US3879511A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Tasteless methenamine mandelate in a stabilized vegetable oil suspension
Assignee: Warner Lambert Co LLC
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Filing: 1973-08-27
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Granted: 1975-04-22
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Expires: 1993-08-27
Abstract
Abstract A substantially tasteless methenamine mandelate suspension contains particles of methenamine mandelate enveloped in a coating of ethyl cellulose and at least one secondary coating ingredient including hydrogenated castor oil, paraffin, and/or a polyethylene glycol polymer or mixture of polyethylene glycol polymers. The coating is applied from a solvent solution, using conventional spray drying techniques. The coated methenamine mandelate particles are suspended in a vegetable oil vehicle to which a suspension stabilizer may be added. This suspension is stable, palatable and therapeutically active, upon oral administration, for the treatment of urinary infections. The addition of artificial sweeteners to mask the normally unpleasant taste of methenamine mandelate is not required. Flavor, coloring and relatively small amounts of sugar may be added to the suspension to provide specific taste qualities, if desired.
Inventors
- 👤 Frank W Goodhart
- 👤 James R Draper
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 04:16
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0087; A61K9/0095; A61K31/00; A61K31/33; A61K31/395; A61K31/53; A61K9/48; A61K9/50; A61K9/5005; A61K9/5015; A61K9/5021; A61K9/5031; A61K9/5036; A61K9/5042; A61K9/5047
Claims Analysis
Total Claims: 31
Claim 1
Independent Claim
62 words
A SUBSTANTIALLY TASTELESS SUSPENSION OF COATED METHENAMINE MANDELATE PARTICLES CONSISTING ESSENTIALLY OF: A. FROM ABOUT 49% TO ABOUT 91.25% BY WEIGHT, BASED ON THE TOTAL WEIGHT OF THE SUSPENSION OF VEGETABLE OIL VEHICLE; B. FROM ABOUT 0 TO ABOUT 2.5% BY WEIGHT OF A SUSPENSION STABILIZER; AND C. FROM ABOUT 6.25% TO ABOUT 51% BY WEIGHT OF COATED METHENAMINE MANDELATE PARTICLES COMPRISING;
Claim 2
Dependent Claim
62 words
A SUBSTANTIALLY TASTELESS SUSPENSION OF COATED METHENAMINE MANDELATE PARTICLES CONSISTING ESSENTIALLY OF: A. FROM ABOUT 49% TO ABOUT 91.25% BY WEIGHT, BASED ON THE TOTAL WEIGHT OF THE SUSPENSION OF VEGETABLE OIL VEHICLE; B. FROM ABOUT 0 TO ABOUT 2.5% BY WEIGHT OF A SUSPENSION STABILIZER; AND C. FROM ABOUT 6.25% TO ABOUT 51% BY WEIGHT OF COATED METHENAMINE MANDELATE PARTICLES COMPRISING;
Claim 3
Dependent Claim
22 words
FROM ABOUT 20 TO ABOUT 80% BY WEIGHT OF FINELY POWDERED METHENAMINE MANDELATE, BASED ON THE TOTAL WEIGHT OF THE COATED PARTICLES;
Claim 4
Dependent Claim
22 words
FROM ABOUT 20 TO ABOUT 80% BY WEIGHT OF FINELY POWDERED METHENAMINE MANDELATE, BASED ON THE TOTAL WEIGHT OF THE COATED PARTICLES;
Claim 5
Dependent Claim
62 words
A substantially tasteless suspension of coated methenamine mandelate particles consisting essentially of: A. from about 49% to about 91.25% by weight, based on the total weight of the suspension, of vegetable oil vehicle; B. from about 0 to about 2.5% by weight of a suspension stabilizer; and C. from about 6.25% to about 51% by weight of coated methenamine mandelate particles comprising;
Claim 6
Dependent Claim
62 words
A substantially tasteless suspension of coated methenamine mandelate particles consisting essentially of: A. from about 49% to about 91.25% by weight, based on the total weight of the suspension, of vegetable oil vehicle; B. from about 0 to about 2.5% by weight of a suspension stabilizer; and C. from about 6.25% to about 51% by weight of coated methenamine mandelate particles comprising;
Claim 7
Dependent Claim
22 words
from about 20 to about 80% by weight of finely powdered methenamine mandelate, based on the total weight of the coated particles;
Claim 8
Dependent Claim
22 words
from about 20 to about 80% by weight of finely powdered methenamine mandelate, based on the total weight of the coated particles;
Claim 9
Dependent Claim
7 words
about 44.5% of finely powdered methenamine mandelate;
Claim 10
Dependent Claim
7 words
about 44.5% of finely powdered methenamine mandelate;
Claim 11
Dependent Claim
22 words
from about 44 to about 65% by weight of finely powdered methenamine mandelate, based on the total weight of the coated particles;
Claim 12
Dependent Claim
22 words
from about 44 to about 65% by weight of finely powdered methenamine mandelate, based on the total weight of the coated particles;
Claim 13
Dependent Claim
61 words
A substantially tasteless suspension according to Claim 1 consisting essentially of: A. from about 74.77 to about 89.81% by weight, based on the total weight of the suspension, of vegetable oil vehicle; B. from about 0.1 to about 2.5% by weight of a suspension stabilizer; and C. from about 7.69 to about 22.73% by weight of coated methenamine mandelate particles comprising:
Claim 14
Dependent Claim
17 words
about 22.2% ethyl cellulose, having a viscosity grade of from about 10 to about 20 centipoises; and
Claim 15
Dependent Claim
17 words
about 22.2% ethyl cellulose, having a viscosity grade of from about 10 to about 20 centipoises; and
Claim 16
Dependent Claim
12 words
from about 10 to about 23% by weight of ethyl cellulose; and
Claim 17
Dependent Claim
12 words
from about 10 to about 23% by weight of ethyl cellulose; and
Claim 18
Dependent Claim
12 words
from about 5 to about 35% by weight of ethyl cellulose; and
Claim 19
Dependent Claim
12 words
from about 5 to about 35% by weight of ethyl cellulose; and
Claim 20
Dependent Claim
13 words
FROM ABOUT 5 TO ABOUT 35% BY WEIGHT OF AT LEAST ONE AND
Claim 21
Dependent Claim
13 words
FROM ABOUT 5 TO ABOUT 35% BY WEIGHT OF AT LEAST ONE AND
Claim 22
Dependent Claim
35 words
FROM ABOUT 15 TO ABOUT 45% BY WEIGHT OF AT LEAST ONE COATING INGREDIENT SELECTED FROM A GROUP CONSISTING OF POLYETHYLENE GLYCOL POLYMERS HAVING AN AVERAGE MOLECULAR WEIGHT OF FROM ABOUT 200 TO ABOUT 20,000.
Claim 23
Dependent Claim
35 words
FROM ABOUT 15 TO ABOUT 45% BY WEIGHT OF AT LEAST ONE COATING INGREDIENT SELECTED FROM A GROUP CONSISTING OF POLYETHYLENE GLYCOL POLYMERS HAVING AN AVERAGE MOLECULAR WEIGHT OF FROM ABOUT 200 TO ABOUT 20,000.
Claim 24
Dependent Claim
35 words
from about 15 to about 45% by weight of at least one coating ingredient selected from a group consisting of polyethylene glycol polymers having an average molecular weight of from about 200 to about 20,000.
Claim 25
Dependent Claim
35 words
from about 15 to about 45% by weight of at least one coating ingredient selected from a group consisting of polyethylene glycol polymers having an average molecular weight of from about 200 to about 20,000.
Claim 26
Dependent Claim
20 words
about 33.3% of a polyethylene glycol polymer ingredient having an average molecular weight of from about 6,000 to about 7,500.
Claim 27
Dependent Claim
20 words
about 33.3% of a polyethylene glycol polymer ingredient having an average molecular weight of from about 6,000 to about 7,500.
Claim 28
Dependent Claim
36 words
A substantially tasteless suspension according to claim 2 wherein the ethyl cellulose ingredient has an ethoxy content of from about 43 to about 51%, and a viscosity grade of from about 6 to about 350 centipoises.
Claim 29
Dependent Claim
35 words
from about 15 to about 35% by weight of at least one coating ingredient selected from a group consisting of polyethylene glycol polymers having an average molecular weight of from about 200 to about 20,000.
Claim 30
Dependent Claim
35 words
from about 15 to about 35% by weight of at least one coating ingredient selected from a group consisting of polyethylene glycol polymers having an average molecular weight of from about 200 to about 20,000.
Claim 31
Dependent Claim
24 words
A substantially tasteless suspension according to claim 3 wherein the polyethylene glycol polymers have an average molecular weight of from about 950 to 7500.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-04-21 | 1978-10-21 | 1979-04-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-04-21 | 1982-10-21 | 1983-04-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-04-21 | 1986-10-21 | 1987-04-22 | $7700.00 | Window Closed / Lapsed |