US3876787A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for lowering blood pressure in mammals
Assignee: Wyeth Holdings LLC
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Filing: 1973-08-27
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Granted: 1975-04-08
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Expires: 1993-08-27
Abstract
Abstract This disclosure describes a method of lowering blood pressure in mammals by the administration of compositions containing as the active component certain 6-(substituted-phenyl)-4,5-dihydro-3(2H) -pyridazinones.
Inventors
- 👤 Francis Joseph Mcevoy
- 👤 Jr George Rodger Allen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 21:12
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61K31/50
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
48 words
A THERAPEUTIC COMPOSITION IN DOSAGE UNIT FORM USEFUL FOR LOWERING BLOOD PRESSURE IN MAMMALS COMPRISING FROM ABOUT 50 MG. TO ABOUT 1.0 GRAM PER DAILY DOSAGE UNIT OF A COMPOUND SELECTED FROM THE GROUP CONSISTING OF 4,5-DIHYDRO-66-(PMETHYLAMINOPHENYL)-3(2H)-PYRIDAZINONE AND THE PHARMACOLOGICALLY ACCEPTABLE ACID-ADDITION SALTS THEREOF, AND A PHARMACEUTICAL CARRIER.
Claim 2
Dependent Claim
48 words
A THERAPEUTIC COMPOSITION IN DOSAGE UNIT FORM USEFUL FOR LOWERING BLOOD PRESSURE IN MAMMALS COMPRISING FROM ABOUT 50 MG. TO ABOUT 1.0 GRAM PER DAILY DOSAGE UNIT OF A COMPOUND SELECTED FROM THE GROUP CONSISTING OF 4,5-DIHYDRO-66-(PMETHYLAMINOPHENYL)-3(2H)-PYRIDAZINONE AND THE PHARMACOLOGICALLY ACCEPTABLE ACID-ADDITION SALTS THEREOF, AND A PHARMACEUTICAL CARRIER.
Claim 3
Dependent Claim
33 words
A therapeutic composition in dosage unit form useful for lowering blood pressure in mammals comprising from about 50 mg. to about 1.0 gram per daily dosage unit of N-ethyl-4''-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)acetanilide and a pharmaceutical carrier.
Claim 4
Dependent Claim
33 words
A therapeutic composition in dosage unit form useful for lowering blood pressure in mammals comprising from about 50 mg. to about 1.0 gram per daily dosage unit of N-ethyl-4''-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)acetanilide and a pharmaceutical carrier.
Claim 5
Independent Claim
64 words
The method of lowering blood pressure in a mammal which comprises administering internally to said mammal an effective amount of a compound selected from the group consisting of 4,5-dihydro-6-(p-methylaminophenyl)-3(2H)-pyridazinone and the pharmacologically acceptable acid-addition salts thereof, in association with a pharmaceutical carrier to provide a daily dosage of from about one mg. to about 15 mg. per kilogram of body weight of said mammal.
Claim 6
Independent Claim
64 words
The method of lowering blood pressure in a mammal which comprises administering internally to said mammal an effective amount of a compound selected from the group consisting of 4,5-dihydro-6-(p-methylaminophenyl)-3(2H)-pyridazinone and the pharmacologically acceptable acid-addition salts thereof, in association with a pharmaceutical carrier to provide a daily dosage of from about one mg. to about 15 mg. per kilogram of body weight of said mammal.
Claim 7
Independent Claim
50 words
The method of lowering blood pressure in a mammal which comprises administering internally to said mammal an effective amount of N-ethyl-4''-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl) acetanilide in association with a pharmaceutical carrier to provide a daily dosage of from about one mg. to about 15 mg. per kilogram of body weight of said mammal.
Claim 8
Independent Claim
50 words
The method of lowering blood pressure in a mammal which comprises administering internally to said mammal an effective amount of N-ethyl-4''-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl) acetanilide in association with a pharmaceutical carrier to provide a daily dosage of from about one mg. to about 15 mg. per kilogram of body weight of said mammal.
References Cited (Backward Citations)
US3475431A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-04-07 | 1978-10-07 | 1979-04-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-04-07 | 1982-10-07 | 1983-04-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-04-07 | 1986-10-07 | 1987-04-08 | $7700.00 | Window Closed / Lapsed |