US3870727A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Production of harringtonine and isoharringtonine
Assignee: United States Department of Agriculture
•
Filing: 1972-04-27
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Granted: 1975-03-11
•
Expires: 1992-04-27
Abstract
Abstract Alkaloids found to be chemotherapeutically active against certain strains of leukemia in mice are produced from Cephalotaxus harringtonia. The process includes extraction of plant parts with a polar solvent, partitioning the plant extracts between nonpolar and acidic aqueous solvents, making the aqueous portion basic, and removing the crude alkaloids from the basic aqueous solution. The crude alkaloids are purified and used in the treatment of leukemic mice.
Inventors
- 👤 Richard G Powell
- 👤 Jr Cecil R Smith
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 08:33
CPC Classifications
C; C07; C07D; C07D491/00; C07D491/12; C07D491/20
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
7 words
THE ALKALOID COMPOUND HAVING THE FOLLOWING STRUCTURE:
Claim 2
Dependent Claim
7 words
THE ALKALOID COMPOUND HAVING THE FOLLOWING STRUCTURE:
Claim 3
Dependent Claim
7 words
The alkaloid compound having the following structure:
Claim 4
Dependent Claim
7 words
The alkaloid compound having the following structure:
Claim 5
Dependent Claim
8 words
The alkaloid compound of claim 1 wherein R
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-03-10 | 1978-09-09 | 1979-03-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-03-10 | 1982-09-09 | 1983-03-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-03-10 | 1986-09-09 | 1987-03-11 | $7700.00 | Window Closed / Lapsed |