US3879535A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anesthetic compositions and methods of use
Assignee: Parke Davis and Co LLC
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Filing: 1974-01-17
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Granted: 1975-04-22
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Expires: 1994-01-17
Abstract
Abstract Pharmaceutical compositions for anesthetic use comprising one part by weight of 2-(ethylamino)-2-(2-thienyl)cyclohexanone in combination with 0.1 to 10 parts by weight of 4-(o-fluorophenyl)6,8-dihydro-1,3,8-trimethyl-pyrazolo(3,4-e)(1,4)diazepin -7(1H)one. Methods for the induction of anesthesia in mammals by parenterally administering 2-(ethylamino)-2-(2thienyl)cyclohexanone in combination with 4-(o-fluorophenyl)-6,8dihydro-1,3,8-trimethylpyrazolo(3,4-e)(1,4)diazepin -7(1H)-one in the proportions indicated above. In the compositions and methods of the invention the substances can be used in either free base or acid-addition salt form.
Inventors
- 👤 Harry E Stoliker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 20:49
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/02; C07D487/04; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/55
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
30 words
A pharmaceutical composition possessing anesthetic activity and suitable for parenteral administration, comprising, in combination, one part by weight of 2-(ethylamino)-2-(2-thienyl)cyclohexanone and 0.33 to 3 parts by weight of 4-(o-fluorophenyl)-6,8-dihydro-1,3,8-trimethylpyrazolo(3,4-e)(1, 4)diazepin-7(1H)-one.
Claim 2
Dependent Claim
30 words
A pharmaceutical composition possessing anesthetic activity and suitable for parenteral administration, comprising, in combination, one part by weight of 2-(ethylamino)-2-(2-thienyl)cyclohexanone and 0.33 to 3 parts by weight of 4-(o-fluorophenyl)-6,8-dihydro-1,3,8-trimethylpyrazolo(3,4-e)(1, 4)diazepin-7(1H)-one.
Claim 3
Dependent Claim
30 words
A PHARMACEUTICAL COMPOSITION POSSESSING ANESTHETIC ACTIVITY AND SUITABLE FOR PARENTERAL ADMINISTRATION, COMPRISING, IN COMBINATION, ONE PART BY WEIGHT OF 2-(ETHYLAMINO)-2(2-THIENYL)CYCLOHEXANONE AND 0.33 TO 3 PARTS BY WEIGHT OF 4-(O-FLUOROPHENYL)-6-8-DIHYDRO- 1,3,8-TRIMETHYLPYRAZOLO(3,4E$1,4)DIAZEPIN-7(1H)-ONE.
Claim 4
Dependent Claim
30 words
A PHARMACEUTICAL COMPOSITION POSSESSING ANESTHETIC ACTIVITY AND SUITABLE FOR PARENTERAL ADMINISTRATION, COMPRISING, IN COMBINATION, ONE PART BY WEIGHT OF 2-(ETHYLAMINO)-2(2-THIENYL)CYCLOHEXANONE AND 0.33 TO 3 PARTS BY WEIGHT OF 4-(O-FLUOROPHENYL)-6-8-DIHYDRO- 1,3,8-TRIMETHYLPYRAZOLO(3,4E$1,4)DIAZEPIN-7(1H)-ONE.
Claim 5
Dependent Claim
21 words
The pharmaceutical composition of claim 1 wherein the 2-(ethylamino)-2-(2-thienyl)cyclohexanone and the 4-(o-fluorophenyl)-6,8-dihydro-1,3,8-trimethylpyrazolo(3,4-e)(1, 4)diazepin-7(1H)-one, are present in the form of acid-addition salts.
Claim 6
Dependent Claim
13 words
The pharmaceutical composition of claim 2 wherein the acid-addition salts are the hydrochlorides.
Claim 7
Dependent Claim
27 words
The pharmaceutical composition of claim 2 in the form of an aqueous solution for parenteral administration containing at least 2.5 mg. of 2-(ethylamino)-2-(2-thienyl)cyclohexanone per ml. of solution.
Claim 8
Dependent Claim
37 words
The pharmaceutical composition of claim 2 in the form of a freeze-dried formulation suitable for reconstitution with water to give an aqueous solution for parenteral administration containing at least 2.5 mg. of 2-(ethylamino)-2-(2-thienyl)cyclohexanone per ml. of solution.
Claim 9
Independent Claim
36 words
A method for inducing anesthesia in mammals which comprises administering by a parenteral route, in combination, an anesthetically-effective quantity of one part by weight of 2-(ethylamino)-2-(2-thienyl)cyclohexanone and 0.33 to 3 parts by weight of 4-(o-fluorophenyl)-6,8-dihydro-1,3,8-trimethylpyrazolo(3,4-e) (1,4)diazepin-7(1H)-one.
Claim 10
Independent Claim
36 words
A method for inducing anesthesia in mammals which comprises administering by a parenteral route, in combination, an anesthetically-effective quantity of one part by weight of 2-(ethylamino)-2-(2-thienyl)cyclohexanone and 0.33 to 3 parts by weight of 4-(o-fluorophenyl)-6,8-dihydro-1,3,8-trimethylpyrazolo(3,4-e) (1,4)diazepin-7(1H)-one.
Claim 11
Dependent Claim
20 words
The method of claim 6 wherein the 2-(ethylamino)-2-(2-thienyl)cyclohexanone and the 4-(o-fluorophenyl)-6,8-dihydro-1,3, 8-trimethylpyrazolo(3,4-e)(1,4)diazepin-7(1H)-one are present in the form of acid-addition salts.
Claim 12
Dependent Claim
12 words
The method of claim 7 wherein the acid-addition salts are the hydrochlorides.
Claim 13
Dependent Claim
13 words
The method of claim 6 wherein the parenteral route is the intravenous route.
References Cited (Backward Citations)
US3522273A
Cited
US3558605A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-04-21 | 1978-10-21 | 1979-04-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-04-21 | 1982-10-21 | 1983-04-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-04-21 | 1986-10-21 | 1987-04-22 | $7700.00 | Window Closed / Lapsed |