US3867447A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hydroxyguanidine O-carbamates
Assignee: EIDP Inc
•
Filing: 1973-06-25
•
Granted: 1975-02-18
•
Expires: 1993-06-25
Abstract
Abstract Disclosed herein are particular variously substituted 2hydroxyguanidine O-carbamates, useful as antihypertensive agents, made by reacting an hydroxyguanidine with an isocyanate. Exemplary is 1-methyl-1-n-propylhydroxyguanidine O-(N-methyl carbamate).
Inventors
- 👤 Saul Carl Cherkofsky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 09:18
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/155; C; C07; C07D; C07D317/00; C07D317/08; C07D317/44; C07D317/46; C07D317/48; C07D317/50; C07D317/58
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
37 words
UP TO ONE OF R1, R2 AND R3 IS SELECTED FROM (A) UP TO TWO OF R1, R2 AND R3 IS SELECTED FROM (B), AND UP TO ONE IF R1, R2 AND R3 IS SELECTED FROM (C),
Claim 2
Dependent Claim
37 words
UP TO ONE OF R1, R2 AND R3 IS SELECTED FROM (A) UP TO TWO OF R1, R2 AND R3 IS SELECTED FROM (B), AND UP TO ONE IF R1, R2 AND R3 IS SELECTED FROM (C),
Claim 3
Dependent Claim
5 words
A COMPOUND OF THE FORMULA
Claim 4
Dependent Claim
5 words
A COMPOUND OF THE FORMULA
Claim 5
Dependent Claim
16 words
WHEN R1, IS METHYL AND R2 IS HYDROGEN, R3 IS NOT UNSUBSTITUTED PHENYL OR UNSUBSTITUTED BENZYL,
Claim 6
Dependent Claim
16 words
WHEN R1, IS METHYL AND R2 IS HYDROGEN, R3 IS NOT UNSUBSTITUTED PHENYL OR UNSUBSTITUTED BENZYL,
Claim 7
Dependent Claim
16 words
when R1 is methyl and R2 is hydrogen, R3 is not unsubstituted phenyl or unsubstituted benzyl;
Claim 8
Dependent Claim
16 words
when R1 is methyl and R2 is hydrogen, R3 is not unsubstituted phenyl or unsubstituted benzyl;
Claim 9
Dependent Claim
26 words
A compound according to claim 1 wherein one of R1 and R2 is selected from (B), the other is selected from (C), and R3 is hydrogen.
Claim 10
Dependent Claim
14 words
when R1 is methyl and R3 is hydrogen, R2 is not unsubstituted phenyl; and
Claim 11
Dependent Claim
14 words
when R1 is methyl and R3 is hydrogen, R2 is not unsubstituted phenyl; and
Claim 12
Dependent Claim
19 words
A compound according to claim 1 wherein R1 and R2 are each selected from (B) and R3 is hydrogen.
Claim 13
Dependent Claim
14 words
WHEN R1 IS METHYL AND R3 IS HYDROGEN, R2 IS NOT UNSUBSTITUTED PHENYL, AND
Claim 14
Dependent Claim
14 words
WHEN R1 IS METHYL AND R3 IS HYDROGEN, R2 IS NOT UNSUBSTITUTED PHENYL, AND
Claim 15
Dependent Claim
31 words
WHEN ONE OF R1, R2 AND R3 IS HYDROGEN AND THE OTHER TWO R GROUPS ARE SELECTED FROM (B), THE TOTAL CARBON ATOMS IN THE SAID OTHER TWO GROUPS IS 3-9.
Claim 16
Dependent Claim
31 words
WHEN ONE OF R1, R2 AND R3 IS HYDROGEN AND THE OTHER TWO R GROUPS ARE SELECTED FROM (B), THE TOTAL CARBON ATOMS IN THE SAID OTHER TWO GROUPS IS 3-9.
Claim 17
Dependent Claim
28 words
A compound according to claim 1 wherein R1 or R2 is selected from (B), the other of R1 or R2 is hydrogen and R3 is selected from (B).
Claim 18
Dependent Claim
31 words
when one of R1, R2 and R3 is hydrogen and the other two R groups are selected from (B), the total carbon atoms in the said other two groups is 3-9.
Claim 19
Dependent Claim
31 words
when one of R1, R2 and R3 is hydrogen and the other two R groups are selected from (B), the total carbon atoms in the said other two groups is 3-9.
Claim 20
Dependent Claim
11 words
A compound according to claim 1 which is 1-methyl-1-p-fluorobenzylhydroxyguanidine 0-(N-methyl carbamate).
Claim 21
Dependent Claim
11 words
A compound according to claim 1 which is 1-methyl-1-p-chlorobenzylhydroxyguanidine 0-(N-methyl carbamate).
Claim 22
Dependent Claim
11 words
A compound according to claim 1 which is 1-methyl-1-p-nitrobenzylhydroxyguanidine 0-(N-methyl carbamate).
Claim 23
Dependent Claim
11 words
A compound according to claim 1 which is 1-methyl-1-i-butylhydroxyguanidine 0-(N-methyl carbamate).
Claim 24
Dependent Claim
11 words
A compound according to claim 1 which is 1-ethyl-1-phenylhydroxyguanidine 0-(N-methyl carbamate).
Claim 25
Dependent Claim
11 words
A compound according to claim 1 which is 1-n-propyl-1-phenylhydroxyguanidine 0-(N-methyl carbamate).
Claim 26
Dependent Claim
11 words
A compound according to claim 1 which is 1,1-di-n-propylhydroxyguanidine 0-(N-methyl carbamate).
Claim 27
Dependent Claim
11 words
A compound according to claim 1 which is 1-methyl-1-benzylhydroxyguanidine 0-(N-methyl carbamate).
References Cited (Backward Citations)
US3217037A
Cited
US3742056A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-02-17 | 1978-08-19 | 1979-02-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-02-17 | 1982-08-19 | 1983-02-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-02-17 | 1986-08-19 | 1987-02-18 | $7700.00 | Window Closed / Lapsed |