US3856967A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Novel indoles in the treatment of pain
Assignee: Sanofi Aventis France
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Filing: 1972-07-17
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Granted: 1974-12-24
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Expires: 1992-07-17
Abstract
Abstract WHEREIN A is a divalent aliphatic hydrocarbon derived from a linear or branched alkyl, R is selected from the group consisting of cyclohexyl and an aromatic radical, R'' is selected from the group consisting of halogen, trifluoromethyl, lower alkyl, lower alkoxy and N,N-dilower-alkylamino and R1 is selected from the group consisting of hydrogen and lower alkyl and a cation of a nontoxic, therapeutically acceptable base which possess antiinflammatory and analgesic activity and their preparation. 1-CARBOXYALKYL-2-METHYL-INDOLES OF THE FORMULA
Inventors
- 👤 A Allais
- 👤 G Nomine
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 22:49
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/04; C07D209/10; C07D209/12; C07D209/08
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
53 words
A METHOD OF TREATING PAIN IN HUMANS WHICH COMPRISES ADMINISTERING TO HUMANS A SAFE AND ANALGESICALLY EFFECTIVE AMOUNT OF A COMPOUND SELECTED FROM THE GROUP CONSISTING OF (A) 1-(CARBOXYMETHYL)-2-METHYL-3-P-CHLOROBENZYL-6METHOXY-INDOLE, (B) 1-(CARBOXYMETHYL)-2-METHYL-3-PMETHOXY-BENZOYL-6-METHOXY-INDOLE, (C) 1(CARBOXYMETHOXY)-2-METHYL-3-P-FLUOROBENZOYL-6-METHOXYINDOLE, (D) 1-(A-CARBOXYETHYL)-2-METHYL-3-P-CHLOROBENZOYL6-CHLORO-INDOLE OR (E) 1-(A-CARBOXY-ETHYL)-2-METHYL-3-PFLUOROBENZOYL-6-CHLORO-INDOLE AND A LOWER ALKYL ESTER THEREOF AND SALT THEREOF WITH A NON-TOXIC, THERAPEUTICALLY ACCEPTABLE BASE.
Claim 2
Independent Claim
53 words
A METHOD OF TREATING PAIN IN HUMANS WHICH COMPRISES ADMINISTERING TO HUMANS A SAFE AND ANALGESICALLY EFFECTIVE AMOUNT OF A COMPOUND SELECTED FROM THE GROUP CONSISTING OF (A) 1-(CARBOXYMETHYL)-2-METHYL-3-P-CHLOROBENZYL-6METHOXY-INDOLE, (B) 1-(CARBOXYMETHYL)-2-METHYL-3-PMETHOXY-BENZOYL-6-METHOXY-INDOLE, (C) 1(CARBOXYMETHOXY)-2-METHYL-3-P-FLUOROBENZOYL-6-METHOXYINDOLE, (D) 1-(A-CARBOXYETHYL)-2-METHYL-3-P-CHLOROBENZOYL6-CHLORO-INDOLE OR (E) 1-(A-CARBOXY-ETHYL)-2-METHYL-3-PFLUOROBENZOYL-6-CHLORO-INDOLE AND A LOWER ALKYL ESTER THEREOF AND SALT THEREOF WITH A NON-TOXIC, THERAPEUTICALLY ACCEPTABLE BASE.
Claim 3
Dependent Claim
10 words
The method of claim 1 wherein the indole is 1-carboxymethyl-2-methyl-3-p-chlorobenzoyl-6-methoxy-indole.
Claim 4
Dependent Claim
10 words
The method of claim 1 wherein the indole is 1-carboxymethyl-2-methyl-3-p-methoxybenzoyl-6-methoxy-indole.
Claim 5
Dependent Claim
10 words
The method of claim 1 wherein the indole is 1-carboxymethyl-2-methyl-3-p-fluorobenzoyl-6-methoxy-indole.
Claim 6
Dependent Claim
12 words
The method of claim 1 wherein the indole is d1-1- Alpha -(carboxyethyl)-2-methyl-3-p-chlorobenzoyl-6-chloro-indole.
Claim 7
Dependent Claim
12 words
The method of claim 1 wherein the indole is d1-1- Alpha -(carboxyethyl)-2-methyl-3-p-fluorobenzoyl-6-chloro-indole.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-12-23 | 1978-06-24 | 1978-12-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-12-23 | 1982-06-24 | 1982-12-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-12-23 | 1986-06-24 | 1986-12-24 | $7700.00 | Window Closed / Lapsed |