US3867375A
Expired / Lapsed
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Reagents for preparing and method of preparing prostaglandins
Assignee: Syntex USA LLC
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Filing: 1972-05-12
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Granted: 1975-02-18
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Expires: 1992-05-12
Abstract
Abstract Octenol ether copper(I) lithium reagents which are useful in preparing prostaglandin derivatives and methods of preparing such reagents and methods of preparing prostaglandin derivatives using such reagents. The prostaglandin derivatives exhibit prostaglandin-like pharmacological properties and thus are useful where such agents are indicated.
Inventors
- 👤 Francisco S Alvarez
- 👤 Arthur F Kluge
- 👤 John H Fried
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 07:24
CPC Classifications
C; C07; C07F; C07F1/00; C07F1/08; C07C; C07C405/00; C07C45/00; C07C45/61; C07C45/63; C07D; C07D309/00; C07D309/02; C07D309/08; C07D309/10; C07D309/12
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
16 words
A process for preparing prostaglandins and prostaglandin derivatives which comprises treating a compound having the formula:
Claim 2
Dependent Claim
16 words
A process for preparing prostaglandins and prostaglandin derivatives which comprises treating a compound having the formula:
Claim 3
Dependent Claim
24 words
The process of claim 1 wherein said treatment is conducted at a temperature of about -78*C for about from 20 minutes to 4 hours.
Claim 4
Dependent Claim
16 words
A PROCESS FOR PREPARING PROSTAGLANDINS AND PROSTAGLANDIN DERIVATIVES WHICH COMPRISES TREATING A COMPOUND HAVING THE FORMULA
Claim 5
Dependent Claim
16 words
A PROCESS FOR PREPARING PROSTAGLANDINS AND PROSTAGLANDIN DERIVATIVES WHICH COMPRISES TREATING A COMPOUND HAVING THE FORMULA
Claim 6
Dependent Claim
16 words
A process for preparing prostaglandins and prostaglandin derivatives which comprises treating a compound having the formula:
Claim 7
Dependent Claim
16 words
A process for preparing prostaglandins and prostaglandin derivatives which comprises treating a compound having the formula:
Claim 8
Dependent Claim
16 words
A process for preparing prostaglandins and prostaglandin derivatives which comprises treating a compound having the formula:
Claim 9
Dependent Claim
16 words
A process for preparing prostaglandins and prostaglandin derivatives which comprises treating a compound having the formula:
Claim 10
Dependent Claim
11 words
The process of claim 5 wherein said complexing reagent is tetramethylethylenediamine.
Claim 11
Dependent Claim
12 words
The process of claim 5 wherein said complexing reagent is trimethyl phosphIte.
Claim 12
Dependent Claim
16 words
A process for preparing prostaglandins and prostaglandin derivatives which comprises treating a compound having the formula:
Claim 13
Dependent Claim
16 words
A process for preparing prostaglandins and prostaglandin derivatives which comprises treating a compound having the formula:
Claim 14
Dependent Claim
11 words
The process of claim 8 wherein said complexing reagent is tetramethylethylenediamine.
Claim 15
Dependent Claim
12 words
The process of claim 8 wherein said complexing reagent is trimethyl phosphite.
Claim 16
Dependent Claim
14 words
A process for preparing prostaglandin derivatives which comprises treating a compound having the formula:
Claim 17
Dependent Claim
14 words
A process for preparing prostaglandin derivatives which comprises treating a compound having the formula:
Claim 18
Dependent Claim
14 words
A process for preparing prostaglandin derivatives which comprises treating a compound having the formula:
Claim 19
Dependent Claim
14 words
A process for preparing prostaglandin derivatives which comprises treating a compound having the formula:
Claim 20
Dependent Claim
14 words
A process for preparing prostaglandin derivatives which comprises treating a compound having the formula:
Claim 21
Dependent Claim
14 words
A process for preparing prostaglandin derivatives which comprises treating a compound having the formula:
Claim 22
Dependent Claim
14 words
A process for preparing prostaglandin derivatives which comprises treating a compound having the formula:
Claim 23
Dependent Claim
14 words
A process for preparing prostaglandin derivatives which comprises treating a compound having the formula:
Claim 24
Dependent Claim
29 words
The process of claim 13 wherein R2 is tetrahydropyranyl-2''-oxy and R3 is methyl; and in step (a) the alkyl lithium is n-butyl lithium and the iodooctenol ether is (S)-1-iodo-3-(2''-methoxyprop-2''-oxy)-trans-1-octene.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-02-17 | 1978-08-19 | 1979-02-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-02-17 | 1982-08-19 | 1983-02-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-02-17 | 1986-08-19 | 1987-02-18 | $7700.00 | Window Closed / Lapsed |