US3872115A
Expired / Lapsed
US
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Cephalosporins
Assignee: Takeda Pharmaceutical Co Ltd
•
Filing: 1972-05-31
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Granted: 1975-03-18
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Expires: 1992-05-31
Abstract
Abstract WHEREIN R1 is an acyl group, R2 and R3 represent hydrogen, a lower alkyl group, carboxylic group, amino group, dimethylamino group or hydroxymethyl group, respectively, or R2 and R3 may be bonded to form -NH-CH N- group. These cephalosporins have a broad antimicrobial spectrum. They are, in particular, effective against colitis germs (Escherichia coli) at a lower concentration. Example thereof include 7-(2-thienylacetamido)-3(2-oxopyrimidin-4-ylthio)-methylceph-3-em-4 -carboxylic acid, 7(phenyl-acetamido)- 3-(2-oxopyrimidin-4-ylthio)-methylceph-3-em4-carboxylic acid, 7-(phenoxyacetamido)3-(2-oxopyrimidin-4ylthio)-methylceph-3-em-4-carboxylic acid and 7-(2-thienylacetamido)-3-(2-oxo-6-methylpyrimidin-4-ylthio)-methylceph-3-em4-carboxylic acid. Novel cephalosporin compounds of the formula,
Inventors
- 👤 Keiichi Sugimoto
- 👤 Kunio Kobayashi
- 👤 Kouji Nishijima
- 👤 Shiro Morimoto
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 03:16
CPC Classifications
C; C07; C07D; C07D501/00; C07D501/14; C07D501/16; C07D501/20; C07D501/24; C07D501/36; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/06; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 31
Claim 1
Independent Claim
5 words
A COMPOUND OF THE FORMULA
Claim 2
Dependent Claim
5 words
A COMPOUND OF THE FORMULA
Claim 3
Dependent Claim
11 words
A compound according to claim 1, wherein R1 is 2-thienylacetyl group.
Claim 4
Dependent Claim
11 words
A compound according to claim 1, wherein R1 is phenylacetyl group.
Claim 5
Dependent Claim
11 words
A compound according to claim 1, wherein R1 is phenylthioacetyl group.
Claim 6
Dependent Claim
14 words
A compound according to claim 1, wherein both R2 and R3 are hydrogen atoms.
Claim 7
Dependent Claim
21 words
A compound according to claim 1, wherein one of R2 and R3 is methyl group and the other is hydrogen atom.
Claim 8
Dependent Claim
10 words
A compound claimed in claim 1, namely 7-(2-thienylacetamido)-3-(2-oxopyrimidin-4-ylthio)-methylceph-3-em-4 -carboxylic acid.
Claim 9
Dependent Claim
9 words
A compound claimed in claim 1, namely 7-(phenylacetamido)-3-(2-oxopyrimidin-4-ylthio)-methylceph-3-em-4-carboxylic acid.
Claim 10
Dependent Claim
10 words
A compound claimed in claim 1, namely 7-(phenoxyacetamido)-3-(2-oxopyrimidin-4-ylthio)-methylceph-3-em-4 -carboxylic acid.
Claim 11
Dependent Claim
10 words
A cOmpound claimed in claim 1, namely 7-(2-thienylacetamido)-3-(2-oxo-6-methylpyrimidin-4-ylthio)-methylceph-3-em -4-carboxylic acid.
Claim 12
Dependent Claim
11 words
A compound according to claim 1, namely 7-( Alpha -carboxyphenylacetamido)-3-(2-oxo-5-methylpyrimidin-4-ylthio-methylceph-3-em-4-carboxylic acid.
Claim 13
Dependent Claim
12 words
A compound according to claim 1, wherein R4 is phenyl or thienyl.
Claim 14
Dependent Claim
10 words
A compound according to claim 12, wherein R4 is phenyl.
Claim 15
Dependent Claim
13 words
A compound according to claim 1, wherein R5 is amino, carboxyl or sulfo.
Claim 16
Dependent Claim
10 words
A compound according to claim 14, wherein R5 is carboxyl.
Claim 17
Dependent Claim
10 words
A compound according to claim 1, wherein R2 is methyl.
Claim 18
Dependent Claim
10 words
A compound according to claim 1, wherein R3 is hydrogen.
Claim 19
Dependent Claim
23 words
A compound according to claim 1, wherein said compound is an acid or a salt of sodium, potassium, magnesium, calcium, aluminum or triethylamine.
Claim 20
Dependent Claim
26 words
A compound according to claim 1, wherein R4 is selected from the group consisting of phenyl, phenoxy, thienyl and phenylthio and further wherein R5 is hydrogen.
Claim 21
Dependent Claim
10 words
A compound according to claim 19, wherein R4 is phenyl.
Claim 22
Dependent Claim
10 words
A compound according to claim 19, wherein R4 is phenoxy.
Claim 23
Dependent Claim
10 words
A compound according to claim 19, wherein R4 is thienyl.
Claim 24
Dependent Claim
10 words
A compound according to claim 19, wherein R4 is phenylthio.
Claim 25
Dependent Claim
14 words
A compound according to claim 19, wherein both R2 and R3 are hydrogen atoms.
Claim 26
Dependent Claim
23 words
A compound according to claim 19, wherein one of R2 and R3 is a methyl group and the other is a hydrogen atom.
Claim 27
Dependent Claim
10 words
A compound according to claim 19, wherein R2 is methyl.
Claim 28
Dependent Claim
10 words
A compound according to claim 19, wherein R3 is hydrogen.
Claim 29
Dependent Claim
24 words
A compound according to claim 19, wherein said compound is an acid or a salt of sodium, potassium, magnesium, calcium, aluminum or triethyl amine.
Claim 30
Dependent Claim
12 words
A compound according to claim 19, namely disodium 7-( Alpha -carboxyphenylacetamido)-3-(2-oxo-5-methylpyrimidin-4-ylthio)-methylceph-3 -em-4-carboxylate.
Claim 31
Dependent Claim
9 words
A compound according to claim 19, namely 7-(2-thienylacetamido)-3-(2-oxo-5-methyl-pyrimidin-4-ylthio)-methylceph-3-em-4-carboxylic acid.
References Cited (Backward Citations)
US3673183A
Cited
US3663540A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-03-17 | 1978-09-16 | 1979-03-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-03-17 | 1982-09-16 | 1983-03-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-03-17 | 1986-09-16 | 1987-03-18 | $7700.00 | Window Closed / Lapsed |