors

• 👤 Herbert L Wehrmeister
• 👤 David B R Johnston
• 👤 Thomas B Windholz

Bibliographic Details