Phosphono substituted alkylcephalosporins

Abstract

Abstract AND THE NON-TOXIC CATIONIC SALTS THEREOF WHEREIN R1 is hydrogen, lower alkyl, phenyl and substituted phenyl wherein the substituent is lower alkyl, lower alkoxy, chloro, bromo, fluoro and trifluoromethyl; R2 is hydrogen; R1 and R2 together with the carbon atom to which they are attached represent cycloalkyl of from three to seven carbon atoms; R3 is hydrogen and acyloxy lower alkyl wherein the acyloxy moiety is lower alkanoyloxy, benzoyloxy and substituted benzoyloxy wherein the substituent is chloro, bromo, fluoro, lower alkyl, lower alkoxy and trifluoromethyl; EACH OF R4 and R5 is hydrogen, lower alkyl, substituted lower alkyl wherein the substituent is lower alkoxy and fluoro; phenyl and substituted phenyl wherein the substituent is chloro, bromo, fluoro, lower alkyl, lower alkoxy and trifluoromethyl; R6 is hydrogen, hydroxy, acetoxy and tertiary amino; AND N IS 0 OR AN INTEGER FROM 1 TO 8, AND INTERMEDIATES THEREFOR. Broad spectrum antibacterial agents; namely, Alpha (phosphonoalkyl)- and Alpha -( omega phosphonoalkyl)cycloalkylcephalosporins of the formula

Inventors

• 👤 Ernest S Hamanaka

Bibliographic Details