US3857938A
Expired / Lapsed
US
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Method of preparing a novel antacid pharmaceutical product
Assignee: Rottapharm SpA
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Filing: 1973-04-13
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Granted: 1974-12-31
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Expires: 1993-04-13
Abstract
Abstract Preparing an antacid product by specifically associating aluminum hydroxide and basic Mg carbonate pentahydrate.
Inventors
- 👤 L Rovati
- 👤 G Picciola
- 👤 P Senin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 20:16
CPC Classifications
A; A61; A61K; A61K33/00; A61K33/06
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
208 words
A METHOD OF PREPARING A NOVEL ANTACID PHARMACEUTICAL PRODUCT FOR ORAL USE CHARACTERISED BY THE OPERATIONAL STEPS OF: A DISSOLVING IN WATER ALUMINUM SULPHATE HYDRATE AL2 (SO4)3. 18H2O IN A PROPORTION OF 1,400 - 4,00 ML WATER PER MOL SULPHATE; B. ADDING TO THE RESULTING SOLUTION WHILE STIRRING AQUEOUS AMMONIA OF A 27-30 PERCENT BY WEIGHT CONCENTRATION AT A POURING RATE OF 0.100-0.160 MOLES/MIN PER MOLE DISSOLVED SULPHATE, TILL A FINAL PH OF 9.75-9.81 IS REACHED, THEREBY UNIFORMLY DISPERSING ALUMINA HYDROXIDE AL(OH)3 IN GELATINOUS FORM; C. UNIFORMLY DISPERSING IN THE SAID DISPERSION BASIC MAGNESIUM CARBONATE PENTAHYDRATE (MGCO3)4.MG(OH)2.5H2O IN PARTICLES NOT EXCEEDING 50 MICRONS IN SIZE, IN A QUANTITY CORRESPONDING TO 1.0-1.2 ATOMS MG TO ONE ATOM AI PRESENT IN THE DISPERSION; D. FILTERING THE DISPERSION FROM STEP (C); E. REMOVING FROM THE FILTERING RESIDUE BY WASHING WITH WATER A PREPONDERANT PROPORTION OF THE AMMONIUM SULPHATE TRAPPED THEREIN AS A BY-PRODUCT OF STEP (B) F. REPLACING BY ACETONE AT LEAST 60 PERCENT BY WEIGHT OF THE WATER IMPREGNATING THE WASHED RESIDUE; G. DRYING THE ACETONE-IMPREGNATED RESIDUE AT A TEMPERATURE OF 60*-80*C TO OBTAIN A SOLID PARTICULATE PRODUCT CONTAINING LESS THAN 1 PERCENT BY WEIGHT IMBIBITION WATER H. MECHANICALLY REDUCING THE PRODUCT PARTICLES TO A SINE NOT EXCEEDING 10 MICRONS.
Claim 2
Independent Claim
208 words
A METHOD OF PREPARING A NOVEL ANTACID PHARMACEUTICAL PRODUCT FOR ORAL USE CHARACTERISED BY THE OPERATIONAL STEPS OF: A DISSOLVING IN WATER ALUMINUM SULPHATE HYDRATE AL2 (SO4)3. 18H2O IN A PROPORTION OF 1,400 - 4,00 ML WATER PER MOL SULPHATE; B. ADDING TO THE RESULTING SOLUTION WHILE STIRRING AQUEOUS AMMONIA OF A 27-30 PERCENT BY WEIGHT CONCENTRATION AT A POURING RATE OF 0.100-0.160 MOLES/MIN PER MOLE DISSOLVED SULPHATE, TILL A FINAL PH OF 9.75-9.81 IS REACHED, THEREBY UNIFORMLY DISPERSING ALUMINA HYDROXIDE AL(OH)3 IN GELATINOUS FORM; C. UNIFORMLY DISPERSING IN THE SAID DISPERSION BASIC MAGNESIUM CARBONATE PENTAHYDRATE (MGCO3)4.MG(OH)2.5H2O IN PARTICLES NOT EXCEEDING 50 MICRONS IN SIZE, IN A QUANTITY CORRESPONDING TO 1.0-1.2 ATOMS MG TO ONE ATOM AI PRESENT IN THE DISPERSION; D. FILTERING THE DISPERSION FROM STEP (C); E. REMOVING FROM THE FILTERING RESIDUE BY WASHING WITH WATER A PREPONDERANT PROPORTION OF THE AMMONIUM SULPHATE TRAPPED THEREIN AS A BY-PRODUCT OF STEP (B) F. REPLACING BY ACETONE AT LEAST 60 PERCENT BY WEIGHT OF THE WATER IMPREGNATING THE WASHED RESIDUE; G. DRYING THE ACETONE-IMPREGNATED RESIDUE AT A TEMPERATURE OF 60*-80*C TO OBTAIN A SOLID PARTICULATE PRODUCT CONTAINING LESS THAN 1 PERCENT BY WEIGHT IMBIBITION WATER H. MECHANICALLY REDUCING THE PRODUCT PARTICLES TO A SINE NOT EXCEEDING 10 MICRONS.
Claim 3
Dependent Claim
18 words
The method of claim 1, wherein the water proportion at step (a) is 1,500-2,000 ml per mole sulphate.
Claim 4
Dependent Claim
17 words
The method of claim 1 wherein the aqueous ammonia employed at step (b) is at 26 Be.
Claim 5
Dependent Claim
17 words
The method of claim 1, wherein the final pH value at step (b) is 9.79 to 9.81.
Claim 6
Dependent Claim
24 words
The method of claim 1, wherein the size of the particles of the basic magnesium carbonate at step (c) does not exceed 15 microns.
Claim 7
Dependent Claim
41 words
The method of claim 1, wherein replacement by acetone is effected by distempering the product from step (e) with an acetone quantity equalling 2 times at least by weight the water impregnating the product and thereafter removing the excess aqueous acetone.
Claim 8
Dependent Claim
205 words
An antacid for oral use obtained by the method comprising the steps of: a. dissolving in water aluminum sulphate hydrate Al2 (SO4)3. .18H2O in a proportion of 1,400 - 4,000 ml water per mole sulphate; b. adding to the resulting solution while stirring aqueous ammonia of a 27-30 percent by weight concentration at a pouring rate of 0.100-0.160 moles/min per mole dissolved sulphate, till a final pH of 9.75-9.81 is reached, thereby uniformly dispersing aluminum hydroxide Al(OH)3 in a gelatinous form; c. uniformly dispersing in the said dispersion basic magnesium carbonate pentahydrate (MgCO3)4.Mg(OH)2. 5H2O in particles not exceeding 50 microns in size, in a quantity corresponding to 1.0-1.2 atoms Mg to one atom Al present in the dispersion; d. filtering the dispersion from step (c); e. removing from the filtering residue by washing with water a preponderant proportion of the ammonium sulphate trapped therein as a by-product of step (b); f. replacing by acetone at least 60 percent by weight of the water impregnating the washed residue; g. drying the acetone-impregnated residue at a temperature of 60*-80*C to obtain a solid particulate product containing less than 1 percent by weight imbibition water; h. mechanically reducing the product particles to a size not exceeding 10 microns.
Claim 9
Dependent Claim
205 words
An antacid for oral use obtained by the method comprising the steps of: a. dissolving in water aluminum sulphate hydrate Al2 (SO4)3. .18H2O in a proportion of 1,400 - 4,000 ml water per mole sulphate; b. adding to the resulting solution while stirring aqueous ammonia of a 27-30 percent by weight concentration at a pouring rate of 0.100-0.160 moles/min per mole dissolved sulphate, till a final pH of 9.75-9.81 is reached, thereby uniformly dispersing aluminum hydroxide Al(OH)3 in a gelatinous form; c. uniformly dispersing in the said dispersion basic magnesium carbonate pentahydrate (MgCO3)4.Mg(OH)2. 5H2O in particles not exceeding 50 microns in size, in a quantity corresponding to 1.0-1.2 atoms Mg to one atom Al present in the dispersion; d. filtering the dispersion from step (c); e. removing from the filtering residue by washing with water a preponderant proportion of the ammonium sulphate trapped therein as a by-product of step (b); f. replacing by acetone at least 60 percent by weight of the water impregnating the washed residue; g. drying the acetone-impregnated residue at a temperature of 60*-80*C to obtain a solid particulate product containing less than 1 percent by weight imbibition water; h. mechanically reducing the product particles to a size not exceeding 10 microns.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-12-30 | 1978-07-01 | 1978-12-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-12-30 | 1982-07-01 | 1982-12-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-12-30 | 1986-07-01 | 1986-12-31 | $7700.00 | Window Closed / Lapsed |