US3864384A
Expired / Lapsed
US
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Substituted phenylacetic acid compounds
Assignee: William H Rorer Inc
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Filing: 1970-05-05
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Granted: 1975-02-04
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Expires: 1990-05-05
Abstract
Abstract Certain substituted Alpha -halo and Alpha mercaptophenylacetic acids and substituted phenylacetic acids having in Alpha -position a sulfur-containing group, a cyano group, or an amino group, their substantially non-toxic esters, salts, and acid amides as well as 5-phenyl substituted 2-imino-4oxothiazolidines and 5-phenyl substituted 2,4-dioxothiazolidines have a high anti-inflammatory, analgesic, and antipyretic activity, low toxicity, and/or a favorable therapeutic index with minor or no side-effects. Preferred compounds of this invention are Alpha , m-dichloro-p-cyclohexylphenylacetic acids and its esters and salts.
Inventors
- 👤 Julius Diamond
- 👤 Norman J Santora
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 11:46
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/21; A61K31/27; A61K31/185; A61K31/19; A61K31/26; A61P; A61P25/00; A61P25/04; A61P29/00; C; C07; C07C; C07C205/00; C07C205/49; C07C205/56; C07C205/57; C07C205/59; C07C205/61; C07C229/00; C07C229/02; C07C229/34; C07C233/00; C07C233/01; C07C233/45; C07C233/46; C07C233/47; C07C255/00; C07C255/49; C07C255/57; C07C313/00; C07C313/08; C07C313/18; C07C313/26; C07C313/30; C07C317/00; C07C317/44; C07C323/00; C07C323/50; C07C323/51; C07C323/56; C07C327/00; C07C327/20; C07C327/32; C07C381/00; C07C381/02; C07C57/00; C07C57/52; C07C57/58; C07C57/62; C07D; C07D277/00; C07D277/02; C07D277/20; C07D277/32; C07D277/34; C07D277/54; C07C2601/00; C07C2601/12; C07C2601/14
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
19 words
A SUBSTITUTED PHENYLACETIC ACID COMPOUND SELECTED FROM THE GROUP CONSISTING OF A SUBSTITUTED PHENYACETIC ACID COMPOUND OF THE FORMULA
Claim 2
Dependent Claim
19 words
A SUBSTITUTED PHENYLACETIC ACID COMPOUND SELECTED FROM THE GROUP CONSISTING OF A SUBSTITUTED PHENYACETIC ACID COMPOUND OF THE FORMULA
Claim 3
Dependent Claim
18 words
The substituted phenylacetic acid compound of claim 1, said compound being the lower alkyl ester of said acid.
Claim 4
Dependent Claim
12 words
The substituted phencylacetic acid compound of claim 1, said compound being dextrorotary.
Claim 5
Dependent Claim
12 words
The substituted phenylacetic acid compound of claim 1, said compound being levorotary.
Claim 6
Dependent Claim
31 words
The substituted phenylacetic acid compound of claim 1, said compound being selected from the group consisting of an Alpha , m-dihalo-p-cycloalkylphenylacetic acid and its substantially non-toxic, pharmaceutically acceptable esters and salts.
Claim 7
Dependent Claim
15 words
The compound of claim 1, which is the sodium salt of Alpha , m-dichloro-p-cyclohexylphenylacetic acid.
Claim 8
Dependent Claim
10 words
The compound of claim 1, which is Alpha ,m-dichloro-p-cyclohexylphenylacetic acid.
Claim 9
Dependent Claim
12 words
The compound of claim 1, which is Alpha ,m-dichloro-p-cyclohexylphenylacetic acid ethyl ester.
Claim 10
Dependent Claim
14 words
The compound of claim 1, which is the diethylammonium salt of Alpha ,m-dichloro-p-cyclohexylphenyl-acetic acid.
Claim 11
Dependent Claim
19 words
A substituted phenylacetic acid compound selected from the group consisting of a substituted phenylacetic acid compound of the formula
Claim 12
Dependent Claim
19 words
A substituted phenylacetic acid compound selected from the group consisting of a substituted phenylacetic acid compound of the formula
Claim 13
Dependent Claim
10 words
The compound of claim 5 which is Alpha -bromo-m-chloro-p-cyclohexylphenylacetic acid.
Claim 14
Dependent Claim
10 words
The compound of claim 5 which is Alpha -chloro-m-bromo-p-cyclohexylphenylacetic acid.
Claim 15
Dependent Claim
14 words
The compound of claim 12 which is the diethyl-ammonium salt of Alpha -chloro-m-bromo-p-cyclohexylphenylacetic acid.
Claim 16
Dependent Claim
30 words
A substituted phenylacetic acid compound of claim 1, said compound being selected from the group consisting of an Alpha -halo-m-nitro-p-cycloalkylphenylacetic acid and its substantially non-toxic, pharmaceutically acceptable esters and salts.
Claim 17
Dependent Claim
7 words
The compound which is Alpha -chloro-m-nitro-p-cyclohexylphenylacetIc acid.
Claim 18
Dependent Claim
7 words
The compound which is Alpha -chloro-m-nitro-p-cyclohexylphenylacetIc acid.
Claim 19
Dependent Claim
27 words
The substituted phenylacetic acid compound selected from the group consisting of Alpha ,m-dichloro-p-cyclohexylphenylacetic acid, its pharmaceutically acceptable lower alkyl esters, alkali metal salts and di-lower alkyl-ammonium salts.
Claim 20
Dependent Claim
27 words
The substituted phenylacetic acid compound selected from the group consisting of Alpha ,m-dichloro-p-cyclohexylphenylacetic acid, its pharmaceutically acceptable lower alkyl esters, alkali metal salts and di-lower alkyl-ammonium salts.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-02-03 | 1978-08-05 | 1979-02-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-02-03 | 1982-08-05 | 1983-02-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-02-03 | 1986-08-05 | 1987-02-04 | $7700.00 | Window Closed / Lapsed |