US3884905A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pro-drug forms of digoxin
Assignee: Interx Research Corp
•
Filing: 1974-05-02
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Granted: 1975-05-20
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Expires: 1994-05-02
Abstract
Abstract There is provided, a novel pro-drug form of digoxin having the following formula: WHEREIN R represents a member selected from among a hydrogen atom, a picolinoyl group, a nicotinoyl group, and an isonicotinoyl group, with the proviso that at least one of said R must represent a picolinoyl group, a nicotinoyl group, or an isonicotinoyl group. These novel compounds will be cleaved in the bloodstream, delivering digoxin. Due to their higher solubility and better absorption characteristics, they permit, a higher and more reproducible level of digoxin bio-availability to be attained than that which could be attained if digoxin per se was administered.
Inventors
- 👤 Nicolae S Bodor
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 07:40
CPC Classifications
C; C07; C07J; C07J19/00; C07J19/005; C07J43/00; C07J43/003
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
6 words
A DIGOXIN COMPOUND OF THE FORMULA:
Claim 2
Dependent Claim
6 words
A DIGOXIN COMPOUND OF THE FORMULA:
Claim 3
Dependent Claim
9 words
The compound of claim 1, wherein R represents nicotinoyl.
Claim 4
Dependent Claim
9 words
The compound of claim 1, wherein R represents picolinoyl.
Claim 5
Dependent Claim
9 words
The compound of claim 1, wherein R represents iso-nicotinoyl.
Claim 6
Dependent Claim
7 words
The compound of claim 1: Digoxin Pentanicotinate.
Claim 7
Dependent Claim
7 words
The compound of claim 1: Digoxin Penta-iso-nicotinate.
Claim 8
Dependent Claim
7 words
The compound of claim 1: Digoxin Pentapicolinate.
References Cited (Backward Citations)
US3696091A
Cited
US3804825A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-05-19 | 1978-11-18 | 1979-05-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-05-19 | 1982-11-18 | 1983-05-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-05-19 | 1986-11-18 | 1987-05-20 | $7700.00 | Window Closed / Lapsed |