US3875149A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Oximes of 1-(ortho-acyl-phenoxy)-2-hydroxy-3-aminopropanes
Assignee: May and Baker Ltd
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Filing: 1972-12-19
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Granted: 1975-04-01
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Expires: 1992-12-19
Abstract
Abstract Oximes of the formula: WHEREIN R is hydrogen or phenyl, R1 is hydrogen, alkyl of up to 6 carbon atoms, or hydroxyalkyl of up to 6 carbon atoms, R2 is alkyl of up to 6 carbon atoms, or hydroxyalkyl of up to 6 carbon atoms, or R1 and R2 together with the nitrogen to which they are attached represent morpholino, R3 is hydrogen, or alkyl of up to 6 carbon atoms, and R5 is hydrogen or phenylalkyl of up to 6 carbon atoms in the alkyl residue, and non-toxic acid addition salts thereof, possess pharmacodynamic properties of value in the treatment of prophylaxis of various cardiac disorders, especially cardiac arrhythmias.
Inventors
- 👤 Kenneth Robert Harry Wooldridge
- 👤 Berkeley Basil
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 05:17
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/24; C07D213/44; C07D213/53; C07C; C07C251/00; C07C251/72; C07C45/00; C07C45/004; C07C45/27; C07C45/29; C07C45/292; C07C45/51; C07C45/54; C07C45/61; C07C45/67; C07C45/673; C07C49/00; C07C49/76; C07C49/84; C07D213/46; C07D213/50; C07D303/00; C07D303/02; C07D303/12; C07D303/18; C07D303/20; C07D303/22; C07D303/24
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
5 words
AN OXIME OF THE FORMULA:
Claim 2
Dependent Claim
5 words
AN OXIME OF THE FORMULA:
Claim 3
Dependent Claim
30 words
An oxime according to claim 1 wherein R1 and R2 are both methyl, or propyl or 2-hydroxyethyl, R3 is hydrogen and R5 is benzyl, and non-toxic acid addition salts thereof.
Claim 4
Dependent Claim
20 words
An oxime according to claim 1 selected from the class consisting of DL-1-(o-acetylphenoxy)-2-hydroxy-3-isopropylaminopropane O-benzyloxime, and non-toxic acid addition salts thereof.
Claim 5
Dependent Claim
19 words
An oxime according to claim 1 selected from class consisting of DL-1-(o-formylphenoxy)-2-hydroxy-3-isopropylaminopropane O-benzyloxime, and non-toxic acid addition salts thereof.
Claim 6
Dependent Claim
20 words
An oxime according to claim 1 selected from the class consisting of DL-1-(o-formylphenoxy)-2-hydroxy-3-morpholinopropane O-benzyloxime, and non-toxic acid addition salts thereof.
Claim 7
Dependent Claim
20 words
An oxime according to claim 1 selected from the class consisting of DL-1-(o-acetylphenoxy)-2-hydroxy-3-morpholinopropane O-benzyloxime, and non-toxic acid addition salts thereOf.
Claim 8
Dependent Claim
20 words
An oxime according to claim 1 selected from the class consisting of DL-1-(o-formylphenoxy)-2-hydroxy-3-diethylaminopropane O-benzyloxime, and non-toxic acid addition salts thereof.
Claim 9
Dependent Claim
20 words
An oxime according to claim 1 selected from the class consisting of DL-1-(o-acetylphenoxy)-2-hydroxy-3-diethylaminopropane oxime, and non-toxic acid addition salts thereof.
Claim 10
Dependent Claim
20 words
An oxime according to claim 1 selected from the class consisting of DL-1-(o-formylphenoxy)-2-hydroxy-3-dimethylaminopropane O-benzyloxime, and non-toxic acid addition salts thereof.
Claim 11
Dependent Claim
20 words
An oxime according to claim 1 selected from the class consisting of DL-1-(o-formylphenoxy)-2-hydroxy-3-di-n-propylaminopropane O-benzyloxime, and non-toxic acid addition salts thereof.
Claim 12
Dependent Claim
20 words
An oxime according to claim 1 selected from the class consisting of DL-1-(o-formylphenoxy)-2-hydroxy-3-di(2-hydroxyethyl)aminopropane O-benzyloxime and non-toxic acid addition salts thereof.
Claim 13
Dependent Claim
20 words
An oxime according to claim 1 selected from the class consisting of DL-1-(2-acetyl-4-phenylphenoxy)-2-hydroxy-3-isopropylaminopropane oxime and non-toxic acid addition salts thereof.
Claim 14
Dependent Claim
64 words
An oxime according to claim 1 wherein R is hydrogen, R1 and R2 are both methyl, ethyl or n-propyl, or one of R1 and R2 is hydrogen and the other is isopropyl, or R1 and R2 together with the nitrogen to which they are attached represent morpholino, R3 is hydrogen or methyl, and R5 is hydrogen or benzyl, and non-toxic acid addition salts thereof.
References Cited (Backward Citations)
US2774766A
Cited
US3732277A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-03-31 | 1978-09-30 | 1979-04-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-03-31 | 1982-09-30 | 1983-04-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-03-31 | 1986-09-30 | 1987-04-01 | $7700.00 | Window Closed / Lapsed |