US3862931A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Gitoxigen in-digitoxoside compounds and therapeutic compositions for combating cardiac insufficiency
Assignee: Roche Diagnostics GmbH
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Filing: 1974-03-11
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Granted: 1975-01-28
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Expires: 1994-03-11
Abstract
Abstract New gitoxigenin-digitoxoside compound of the formula WHEREIN R1 is alkyl of up to 3 carbon atoms, which can be substituted by alkoxy of up to 3 carbon atoms; R2 and R3, which can be the same or different, are hydrogen or alkyl of up to 3 carbon atoms, which can be substituted by alkoxy radicals of up to 3 carbon atoms; or R2 and R3 can together also represent an acetal or ketal grouping containing 2 to 10 carbon atoms; and Z is a valency bond or two digitoxose residues, are outstandingly effective in the oral therapy of cardiac insufficiency.
Inventors
- 👤 Fritz Kaiser
- 👤 Hans Joachim Lubs
- 👤 Wolfgang Schaumann
- 👤 Wolfgang Voigtlander
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 22:43
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/56; A61K31/58; A61K31/585; C; C07; C07J; C07J19/00
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
16 words
Compound as claimed in claim 1, wherein R1 is alkyl of up to 3 carbon atoms.
Claim 2
Dependent Claim
19 words
Compound as claimed in claim 1, wherein R1 is alkoxyalkyl of up to 3 carbon atoms per alkyl moiety.
Claim 3
Dependent Claim
10 words
Compound as claimed in claim 1, wherein R2 is hydrogen.
Claim 4
Dependent Claim
10 words
Compound as claimed in claim 1, wherein R3 is hydrogen.
Claim 5
Dependent Claim
16 words
Compound as claimed in claim 1, wherein R2 is alkyl of up to 3 carbon atoms.
Claim 6
Dependent Claim
16 words
Compound as claimed in claim 1, wherein R3 is alkyl of up to 3 carbon atoms.
Claim 7
Dependent Claim
10 words
Compound as claimed in claim 1, wherein R2 is alkoxyalkyl.
Claim 8
Dependent Claim
10 words
Compound as claimed in claim 1, wherein R3 is alkoxyalkyl.
Claim 9
Dependent Claim
22 words
Compound as claimed in claim 1, wherein R2 and R3, taken together, is an acetal grouping of up to 6 carbon atoms.
Claim 10
Dependent Claim
22 words
Compound as claimed in claim 1, wherein R2 and R3, taken together, is a ketal grouping of up to 6 carbon atoms.
Claim 11
Dependent Claim
12 words
Compound as claimed in claim 1, wherein Z is a valence bond.
Claim 12
Dependent Claim
12 words
Compound as claimed in claim 1, wherein Z represents two digitoxose residues.
Claim 13
Dependent Claim
9 words
Compound as claimed in claim 1, designated 16-O-methyl-3'', 4''-isopropylidene-gitoxigenin-digitoxoside.
Claim 14
Dependent Claim
9 words
Compound as claimed in claim 1, designated 16-O-methyl-3'', 4''-n-propylidene-gitoxigenin-digitoxoside.
Claim 15
Dependent Claim
9 words
Compound as claimed in claim 1, designated 16-O-methyl-15'', 16''-isopropylidene-gitoxin.
Claim 16
Dependent Claim
8 words
Compound as claimed in claim 1, designated 16-O-methyl-gitoxigenin-digitoxoside.
Claim 17
Dependent Claim
8 words
Compound as claimed in claim 1, designated 16,3'',4''-trimethyl-gitoxigenin-digitoxoside.
Claim 18
Dependent Claim
8 words
Compound as claimed in claim 1, designated 16-O-methyl-gitoxin.
References Cited (Backward Citations)
US3514441A
Cited
US3531462A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-01-27 | 1978-07-29 | 1979-01-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-01-27 | 1982-07-29 | 1983-01-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-01-27 | 1986-07-29 | 1987-01-28 | $7700.00 | Window Closed / Lapsed |