US3865857A
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Tri-substituted aluminum salts or di-substituted aluminum salts of carboxyl group-containing, pharmaceutically effective compounds, and process for preparation thereof
Assignee: Aska Pharmaceutical Co Ltd
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Filing: 1972-03-20
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Granted: 1975-02-11
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Expires: 1992-03-20
Abstract
Abstract A process for the preparation of di- or tri-substituted aluminum salts of carboxyl group-containing, pharmaceutically effective compounds which comprises reacting up to three types of carboxyl group-containing, pharmaceutically effective compounds with an organic aluminum compound expressed by the following formula; D R A W I N G WHEREIN R1 and R2, which may be the same or different, stand for an aliphatic alicyclic or aromatic hydrocarbon residue having up to 10 carbon atoms, and R3 stands for a hydrocarbon residue as defined with respect to R1 and R2, which may be the same as, or different from, R1 and R2, or a hydrocarbyloxy group of the formula OR4 in which R4 is an aliphatic, alicyclic or aromatic hydrocarbon residue having up to 10 carbon atoms, AND A NOVEL DI-OR TRI-SUBSTITUTED ALUMINUM SALTS OF CARBOXYL GROUP-CONTAINING, PHARMACEUTICALLY EFFECTIVE COMPOUNDS.
Inventors
- 👤 Yasushi Suzuki
- 👤 Toshihisa Itaya
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 08:10
CPC Classifications
C; C07; C07F; C07F5/00; C07F5/06; C07F5/069
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
18 words
A PROCESS FOR THE PREPARATION OF ALUMINUM SALTS OF CARBOXYL GROUP-CONTAINING, PHARMACEUTICALLY EFFECTIVE COMPOUNDS EXPRESSED BY THE FORMULA:
Claim 2
Dependent Claim
18 words
A PROCESS FOR THE PREPARATION OF ALUMINUM SALTS OF CARBOXYL GROUP-CONTAINING, PHARMACEUTICALLY EFFECTIVE COMPOUNDS EXPRESSED BY THE FORMULA:
Claim 3
Dependent Claim
17 words
The process of claim 1, wherein the reaction is carried out at a temperature below room temperature.
Claim 4
Dependent Claim
53 words
The process of claim 1, wherein said organic aluminum compound is one in which R1, R2 and R3, which mAy be the same or different, represent a straight or branched alkyl group of 2 to 5 carbon atoms, a cycloalkyl group of 5 to 7 carbon atoms, or a phenyl or benzyl group.
Claim 5
Dependent Claim
68 words
The process of claim 1, wherein said organic aluminum compound is one in which R1 and R2, which may be the same or different, represent a straight or branched alkyl group of 2 to 5 carbon atoms, a cycloalkyl group of 5 to 7 carbon atoms, or a phenyl or benzyl group, and R3 is an alkoxy group having 2 to 5 carbon atoms in the alkyl portion.
Claim 6
Dependent Claim
14 words
The process of claim 1, wherein said inert gas is nitrogen, argon or helium.
Claim 7
Dependent Claim
16 words
The process of claim 1, wherein the reaction is carried out in an inert organic solvent.
Claim 8
Dependent Claim
13 words
The process of claim 5, wherein said inert organic solvent is an ether.
Claim 9
Dependent Claim
5 words
A monomer of aluminum tris(o-acetoxybenzoate).
Claim 10
Dependent Claim
5 words
A monomer of aluminum tris(o-acetoxybenzoate).
Claim 11
Dependent Claim
8 words
A monomer or salt of monohydroxy aluminum bis-(oacetoxybenzoate).
Claim 12
Dependent Claim
8 words
A monomer or salt of monohydroxy aluminum bis-(oacetoxybenzoate).
Claim 13
Dependent Claim
19 words
An aluminum tris-(N-(3''-trifluoromethylphenyl)anthranilate) low polymer produced by reacting N-(3''-trifluoromethylphenyl)-anthranilic acid with an organic aluminum compound expressed by the formula:
Claim 14
Dependent Claim
19 words
An aluminum tris-(N-(3''-trifluoromethylphenyl)anthranilate) low polymer produced by reacting N-(3''-trifluoromethylphenyl)-anthranilic acid with an organic aluminum compound expressed by the formula:
Claim 15
Dependent Claim
26 words
A monomer or low polymer of aluminum tris-(N-(2'', 3''-trifluoromethylphenyl)-anthranilate), with the proviso that the low polymer is obtained by polymerizing aluminum salt monomers through coordination bonds.
Claim 16
Dependent Claim
26 words
A monomer or low polymer of aluminum tris-(N-(2'', 3''-trifluoromethylphenyl)-anthranilate), with the proviso that the low polymer is obtained by polymerizing aluminum salt monomers through coordination bonds.
Claim 17
Dependent Claim
26 words
A monomer or low polymer of aluminum mono-(N-(3''trifluoromethylphenyl)-anthranilate) bis-(o-acetoxybenzoate), with the proviso that the low polymer is obtained by polymerizing aluminum salt monomers through coordination bonds.
Claim 18
Dependent Claim
26 words
A monomer or low polymer of aluminum mono-(N-(3''trifluoromethylphenyl)-anthranilate) bis-(o-acetoxybenzoate), with the proviso that the low polymer is obtained by polymerizing aluminum salt monomers through coordination bonds.
Claim 19
Dependent Claim
26 words
A monomer or low polymer of aluminum mono-(o-acetoxybenzoate) bis-(N-(3''-trifluoromethylphenyl)-anthranilate), with the proviso that the low polymer is obtained by polymerizing aluminum salt monomers through coordination bonds.
Claim 20
Dependent Claim
26 words
A monomer or low polymer of aluminum mono-(o-acetoxybenzoate) bis-(N-(3''-trifluoromethylphenyl)-anthranilate), with the proviso that the low polymer is obtained by polymerizing aluminum salt monomers through coordination bonds.
Claim 21
Dependent Claim
26 words
A monomer or low polymer of aluminum mono-(4-amino2-hydroxybenzoate) bis-(N-(3''-trifluoromethylphenyl)-anthranilate), with the proviso that the low polymer is obtained by polymerizing aluminum salt monomers through coordination bonds.
Claim 22
Dependent Claim
26 words
A monomer or low polymer of aluminum mono-(4-amino2-hydroxybenzoate) bis-(N-(3''-trifluoromethylphenyl)-anthranilate), with the proviso that the low polymer is obtained by polymerizing aluminum salt monomers through coordination bonds.
Claim 23
Dependent Claim
24 words
A low polymer of monohydroxy aluminum bis-(N-(3''trifluoromethylphenyl)-anthranilate), with the proviso that the low polymer is obtained by polymerizing aluminum salt monomers through coordination bonds.
Claim 24
Dependent Claim
24 words
A low polymer of monohydroxy aluminum bis-(N-(3''trifluoromethylphenyl)-anthranilate), with the proviso that the low polymer is obtained by polymerizing aluminum salt monomers through coordination bonds.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-02-10 | 1978-08-12 | 1979-02-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-02-10 | 1982-08-12 | 1983-02-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-02-10 | 1986-08-12 | 1987-02-11 | $7700.00 | Window Closed / Lapsed |