US3872098A
Expired / Lapsed
US
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1,n{hu 6{b ethenoadenosine cyclophosphate compounds
Assignee: Syntex USA LLC
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Filing: 1973-07-11
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Granted: 1975-03-18
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Expires: 1993-07-11
Abstract
Abstract New ethenoadenosine cyclicphosphate compounds are disclosed wherein the 1,N6 nitrogen atoms of the adenosine moiety bear an etheno or substituted etheno bridge group. Also disclosed are methods for the preparation of these compounds, which are useful as intracellular mediators of hormone effect in animals. 1,N6etheno-8-benzylthioadenosine 3'',5''-cyclicphosphate, 1,N6- Alpha propylethenoadenosine 3'',5''-cyclicphosphate, the 3''-cyclic ester of 1,N6-etheno-5''-deoxy-5''-dihydroxyphosphinylmethyladenosine, the 5''-cyclic ester of 1,N6-etheno-3''-deoxy-3''dihydroxyphosphinylmethyladenosine, 1, N6-etheno-9-(6-deoxy- Beta -D-allofuranosyl)adenine 3'',5''-cyclicphosphate, 1, N6-etheno-9(6-deoxy- Alpha -L-talofuranosyl)-adenine 3'',5''-cyclicphosphate, and 1, N6-etheno-5'',5''-di-C-methyladenosine 3'',5''-cyclicphosphate are illustrated as representative of the compound class.
Inventors
- 👤 Gordon H Jones
- 👤 John G Moffatt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 17:08
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/16; C07H19/20; C07C; C07C45/00; C07C45/61; C07C45/63; C07C45/67; C07C45/68; C07C47/00; C07C47/02; C07C47/14
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
10 words
A COMPOUND SELECTED FROM THOSE REPRESENTED BY THE FOLLOWING FORMULA:
Claim 2
Dependent Claim
10 words
A COMPOUND SELECTED FROM THOSE REPRESENTED BY THE FOLLOWING FORMULA:
Claim 3
Dependent Claim
14 words
A compound according to claim 1 wherein each of R1 and R2 is hydrogen.
Claim 4
Dependent Claim
14 words
A compound according to claim 1 wherein R1 is n-propyl and R2 is hydrogen.
Claim 5
Dependent Claim
14 words
A compound according to claim 1 wherein R1 is phenyl and R2 is hydrogen.
Claim 6
Dependent Claim
16 words
A compound according to claim 1 wherein R1 is hydrogen and R2 is n-propyl or phenyl.
Claim 7
Dependent Claim
29 words
A compound according to claim 1 wherein R3 is hydrogen or benzylthio, S is a sugar moiety of Formula (B) in which R4 is hydroxy and R5 is hydrogen.
Claim 8
Dependent Claim
27 words
A compound according to claim 1 wherein R3 is methylthio, S is a sugar moiety of Formula (B) in which R4 is hydroxy and R5 is hydrogen.
Claim 9
Dependent Claim
14 words
A compound according to claim 7 wherein each of R1 and R2 is hydrogen.
Claim 10
Dependent Claim
14 words
A compound according to claim 7 wherein R1 is n-propyl and R2 is hydrogen.
Claim 11
Dependent Claim
16 words
A compound according to claim 6 wherein R1 is n-propyl or hydrogen and R2 is hydrogen.
Claim 12
Dependent Claim
14 words
A compound according to claim 7 wherein R1 is phenyl and R2 is hydrogen.
Claim 13
Dependent Claim
23 words
A compound according to claim 1 wherein S is a sugar moiety of Formula (C) wherein R4 is hydroxy and R5 is hydrogen.
Claim 14
Dependent Claim
18 words
A compound according to claim 12 wherein each of R2 and R3 is hydrogen and R1 is n-propyl.
Claim 15
Dependent Claim
23 words
A compound according to claim 1 wherein S is a sugar moiety of Formula (D) wherein R4 is hydroxy and R5 is hydrogen.
Claim 16
Dependent Claim
18 words
A compound according to claim 14 wherein each of R2 and R3 is hydrogen and R1 is n-propyl.
Claim 17
Dependent Claim
15 words
A compound according to claim 1 wherein S is a sugar moiety of Formula (E).
Claim 18
Dependent Claim
10 words
A compound according to claim 16 wherein R3 is methylthio.
Claim 19
Dependent Claim
17 words
A compound according to claim 16 wherein R3 is hydrogen, R4 is hydroxy, and R5 is hydrogen.
Claim 20
Dependent Claim
20 words
A compound according to claim 18 wherein R1 is n-propyl, R2 is hydrogen, R6 is methyl, and R7 is hydrogen.
Claim 21
Dependent Claim
20 words
A compound according to claim 18 wherein R1 is n-propyl, R2 is hydrogen, R6 is hydrogen and R7 is methyl.
Claim 22
Dependent Claim
21 words
A compound according to claim 18 wherein R1 is n-propyl, R2 is hydrogen and each of R6 and R7 is methyl.
References Cited (Backward Citations)
US3712885A
Cited
US3558595A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-03-17 | 1978-09-16 | 1979-03-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-03-17 | 1982-09-16 | 1983-03-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-03-17 | 1986-09-16 | 1987-03-18 | $7700.00 | Window Closed / Lapsed |