US3878185A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pepsin inhibitors and preparation thereof
Assignee: Individual
•
Filing: 1971-04-28
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Granted: 1975-04-15
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Expires: 1991-04-28
Abstract
Abstract New substances named ''''substance S-PI'''' and ''''substance Me SPI'''' are concerned which are effective as pepsin inhibitor, the latter substance being methyl ester of the former. The substance S-PI is prepared by fermentation of a new strain of microorganism which has been isolated from soil by the present inventors and named the Streptomyces naniwaensis (EF 44-201), whereas the substance Me S-PI is prepared by methyl esterifying the former substance. A specimen of the Streptomyces naniwaensis (EF 44-201) has been deposited to the American Type Culture Collection under the assinged Number ATCC 21689.
Inventors
- 👤 Sawao Murao
- 👤 Shuzo Satoi
- 👤 Noriaki Kuwana
- 👤 Masayuki Fukumura
- 👤 Tamio Kawamura
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 12:08
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/55; A61K38/57; C; C07; C07K; C07K14/00; C07K14/81; C07K14/8107; C07K14/8142; C12; C12P; C12P21/00; C12P21/02; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/886
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
82 words
A PEPSIN INHIBITOR S-PI WHICH IS ACIDIC: SOLUBLE IN WATER AND AQUEOUS ALKALI; INSOLUBLE IN BENZENE, ETHER, PETROLEUM, ETHER, CHLOROFORM, CARBON TETRACHLORIDE, BEXANE AND ETHYL ACETATE; REACTING NEGATIVELY IN THE NINHYDRIN TEST, BUT POSITIVELY AFTER HYDROYLSIS; CONVERTIBLE TO A METHYL ESTER BY REACTION WITH DIAZOMETHANE IN THE PRESENCE OF HYDROGEN CHLORIDE, CONVERTIBLE TO A METHYL ESTER BY REACTION WITH DIAZOMETHANE IN THE PRESENCE OF HYDROGEN CHLORIDE; AND EXHIBITING AN INFRARED CURVE SUBSTANTIALLY AS SHOWN IN FIG.1 HEREOF IN A POTASSIUM BROMIDE TABLET.
Claim 2
Dependent Claim
82 words
A PEPSIN INHIBITOR S-PI WHICH IS ACIDIC: SOLUBLE IN WATER AND AQUEOUS ALKALI; INSOLUBLE IN BENZENE, ETHER, PETROLEUM, ETHER, CHLOROFORM, CARBON TETRACHLORIDE, BEXANE AND ETHYL ACETATE; REACTING NEGATIVELY IN THE NINHYDRIN TEST, BUT POSITIVELY AFTER HYDROYLSIS; CONVERTIBLE TO A METHYL ESTER BY REACTION WITH DIAZOMETHANE IN THE PRESENCE OF HYDROGEN CHLORIDE, CONVERTIBLE TO A METHYL ESTER BY REACTION WITH DIAZOMETHANE IN THE PRESENCE OF HYDROGEN CHLORIDE; AND EXHIBITING AN INFRARED CURVE SUBSTANTIALLY AS SHOWN IN FIG.1 HEREOF IN A POTASSIUM BROMIDE TABLET.
Claim 3
Dependent Claim
38 words
A pepsin inhibitor Me S-PI which is neutral in electrophoresis; soluble in methanol; insoluble in benzene, ether, petroleum ether and chloroform; and exhibiting an infrared curve substantially as shown in FIG. 2 hereof in a potassium bromide tablet.
Claim 4
Dependent Claim
38 words
A pepsin inhibitor Me S-PI which is neutral in electrophoresis; soluble in methanol; insoluble in benzene, ether, petroleum ether and chloroform; and exhibiting an infrared curve substantially as shown in FIG. 2 hereof in a potassium bromide tablet.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-04-14 | 1978-10-14 | 1979-04-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-04-14 | 1982-10-14 | 1983-04-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-04-14 | 1986-10-14 | 1987-04-15 | $7700.00 | Window Closed / Lapsed |