US3875010A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for the preparation of daunorubicin
Assignee: Rhone Poulenc SA
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Filing: 1969-11-17
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Granted: 1975-04-01
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Expires: 1989-11-17
Abstract
Abstract The antibiotic daunorubicin is prepared by aerobically cultivating Streptomyces bifurcus, strain DS 23,219 (NRRL 3539), or a daunorubicin-producing mutant thereof, in an aqueous nutrient medium containing assimilable sources of carbon, nitrogen and inorganic substances, and separating daunorubicin formed during the culture.
Inventors
- 👤 Denise Mancy
- 👤 Jean Florent
- 👤 Homme Jean Preud
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 21:10
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/20; C07H15/24; C07H15/252; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/886; Y10S435/901
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
43 words
PROCESS FOR PRODUCTION OF DAUNORUBICIN WHICH COMPRISES AEROBICALLY CULTIVATING STREPTOMYCES BIFURCUS, STRAIN DS 23,219 (NRRL 3539), OR A DAUNORUBICIN-PRODUCING MUTANT THEREOF, USING AN AQUEOUS NUTROGEN AND INORGANIC SUBSTANCES, LABLE SOURCES OF CARBON, NITROGEN AND INORGANIC SUBSTANCES, AND SEPARATING DAUNORUBICIN FORMED DURING THE CULTURE.
Claim 2
Dependent Claim
43 words
PROCESS FOR PRODUCTION OF DAUNORUBICIN WHICH COMPRISES AEROBICALLY CULTIVATING STREPTOMYCES BIFURCUS, STRAIN DS 23,219 (NRRL 3539), OR A DAUNORUBICIN-PRODUCING MUTANT THEREOF, USING AN AQUEOUS NUTROGEN AND INORGANIC SUBSTANCES, LABLE SOURCES OF CARBON, NITROGEN AND INORGANIC SUBSTANCES, AND SEPARATING DAUNORUBICIN FORMED DURING THE CULTURE.
Claim 3
Dependent Claim
35 words
Process according to claim 1 in which the culture is effected under submerged aerobic culture conditions commencing at a pH within the range of 6.0 to 7.8 at a temperature of from 23* to 33*C.
Claim 4
Dependent Claim
24 words
Process according to claim 2 in which the pH of the nutrient medium at the beginning of the culture is from 6.5 to 7.5.
Claim 5
Dependent Claim
16 words
Process according to claim 2 in which the temperature of the culture is 25* to 30*C.
Claim 6
Dependent Claim
29 words
Process according to claim 2 in which the culture medium is aerated at a rate of from 0.3 to 3 litres of air per litre of medium per minute.
References Cited (Backward Citations)
GB985598A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-03-31 | 1978-09-30 | 1979-04-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-03-31 | 1982-09-30 | 1983-04-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-03-31 | 1986-09-30 | 1987-04-01 | $7700.00 | Window Closed / Lapsed |