US3883656A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical preparations for the treatment of hypertonia
Assignee: Novartis Corp
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Filing: 1972-10-30
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Granted: 1975-05-13
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Expires: 1992-10-30
Abstract
Abstract Pharmaceutical preparations containing a combination of the antihypertensively active amino acid and of a Beta -hydroxylase inhibitor for the treatment of hypertonia. Said preparations prolong the antihypertensive action substantially greater than that would be achieved by administration of individual compounds.
Inventors
- 👤 Phyllis Roberta Hedwall
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 19:58
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
61 words
A PHARMACEUTICAL PREPARATION FOR TREATING HYERTONIA WHICH CONTAINS AN EFFECTIVE AMOUNT OF AN EFFECTIVE AMOUNT OF AN A AMINO ACID COMPOUND SELECTED FROM THE GROUP CONSISTING OF AN A-AMINO-A-METHYL-B-(HYDROXYLATED HENYL)-PROPIONIC ACID, A NON-TOXIC SALT THEREOF AND A LOWER ALKYL ESTER THEREOF, AND AN EFFECTIVE AMOUNT OF A B-HYDROXYLASE INHIBITOR COMPOUND SELECTED FROM THE GROUP CONSISTING OF A COMPOUND OF THE FORMULA
Claim 2
Dependent Claim
61 words
A PHARMACEUTICAL PREPARATION FOR TREATING HYERTONIA WHICH CONTAINS AN EFFECTIVE AMOUNT OF AN EFFECTIVE AMOUNT OF AN A AMINO ACID COMPOUND SELECTED FROM THE GROUP CONSISTING OF AN A-AMINO-A-METHYL-B-(HYDROXYLATED HENYL)-PROPIONIC ACID, A NON-TOXIC SALT THEREOF AND A LOWER ALKYL ESTER THEREOF, AND AN EFFECTIVE AMOUNT OF A B-HYDROXYLASE INHIBITOR COMPOUND SELECTED FROM THE GROUP CONSISTING OF A COMPOUND OF THE FORMULA
Claim 3
Dependent Claim
60 words
The pharmaceutical preparation of claim 1, containing an effective amount of a compound selected from the group consisting of Alpha -amino Alpha -methyl- Beta -(4-hydroxyphenyl)-propionic acid, Alpha -amino- Alpha -methyl- Beta -(3,4-dihydroxyphenyl)-propionic acid and nontoxic salts thereof and an effective amount of a Beta -hydroxylase inhibitor selected from the group consisting of a compound of fusaric acid, bis-(diethylthiocarbamoyl)-disulphide and bis-((3-aza-3-methyl-hexylene-1,6)-thiocarbamoyl)-disulphide.
Claim 4
Dependent Claim
71 words
The pharmaceutical preparation of claim 1, which contains an effective amount of a compound selected from the group consisting of Alpha -amino- Alpha -methyl- Beta -(4-hydroxyphenyl)-propionic acid, Alpha -amino- Alpha -methyl- Beta -(3,4-dihydroxyphenyl)-propionic acid, its alkali metal salt and an alkaline earth metal salt thereof and an effective amount of a compound selected from the group consisting of 5-n-pentyl-picolinic acid, 5-n-butyl-picolinic acid, methyl and ethyl esters thereof and non-toxic salt thereof.
Claim 5
Dependent Claim
64 words
The pharmaceutical preparation of claim 1, which contains an effective amount of a compound selected from the group consisting of Alpha -amino- Alpha -methyl- Beta -(3,4-dihydroxyphenyl)-propionic acid, non-toxic alkali metal salts thereof and non-toxic alkaline earth metal salts thereof and an effective amount of the compound selected from the group consisting of 5-n-butyl-picolinic acid, its methyl or ethyl ester, and a non-toxic salt thereof.
Claim 6
Dependent Claim
28 words
The pharmaceutical preparation of claim 1, which contains Alpha -amino- Alpha -methyl- Beta -(3,4-dihydroxyphenyl)-propionic acid or a non-toxic salt thereof and 5-n-butyl-picolinic acid or a nontoxic salt thereof.
Claim 7
Dependent Claim
25 words
The pharmaceutical preparation of claim 1, which contains effective amounts of Alpha -amino- Alpha -methyl- Beta -(3,4-dihydroxyphenyl)-propionic acid or a non-toxic salt thereof, and bis-(diethylthiocarbamoyl)-disulphide.
Claim 8
Dependent Claim
25 words
The pharmaceutical preparation of claim 1, which contains effective amounts of Alpha -amino- Alpha -methyl- Beta -(3,4-dihydroxyphenyl)-propionic acid or a non-toxic salt thereof, and bis-((3-aza-3-methyl-hexylene-1,6)-thiocarbamoyl)-disulphide.
Claim 9
Dependent Claim
27 words
The pharmaceutical preparation of claim 1, containing 100-200 mg of Alpha -amino- Alpha -methyl- Beta -(3,4-dihydroxyphenyl)-propionic acid and 50-200 mg of the calcium salt of 5-n-butylpicolinic acid.
Claim 10
Dependent Claim
27 words
The pharmaceutical preparation of claim 1, containing 150-200 mg of Alpha -amino- Alpha -methyl- Beta -(3,4-dihydroxyphenyl)-propionic acid and 100-200 mg of the calcium salt of 5-n-butylpicolinic acid.
Claim 11
Dependent Claim
21 words
Process for the treatment of hypertonia, characterized in that a pharmaceutical preparation of claim 1 is administered to a warm-blooded organism.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-05-12 | 1978-11-11 | 1979-05-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-05-12 | 1982-11-11 | 1983-05-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-05-12 | 1986-11-11 | 1987-05-13 | $7700.00 | Window Closed / Lapsed |