US3879398A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Salts of a monophosphonic acid and a monoamine
Assignee: Glaxo Laboratories Ltd
•
Filing: 1973-01-12
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Granted: 1975-04-22
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Expires: 1993-01-12
Abstract
Abstract The invention relates to a process for the preparation of 7 Beta -acylamido-3-methylceph-3-em-4-carboxylic acid esters from 6 Beta -acylamido penicillanic acid 1-oxide esters in the presence of catalysts which are salts or complexes of acids with nitrogen bases having a pKb of not less than 4. The salts or complexes may be formed in situ.
Inventors
- 👤 Norman Vaughan Ellerton
- 👤 William Frederick Paradise
- 👤 Peter Edgar Sandord
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 00:31
CPC Classifications
B; B01; B01J; B01J31/00; B01J31/02; B01J31/0234; B01J31/0235; B01J31/0239; B01J31/0244; B01J31/0255; B01J31/0257; B01J31/0259; C; C07; C07D; C07D499/00; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/38; C07F9/3804; C07F9/3808
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
58 words
A salt of a monoamine selected from the group consisting of pyridine and pyridine substituted by a chlorine atom, a bromine atom, lower alkyl, formyl, acetyl, acetamide, cyano, aldoximino, and a phosphonic acid selected from the group consisting of methane phosphonic acid, ethane phosphonic acid, trichloromethane phosphonic acid, iodomethane phosphonic acid, dichloromethane phosphonic acid and bromobenzene phosphonic acid.
Claim 2
Dependent Claim
58 words
A salt of a monoamine selected from the group consisting of pyridine and pyridine substituted by a chlorine atom, a bromine atom, lower alkyl, formyl, acetyl, acetamide, cyano, aldoximino, and a phosphonic acid selected from the group consisting of methane phosphonic acid, ethane phosphonic acid, trichloromethane phosphonic acid, iodomethane phosphonic acid, dichloromethane phosphonic acid and bromobenzene phosphonic acid.
Claim 3
Dependent Claim
57 words
A SALT OF A MONOAMINE SELECTED FROM THE GROUP CONSISTING OF PYRIDINE AND PYRIDINE SUBSTITUTED BY A CHLORINE ATOM, A BROMINE ATOM,LOWER ALKYL, FORMYL, ACETYL, ACETAMIDE, CYANO, ALDOXIMINO, AND A PHOSPHONIC ACID SELECTED FROM THE GROUP CONSISTING OF METHANE PHOSPHONIC ACID, ETHANE PHOSPHONIC ACID, TRICHLOROMETHANE PHOSPHONIC ACID, IODOMETHANE PHOSPHONIC ACID, DICHLOROMETHANE PHOSPHONIC ACID AND BROMOBENZENE PHOSPHONIC ACID.
Claim 4
Dependent Claim
57 words
A SALT OF A MONOAMINE SELECTED FROM THE GROUP CONSISTING OF PYRIDINE AND PYRIDINE SUBSTITUTED BY A CHLORINE ATOM, A BROMINE ATOM,LOWER ALKYL, FORMYL, ACETYL, ACETAMIDE, CYANO, ALDOXIMINO, AND A PHOSPHONIC ACID SELECTED FROM THE GROUP CONSISTING OF METHANE PHOSPHONIC ACID, ETHANE PHOSPHONIC ACID, TRICHLOROMETHANE PHOSPHONIC ACID, IODOMETHANE PHOSPHONIC ACID, DICHLOROMETHANE PHOSPHONIC ACID AND BROMOBENZENE PHOSPHONIC ACID.
Claim 5
Dependent Claim
22 words
A salt as defined in claim 1, wherein said monoamine is selected from the group consisting of pyridine and lower alkyl-substituted pyridines.
Claim 6
Dependent Claim
22 words
A salt as defined in claim 1 wherein the salt product consists essentially of substantially molar equivalents of monoamine and phosphonic acid.
Claim 7
Dependent Claim
27 words
A salt as defined in claim 1 wherein the salt product consists essentially of about two molar equivalents of monoamine and one molar equivalent of phosphonic acid.
Claim 8
Dependent Claim
10 words
The salt of claim 1 which is pyridinium trichloromethane phosphonate.
Claim 9
Dependent Claim
11 words
The salt of claim 1 which is Alpha -picolinium trichloromethane phosphonate.
References Cited (Backward Citations)
US3243482A
Cited
US3324110A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-04-21 | 1978-10-21 | 1979-04-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-04-21 | 1982-10-21 | 1983-04-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-04-21 | 1986-10-21 | 1987-04-22 | $7700.00 | Window Closed / Lapsed |