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US3871895A Expired / Lapsed US ⏱️ 0.0 years remaining

Method for preparing smears of biological liquids

Assignee: Bayer Corp
•
Filing: 1973-06-29
•
Granted: 1975-03-18
•
Expires: 1993-06-29
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Abstract

Abstract Apparatus and method for preparing a smear of a biological fluid substance on a substrate, utilizing a ribbon having relatively small openings in at least one surface thereof which openings are of substantially uniform size and are arranged substantially uniformly both longitudinally and transversely of the ribbon throughout at least a portion of the ribbon. The method includes the steps of supporting the substrate for movement and supporting the ribbon by a support to close proximity to the substrate at a substance-applying station, for a run of the ribbon past a portion of the substrate. Further steps include introducing a relatively small quantity of the aforementioned substance between the aforementioned ribbon surface portion and the substrate at the substance-applying station to spread by capillarity in a direction transversely of the ribbon, and moving the substrate in a direction to smear the substance on the substrate.

Inventors

  • 👤 Stanford L Adler

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-05 05:54
CPC Classifications
G; G01; G01N; G01N1/00; G01N1/28; G01N1/2813; Y; Y10; Y10T; Y10T436/00; Y10T436/11; Y10T436/110833

Claims Analysis

Total Claims: 8
Claim 1
Independent Claim 107 words
A METHOD OF PREPARING A SMEAR ON A SUBSTRATE ELEMENT, UTILIZING A RIBBON ELEMENT, COMPRISING: SUPPORTING THE SUBSTRATE ELEMENT FOR MOVEMENT, SUPPORTING SAID RIBBON ELEMENT FOR MOVEMENTT IN CLOSE PROXIMITY TO THE SUBSTRATE ELEMENT AT A SAMPLE-APPLYING STATION, INTRODUCING A RELATIVELY SMALL QUANTITY OF A BIOLOGICAL LIQUID SAMPLE BETWEEN SAID RIBBON AND SUBSTRATE ELEMENTS AT SAID SAMPLE APPLYING STATION, SPREADING THE SAMPLE ACROSS AT LEAST THE CENTRAL PORTION OF SAID RIBBON ELENENT, DRAWING THE SAMPLE ON SAID SUBSTRATE ELEMENT BY MOVING ONE OF SAID ELEMENTS RELATIVELY TO THE OTHER, AND MOVING THE RIBBON ELEMENT BY ADVANCING IT TO PRESENT A FRESH PORTION THEREOF TO SAID SAMPLE-APPLYING STATION.
Claim 2
Independent Claim 107 words
A METHOD OF PREPARING A SMEAR ON A SUBSTRATE ELEMENT, UTILIZING A RIBBON ELEMENT, COMPRISING: SUPPORTING THE SUBSTRATE ELEMENT FOR MOVEMENT, SUPPORTING SAID RIBBON ELEMENT FOR MOVEMENTT IN CLOSE PROXIMITY TO THE SUBSTRATE ELEMENT AT A SAMPLE-APPLYING STATION, INTRODUCING A RELATIVELY SMALL QUANTITY OF A BIOLOGICAL LIQUID SAMPLE BETWEEN SAID RIBBON AND SUBSTRATE ELEMENTS AT SAID SAMPLE APPLYING STATION, SPREADING THE SAMPLE ACROSS AT LEAST THE CENTRAL PORTION OF SAID RIBBON ELENENT, DRAWING THE SAMPLE ON SAID SUBSTRATE ELEMENT BY MOVING ONE OF SAID ELEMENTS RELATIVELY TO THE OTHER, AND MOVING THE RIBBON ELEMENT BY ADVANCING IT TO PRESENT A FRESH PORTION THEREOF TO SAID SAMPLE-APPLYING STATION.
Claim 3
Dependent Claim 23 words
A method as defined in claim 1, wherein: said drawing of the sample on said substrate element is by moving the last-mentioned element.
Claim 4
Dependent Claim 29 words
A method as defined in claim 1, wherein: said introduction of said sample comprises applying it on said ribbon element at said sample-applying station and advancing said ribbon element.
Claim 5
Dependent Claim 17 words
A method as defined in claim 1, further including contacting said ribbon element with said substrate element.
Claim 6
Dependent Claim 31 words
A method as defined in claim 1, wherein said step of spreading said sample comprises spreading of said sample by capillarity between said ribbon and substrate elements at said sample-applying station.
Claim 7
Dependent Claim 55 words
A method as defined in claim 1, wherein: said sample is one of a series of such samples, said substrate element having sequential smear-receiving portions, and advancing said ribbon and substrate elements periodically for sequential introduction of said samples between sequential portions of said ribbon element and said sequential smear-receiving portions of said substrate element.
Claim 8
Dependent Claim 23 words
A method as defined in claim 6, further including sequentially collecting said portions of said ribbon element exposed to said samples for disposal.

References Cited (Backward Citations)

US3462286A Cited
US3493447A Cited
US3526536A Cited
US3667896A Cited
US3701337A Cited
US3796594A Cited
US3705048A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1978-03-17 1978-09-16 1979-03-18 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1982-03-17 1982-09-16 1983-03-18 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1986-03-17 1986-09-16 1987-03-18 $7700.00 Window Closed / Lapsed

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