US3876816A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Nonabsorbable, nonnutritive sweeteners
Assignee: Dynapol Shareholders Liquidating Trust
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Filing: 1972-10-25
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Granted: 1975-04-08
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Expires: 1992-10-25
Abstract
Abstract Novel, nonabsorbable nonnutritive sweeteners of the general formula (Am).sub.n C wherein Am is a means for producing a sweetening response in a sensory environment, C is a means for essentially controlling the absorption of Am in a biological environment, .about. is a means for permanently covalently bonding Am to C, and n is at least one. The nonabsorbable nonnutritive sweeteners are useful for producing a sweet effect without any substantial absorption of the nonabsorbable nonnutritive sweetener in the biological environment.
Inventors
- 👤 Alejandro Zaffaroni
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 16:54
CPC Classifications
C; C07; C07D; C07D303/00; C07D303/02; C07D303/12; C07D303/18; C07D303/20; C07D303/22; A; A23; A23L; A23L27/00; A23L27/70; A23L27/75; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/58; A61K47/59; A61K47/60; A61K47/61; C07D303/24; C07H; C07H15/00; C07H15/02; C07H15/04; C07H15/10
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
127 words
A NONABSORBABLE, NONNUTRITIVE, WATER-SOLUBLE SWEETENER COMPOSITION COMPRISED OF AN ACTIVE SWEETENING AGENT COVALENTLY BONDED THROUGH A POSITION ON THE ACTIVE SWEETENING AGENT THAT IS NONESSENTIAL FOR ITS SWEETENING ACTIVITY, WITH A CONVALENT BOND THAT IS CAPABLE OF MAINTAINING ITS PHYSICAL AND CHEMICAL INTEGRITY UNDER THE CONDITIONS OF PASSAGE THROUGH THE GASTOINTESTINAL TRACT, TO A NONMETABOLIZABLE CONTROLLER MOLECULE WHICH HAS A MOLECULAR WEIGHT IN EXCESS OF 1,000 AND AT LEAST ONE THREE-DIMENSIONAL SPACE-OCCUPYING GROUP SO AS TO BE TOO LARGE TO BE ABSORBED THROUGH THE MUCOSA OF THE GASTROINTESTINAL TRACT AND WHICH THEREBY MAINTAINS THE ACTIVE SWEETENING AGENT WITHIN THE GASTROINTESTINAL TRACT BY SUBSTANTIALLY RESTRICTING THE AGENT''S PASSAGE FROM THE MUCOSAL TO THE SEROSAL SIDE OF THE GASTROINTESTINAL TRACT AS THE SWEETENER COMPOSITION PASSES THROUGH THE GSTROINTESTINAL TRACT.
Claim 2
Dependent Claim
127 words
A NONABSORBABLE, NONNUTRITIVE, WATER-SOLUBLE SWEETENER COMPOSITION COMPRISED OF AN ACTIVE SWEETENING AGENT COVALENTLY BONDED THROUGH A POSITION ON THE ACTIVE SWEETENING AGENT THAT IS NONESSENTIAL FOR ITS SWEETENING ACTIVITY, WITH A CONVALENT BOND THAT IS CAPABLE OF MAINTAINING ITS PHYSICAL AND CHEMICAL INTEGRITY UNDER THE CONDITIONS OF PASSAGE THROUGH THE GASTOINTESTINAL TRACT, TO A NONMETABOLIZABLE CONTROLLER MOLECULE WHICH HAS A MOLECULAR WEIGHT IN EXCESS OF 1,000 AND AT LEAST ONE THREE-DIMENSIONAL SPACE-OCCUPYING GROUP SO AS TO BE TOO LARGE TO BE ABSORBED THROUGH THE MUCOSA OF THE GASTROINTESTINAL TRACT AND WHICH THEREBY MAINTAINS THE ACTIVE SWEETENING AGENT WITHIN THE GASTROINTESTINAL TRACT BY SUBSTANTIALLY RESTRICTING THE AGENT''S PASSAGE FROM THE MUCOSAL TO THE SEROSAL SIDE OF THE GASTROINTESTINAL TRACT AS THE SWEETENER COMPOSITION PASSES THROUGH THE GSTROINTESTINAL TRACT.
Claim 3
Dependent Claim
21 words
A nonabsorbable, nonnutritive sweetener according to claim 1 wherein the controller molecule has a molecular weight of from 15,000 to 500,000.
Claim 4
Dependent Claim
99 words
A nonabsorbable, nonnutritive, water-soluble sweetener composition of the general formula (Am).about..sub.n C wherein Am is a sweetening agent capable of stimulating a sweet response on contacting a sensory receptor in a warm-blooded animal, .about. is a covalent bond that couples Am to C and is capable of substantially resisting rupture under the conditions of passage through the gastrointestinal tract, n is at least one and C is a polymeric, nonbiodegradable matrix having a molecular weight of from 15,000 to 500,000 and molecular dimensions that substantially prevent passage of the sweetener composition from the gastrointestinal lumen into the systemic circulation.
Claim 5
Dependent Claim
99 words
A nonabsorbable, nonnutritive, water-soluble sweetener composition of the general formula (Am).about..sub.n C wherein Am is a sweetening agent capable of stimulating a sweet response on contacting a sensory receptor in a warm-blooded animal, .about. is a covalent bond that couples Am to C and is capable of substantially resisting rupture under the conditions of passage through the gastrointestinal tract, n is at least one and C is a polymeric, nonbiodegradable matrix having a molecular weight of from 15,000 to 500,000 and molecular dimensions that substantially prevent passage of the sweetener composition from the gastrointestinal lumen into the systemic circulation.
Claim 6
Independent Claim
123 words
A method of producing a sweet response in a warm-blooded animal comprised of contacting a taste receptor of said animal with an amount of a nonabsorbable, nonnutritive, water-soluble sweetener composition of the general formula (Am).about..sub.n C wherein Am is a sweetening agent capable of sitmulating a sweet response on contacting a sensory receptor in a warm-blooded animal, .about. is a covalent bond that couples Am to C and is capable of substantially resisting rupture under the conditions of passage through the gastrointestinal track, n is at least one and C is a polymeric, nonbiodegradable matrix having a molecular weight of from 15,000 to 500,000 and molecular dimensions that substantially prevent passage of the sweetener composition from the gastrointestinal lumen into the systemic circulation.
Claim 7
Independent Claim
123 words
A method of producing a sweet response in a warm-blooded animal comprised of contacting a taste receptor of said animal with an amount of a nonabsorbable, nonnutritive, water-soluble sweetener composition of the general formula (Am).about..sub.n C wherein Am is a sweetening agent capable of sitmulating a sweet response on contacting a sensory receptor in a warm-blooded animal, .about. is a covalent bond that couples Am to C and is capable of substantially resisting rupture under the conditions of passage through the gastrointestinal track, n is at least one and C is a polymeric, nonbiodegradable matrix having a molecular weight of from 15,000 to 500,000 and molecular dimensions that substantially prevent passage of the sweetener composition from the gastrointestinal lumen into the systemic circulation.
Claim 8
Dependent Claim
114 words
A comestible composition of matter comprising a nonabsorbable, nonnutritive, water-soluble sweetener composition of the general formula (Am).about..sub.n C wherein Am is a sweetening agent capable of stimulating a sweet response on contacting a sensory receptor in a warm-blooded animal, .about. is a covalent bond that couples Am to C and is capable of substantially resisting rupture under the conditions of passage through the gastrointestinal tract, n is at least one and C is a polymeric, nonbiodegradable matrix having a molecular weight of from 15,000 to 500,000 and molecular dimensions that substantially prevent passage of the sweetener composition from the gastrointestinal lumen into the systemic circulation, admixed in an effective amount with an edible substance.
Claim 9
Dependent Claim
114 words
A comestible composition of matter comprising a nonabsorbable, nonnutritive, water-soluble sweetener composition of the general formula (Am).about..sub.n C wherein Am is a sweetening agent capable of stimulating a sweet response on contacting a sensory receptor in a warm-blooded animal, .about. is a covalent bond that couples Am to C and is capable of substantially resisting rupture under the conditions of passage through the gastrointestinal tract, n is at least one and C is a polymeric, nonbiodegradable matrix having a molecular weight of from 15,000 to 500,000 and molecular dimensions that substantially prevent passage of the sweetener composition from the gastrointestinal lumen into the systemic circulation, admixed in an effective amount with an edible substance.
Claim 10
Dependent Claim
16 words
The comestible composition of matter according to claim 5 wherein the edible substance is a foodstuff.
Claim 11
Independent Claim
158 words
A method of sweetening a comestible composition of matter, which method is comprised of adding to said comestible composition of matter an effective amount to impart sweetness of a nonabsorbable, nonnutritive, water-soluble sweetener composition comprised of an active sweetening agent covalently bonded through a position on the sweetening agent that is nonessential for its sweetening activity, with a covalent bond that is capable of maintaining its physical and chemical integrity under the conditions of passage through the gastrointestinal tract, to a nonmetabolizable controller molecule which has a molecular weight in excess of 1,000 and at least one three-dimensional space-occupying group so as to be too large to be absorbed through the mucosa of the gastrointestinal tract and which thereby maintains the active sweetening agent within the gastrointestinal tract by substantially restricting the agent''s passage from the mucosal to the serosal side of the gastrointestinal tract as the sweetener composition of said comestible substance pass through the gastrointestinal tract.
Claim 12
Independent Claim
158 words
A method of sweetening a comestible composition of matter, which method is comprised of adding to said comestible composition of matter an effective amount to impart sweetness of a nonabsorbable, nonnutritive, water-soluble sweetener composition comprised of an active sweetening agent covalently bonded through a position on the sweetening agent that is nonessential for its sweetening activity, with a covalent bond that is capable of maintaining its physical and chemical integrity under the conditions of passage through the gastrointestinal tract, to a nonmetabolizable controller molecule which has a molecular weight in excess of 1,000 and at least one three-dimensional space-occupying group so as to be too large to be absorbed through the mucosa of the gastrointestinal tract and which thereby maintains the active sweetening agent within the gastrointestinal tract by substantially restricting the agent''s passage from the mucosal to the serosal side of the gastrointestinal tract as the sweetener composition of said comestible substance pass through the gastrointestinal tract.
Claim 13
Independent Claim
142 words
A method of sweetening a comestible composition of matter, which method is comprised of adding to said comestible composition of matter an effective amount to impart sweetness of a nonabsorbable, nonnutritive, water-soluble sweetener of the general formula (Am) .about..sub.n C wherein Am is a sweetening agent capable of stimulating a sweet response on contacting a sensory receptor in a warm-blooded animal, .about. is a covalent bond that couples Am to C and is capable of substantially resisting rupture under the conditions of passage through the gastrointestinal tract, n is at least one and C is a polymeric, nonbiodegradable matrix having a molecular weight of from 15,000 to 500,000 and molecular dimensions that substantially prevent passage of the sweetener composition from the gastrointestinal lumen into the systemic circulation, as the sweetener composition and the comestible composition of matter pass through the gastrointestinal tract.
Claim 14
Independent Claim
142 words
A method of sweetening a comestible composition of matter, which method is comprised of adding to said comestible composition of matter an effective amount to impart sweetness of a nonabsorbable, nonnutritive, water-soluble sweetener of the general formula (Am) .about..sub.n C wherein Am is a sweetening agent capable of stimulating a sweet response on contacting a sensory receptor in a warm-blooded animal, .about. is a covalent bond that couples Am to C and is capable of substantially resisting rupture under the conditions of passage through the gastrointestinal tract, n is at least one and C is a polymeric, nonbiodegradable matrix having a molecular weight of from 15,000 to 500,000 and molecular dimensions that substantially prevent passage of the sweetener composition from the gastrointestinal lumen into the systemic circulation, as the sweetener composition and the comestible composition of matter pass through the gastrointestinal tract.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-04-07 | 1978-10-07 | 1979-04-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-04-07 | 1982-10-07 | 1983-04-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-04-07 | 1986-10-07 | 1987-04-08 | $7700.00 | Window Closed / Lapsed |