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US3875148A Expired / Lapsed US ⏱️ 0.0 years remaining

9{60 -unsubstituted-11{62 -bromo-19-norsteroids

Assignee: Laboratoire Glaxo Wellcome SA
•
Filing: 1974-02-19
•
Granted: 1975-04-01
•
Expires: 1994-02-19
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Abstract

Abstract WHERE R1 and R2 are alkyl groups having 1-8 carbon atoms or aralkyl or aryl groups or, together with the nitrogen atom to which they are attached, comprise a heterocyclic radical; R3 is a bromine or fluorine atom; R4 is a bromine or fluorine atom and R5 is hydrogen or R4 and R5 together represent a carbon-carbon bond; R6 is a chlorine, bromine or fluorine atom and R7 is a chlorine, bromine or fluorine atom or a trifluoromethyl group, the reaction being effected in the presence of bromide ions when neither R3 nor R4 is bromine; or (b) with a triarylphosphine or -phosphite and bromine or bromalkane. 9 Alpha -UNSUBSTITUTED-11 Beta -BROMO-19-NOR-STEROIDS HAVING HORMONAL ACTIVITY AND A PROCESS FOR PREPARING SAME BY REACTING THE CORRESPONDING 11 Alpha -HYDROXY STEROID WITH A. A REAGENT OF THE FORMULA

Inventors

  • 👤 Joseph Elks
  • 👤 Gordon Hanley Phillipps
  • 👤 Alan Tulley
  • 👤 Leslie Stephenson
  • 👤 Margaret Elizabeth Hill

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-04 10:28
CPC Classifications
C; C07; C07J; C07J1/00; C07J1/0051; C07J1/0059; C07J1/0081; C07J1/0088; C07J1/0096; C07J7/00; C07J7/0005; C07J7/001; C07J7/004; C07J7/0045; C07J9/00

Claims Analysis

Total Claims: 11
Claim 1
Independent Claim 18 words
A 9A-UNSUBSTITUTED-11B-BROMO-19-NOR-STERIOD OF THE ANDROSTANE OR PREGNANE SERIES SELECTED FROM THE GROUP CONSISTING OF THOSE OF THE FORMULA
Claim 2
Dependent Claim 18 words
A 9A-UNSUBSTITUTED-11B-BROMO-19-NOR-STERIOD OF THE ANDROSTANE OR PREGNANE SERIES SELECTED FROM THE GROUP CONSISTING OF THOSE OF THE FORMULA
Claim 3
Dependent Claim 31 words
A steroid as claimed in claim 1 in which the ketal groups are ethylenedioxy groups and in which the enol ether groups are enol methyl ether or enol ethyl ether groups.
Claim 4
Dependent Claim 26 words
A steroid as claimed in claim 1 in which the aliphatic group is a methyl, ethyl, propyl, vinyl, 2-methyl-prop2-enyl, 1-methyl-prop-2-enyl, but-2-enyl, allyl, ethynyl or chloroethynyl group.
Claim 5
Dependent Claim 12 words
The compound of claim 1 which is 11 Beta -bromo oestr-4-ene-3, 17-dione.
Claim 6
Dependent Claim 12 words
The compound of claim 1 which is 17 Alpha -acetoxy-11 Beta -bromo-19-norpregn-4-ene-3,20-dione.
Claim 7
Dependent Claim 14 words
The compound of claim 1 which is 11 Beta -bromo-17 Alpha -ethynyl-17 Beta -hydroxyoestr-4-en-3-one.
Claim 8
Dependent Claim 14 words
The compound of claim 1 which is 11 Beta -bromo-3-ethoxy-17 Alpha -ethynyloestra-3,5-dien-17 Beta -ol.
Claim 9
Dependent Claim 12 words
The compound of claim 1 which is 17 Alpha -acetoxy-11 Beta -bromo-19-norpregna-4,6-diene-3,20-dione.
Claim 10
Dependent Claim 36 words
A process for the preparation of a 9 Alpha -unsubstituted 11 Beta -bromo-19-nor-steroid as defined in claim 1 in which a corresponding 9 Alpha -unsubstituted-11 Alpha -hydroxy-19-nor-steroid is reacted (a) with a reagent of the formula
Claim 11
Dependent Claim 33 words
A process as claimed in claim 9 in which the source of bromide ions in reaction (a) is a salt soluble in organic solvents, but having a cationic portion inert to the reagent.

References Cited (Backward Citations)

No citation records indexed.

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1978-03-31 1978-09-30 1979-04-01 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1982-03-31 1982-09-30 1983-04-01 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1986-03-31 1986-09-30 1987-04-01 $7700.00 Window Closed / Lapsed

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