US3864332A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of preparing {60 -aminobenzlpenicillin
Assignee: Individual
•
Filing: 1972-05-18
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Granted: 1975-02-04
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Expires: 1992-05-18
Abstract
Abstract A method for preparing Alpha -aminobenzylpenicillin consisting of acylating a derivative of 6-aminopenicillanic acid, for example from an acylal derivative having the general formula WHERE R'' is an alkyl C1-C4 group, an alkyl halide, aryl or aralkyl groups with an activated ester of N-substituted D(-) Alpha -amino phenylacetic acid having the general formula AND X is either hydrogen, or 2-pyrimidyl, in an organic solvent medium with subsequent hydrolysis.
Inventors
- 👤 Meri Solomonovna Rabinovich
- 👤 Leonard Sergeevich Povarov
- 👤 Galina Sergeevna Pavljuk
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 06:17
CPC Classifications
C; C07; C07D; C07D499/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
24 words
A METHOD FOR PREPARING A-AMINOBENZYLPENICILLIN COMPRISING REACTING AN ACYLAL DERIVATIVE OF 6-AMINOPENICILLINANIC ACID WITH AN ACTIVATED ESTER OF N-PROTECTED D(-)AAMINOPHENYLACETIC ACID HAVING THE FORMULA:
Claim 2
Independent Claim
24 words
A METHOD FOR PREPARING A-AMINOBENZYLPENICILLIN COMPRISING REACTING AN ACYLAL DERIVATIVE OF 6-AMINOPENICILLINANIC ACID WITH AN ACTIVATED ESTER OF N-PROTECTED D(-)AAMINOPHENYLACETIC ACID HAVING THE FORMULA:
Claim 3
Dependent Claim
19 words
A method as claimed in claim 1, in which the acylal derivative of the 6-aminopenicillanic acid has the formula
Claim 4
Dependent Claim
30 words
A method as claimed in claim 2, in which an acylal derivative of 6-aminopenicillanic acid obtained by reacting an Alpha , Beta -unsaturated ether selected from the group consisting of
Claim 5
Dependent Claim
16 words
A method as claimed in claim 1, in which a trialkylsilyl derivative having the general formula
Claim 6
Dependent Claim
17 words
A method as claimed in claim 1, in which methylene chloride is used as the organic solvent.
Claim 7
Dependent Claim
13 words
An acylal derivative of 6-aminopenicillanic acid wherein the acylal moiety has the formula
Claim 8
Dependent Claim
13 words
An acylal derivative of 6-aminopenicillanic acid wherein the acylal moiety has the formula
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-02-03 | 1978-08-05 | 1979-02-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-02-03 | 1982-08-05 | 1983-02-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-02-03 | 1986-08-05 | 1987-02-04 | $7700.00 | Window Closed / Lapsed |