L-({60 s,5s)-{60 -amino-3-chloro-2-isoxazoline-5-acetic acid
Abstract
Abstract Antibiotic AT-125, producible by culturing Streptomyces sviceus in an aqueous nutrient medium has the following structure: The absolute configuration of AT-125 was determined to be L-( Alpha S,5S)- Alpha -amino-3-chloro-2-isoxazoline-5-acetic acid. It is an amphoteric compound and can exist in different ionic forms according to the pH of the environment. At low pH, AT-125 exists in the acid-addition salt form, at a higher pH in a zwitterion form, and at a still higher pH in a metal salt form. AT-125 inhibits the growth of Bacillus subtilis, Saccharomyces pastorianus, Penicillium oxalicum, Candida albicans, Saccharomyces cerevisiae and Escherichia coli, and can be used to inhibit such microorganisms in various environments.
Inventors
- 👤 L Hanka
- 👤 D Martin
Bibliographic Details
Claims Analysis
Total Claims: 6References Cited (Backward Citations)
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