US3864084A
Expired / Lapsed
US
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Method for measurement of oxygen content in blood and other liquids by oxygen inhibition of chemical reactions
Assignee: Individual
•
Filing: 1972-08-03
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Granted: 1975-02-04
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Expires: 1992-08-03
Abstract
Abstract Method for measuring the oxygen content of blood. The blood sample to be analyzed is mixed with a monomer solution and free radical initiated polymerization is induced and timed. Oxygen in the sample inhibits polymerization. The logarithm of the time required to polymerize is linearly proportional to the oxygen content of the sample. Liquids other than blood can be analyzed by the disclosed method.
Inventors
- 👤 M Judah Folkman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:42
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/4925; G01N31/00; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/102499; Y10T436/20; Y10T436/207497
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
80 words
A METHOD OF MEASURING THE OXYGEN CONTENT OF LIWUIDS COMPRISING THE STEPS OF: MIXING A TEST LIQUID CONTAINING OXYGEN WITH AN ACTIVATOR POLYMERIZATION REACTION THAT IS INHIBITED BY OXYGEN IN SAID POLYMERIZATION REACTION THAT IS INHIBITED BY OXYGEN IN SAID TEST LIQUID: ISOLATING SAID TEST LIQUID AND SAID ACTIVATOR LIQUID FROM ANY GAS PHASE DURING SAID MIXING STEP; AND TIMING SAID POLYMERIZATION REACTION TO DETERMINE THE AMOUNT OF OXYGEN INITIALLY PRESENT IN SAID TEST LIQUID AND CONSUMED DURING SAID REACTION.
Claim 2
Independent Claim
80 words
A METHOD OF MEASURING THE OXYGEN CONTENT OF LIWUIDS COMPRISING THE STEPS OF: MIXING A TEST LIQUID CONTAINING OXYGEN WITH AN ACTIVATOR POLYMERIZATION REACTION THAT IS INHIBITED BY OXYGEN IN SAID POLYMERIZATION REACTION THAT IS INHIBITED BY OXYGEN IN SAID TEST LIQUID: ISOLATING SAID TEST LIQUID AND SAID ACTIVATOR LIQUID FROM ANY GAS PHASE DURING SAID MIXING STEP; AND TIMING SAID POLYMERIZATION REACTION TO DETERMINE THE AMOUNT OF OXYGEN INITIALLY PRESENT IN SAID TEST LIQUID AND CONSUMED DURING SAID REACTION.
Claim 3
Dependent Claim
21 words
A method according to claim 1 including a degassing step for removing gases from said activator liquid before said mixing step.
Claim 4
Dependent Claim
20 words
A method according to claim 1 wherein the temperature of said liquids is regulated during said mixing and timing steps.
Claim 5
Dependent Claim
12 words
A method according to claim 1 where said test liquid is water.
Claim 6
Independent Claim
12 words
A method according to claim wherein said test liquid comprises a fluorocarbon.
Claim 7
Dependent Claim
22 words
A method according to claim 5 comprising an equilibratIng step to equilibrate said fluorocarbon with a gaseous atmosphere before said mixing step.
Claim 8
Dependent Claim
15 words
A method according to claim 1 wherein said timing step comprises a viscosity monitoring step.
Claim 9
Dependent Claim
35 words
A method according to claim 7 comprising the step of comparing the measure of time yielded by said timing step to a standard of comparison for determing the amount of oxygen in said test liquid.
Claim 10
Dependent Claim
17 words
A method according to claim 8 wherein said polymerization comprises gelation and said polymer is a gel.
Claim 11
Dependent Claim
23 words
A method according to claim 8 wherein said standard of comparison is a graph comprising a curve with upper and lower end points.
Claim 12
Dependent Claim
21 words
A method according to claim 10 wherein said upper end point is located by oximetery of a fully oxygenated blood sample.
Claim 13
Dependent Claim
20 words
A method according to claim 10 wherein said lower end point is located by oximetery of a physiological saline solution.
Claim 14
Dependent Claim
22 words
A method according to claim 8 wherein said test liquid comprises a monomer solution and said activator liquid comprises free radical ions.
Claim 15
Dependent Claim
13 words
A method according to claim 13 wherein said test liquid further comprises blood.
Claim 16
Dependent Claim
14 words
A method according to claim 14 wherein said test liquid further comprises an anticoagulant.
Claim 17
Dependent Claim
14 words
A method according to claim 15 wherein said test liquid further comprises a buffer.
Claim 18
Dependent Claim
27 words
A method according to claim 8 wherein said mixing step comprises mixing a reduction activator with said liquids for producing sulfate radical ions in said activator liquid.
Claim 19
Dependent Claim
26 words
A method according to claim 17 wherein said reduction activator comprises bisulfite and said monomer comprises a vinyl monomer and said activator liquid comprises persulfate ions.
Claim 20
Dependent Claim
26 words
A method according to claim 18 wherein said reduction activator comprises sodium bisulfite and said vinyl monomer is acrylamide and said activator liquid comprises ammonium persulfate.
Claim 21
Dependent Claim
11 words
A method according to claim 18 wherein said polymerization includea copolymerization.
Claim 22
Dependent Claim
13 words
A method according to claim 20 wherein said test liquid further comprises bisacrylamide.
Claim 23
Independent Claim
77 words
A method of measuring the oxygen content of liquids comprising the steps of: providing an oxygen containing test liquid and an activator liquid; degassifying said activator liquid; mixing said test liquid with said activator liquid to produce a polymer by a free radical initiated polymerization reaction that is inhibited by oxygen in said test liquid; and timing said polymerization reaction to determine the amount of oxygen initially present in said test liquid and consumed during said reaction.
Claim 24
Independent Claim
77 words
A method of measuring the oxygen content of liquids comprising the steps of: providing an oxygen containing test liquid and an activator liquid; degassifying said activator liquid; mixing said test liquid with said activator liquid to produce a polymer by a free radical initiated polymerization reaction that is inhibited by oxygen in said test liquid; and timing said polymerization reaction to determine the amount of oxygen initially present in said test liquid and consumed during said reaction.
Claim 25
Independent Claim
67 words
A method of measuring the oxygen content of fluorocarbons comprising the steps of: mixing a fluorocarbon test liquid containing oxygen with an activator liquid to produce a polymer by a free radical initiated polymerization reaction that is inhibited by oxygen in said test liquid; and timing said polymerization reaction to determine the amount of oxygen initially present in said fluorocarbon test liquid and consumed during said reaction.
Claim 26
Independent Claim
67 words
A method of measuring the oxygen content of fluorocarbons comprising the steps of: mixing a fluorocarbon test liquid containing oxygen with an activator liquid to produce a polymer by a free radical initiated polymerization reaction that is inhibited by oxygen in said test liquid; and timing said polymerization reaction to determine the amount of oxygen initially present in said fluorocarbon test liquid and consumed during said reaction.
Claim 27
Independent Claim
65 words
A method of measuring the oxygen content of water comprising the steps of: mixing a test sample of water with an activator liquid to produce a polymer by a free radical initiated polymerization reaction that is inhibited by oxygen in said test sample; and timing said polymerization reaction to determine the amount of oxygen initially present in said test sample and consumed during said reaction.
Claim 28
Independent Claim
65 words
A method of measuring the oxygen content of water comprising the steps of: mixing a test sample of water with an activator liquid to produce a polymer by a free radical initiated polymerization reaction that is inhibited by oxygen in said test sample; and timing said polymerization reaction to determine the amount of oxygen initially present in said test sample and consumed during said reaction.
Claim 29
Dependent Claim
21 words
A method according to claim 24 comprising the step of isolating said liquids from any gas phase during said mixing step.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-02-03 | 1978-08-05 | 1979-02-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-02-03 | 1982-08-05 | 1983-02-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-02-03 | 1986-08-05 | 1987-02-04 | $7700.00 | Window Closed / Lapsed |