US3856783A
Expired / Lapsed
US
⏱️ 0.0 years remaining
8-oxa-3-azabi cyclo(3.2.1)octane compounds
Assignee: Zeneca Inc
•
Filing: 1973-06-14
•
Granted: 1974-12-24
•
Expires: 1993-06-14
Abstract
Abstract Disclosed are compounds, having the following general formula, which are useful as analgesics in living animals. (a) WHEREIN R is a radical selected from the group consisting of aralkyl, aryl, aminoalkyl, arylalkanoyl, heteroaroyl, alkoxy substituted aroyl, alkenyl (C2 to C4), halogen substituted araklyl, guanadinoalkyl, halogen substituted aroyl, alkyl substituted aroyl, halogen substituted arylalkanoyl, hexahydrobenzoyl, arylalkenoyl, o- and p-alkyl substituted phenylalkanoyl, alkyl substituted naphthylalkanoyl, alkanoyl (C3 to C20), haloalkyl substituted aroyl, alkoxy substituted aralkyl, heteroaralkyl, anilinocarbonyl, adamantanecarbonyl, arylsulfonyl, carboxyl substituted aroyl, hydroxyl substituted aroyl, alkanoyloxy substituted aroyl, arylglyoxylyl, alicyclic, arylene dicarbonyl-8-oxa-3-azabicyclo(3.2.1) octane, alkylene-8-oxa-3azabicyclo (3.2.1)octane, alkylene dicarbonyl-8-oxa-3azabicyclo(3.2.1)octane, and the pharmacologically acceptable acid addition salts thereof.
Inventors
- 👤 A Miller
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 22:10
CPC Classifications
C; C07; C07D; C07D307/00; C07D307/02; C07D307/04; C07D307/10; C07D307/12
Claims Analysis
Total Claims: 33
Claim 1
Independent Claim
6 words
A COMPOUND REPRESENTED BY THE FORMULA
Claim 2
Dependent Claim
6 words
A COMPOUND REPRESENTED BY THE FORMULA
Claim 3
Dependent Claim
6 words
A compound represented by the formula
Claim 4
Dependent Claim
6 words
A compound represented by the formula
Claim 5
Dependent Claim
75 words
A compound of claim 1 wherein R is a radical selected from the group consisting of benzyl, N-(hexamethylene)-8-oxa-3-azabicyclo(3.2.1)octane, phenyl, aminohexyl, phenylacetyl, quinoxaloyl, m-methoxybenzoyl, Alpha -methylphenethyl, aminoethyl, propenyl, Alpha -methyl p-chlorophenethyl, dimethylaminopropyl, phenethyl, 2-guanadinoethyl, p-chlorobenzoyl, m-chlorobenzoyl, o-chlorobenzoyl, m-chlorophenylacetyl, p-chlorophenylacetyl, N-(ethylene)18-oxa-3-azabicyclo(3.2.1)octane, Beta -methylphenethyl, Beta , Beta -dimethylphenethyl, p-chlorophenethyl, hexahydrobenzoyl, o-chlorophenylacetyl, cinnamoyl, phenethylcarbonyl, o-methylphenylacetyl, heptanoyl, m-trifluoromethylbenzoyl, p-methoxyphenethyl, Alpha -methylthienylethyl, anilinocarbonyl, adamantanecarbonyl, phenylsulfonyl, o-carboxybenzoyl, stearoyl, o-hydroxybenzoyl, nicotinoyl, o-acetoxybenzoyl, thenoyl, phenylglyoxylyl, cyclohexyl, 3,4-dimethoxyphenethyl, and thepharmacologically acceptable acid addition salts thereof.
Claim 6
Dependent Claim
9 words
a compound of claim 1 wherein R is m-methoxybenzoyl.
Claim 7
Dependent Claim
10 words
A compound of claim 1 wherein R is Alpha -methylphenethyl.
Claim 8
Dependent Claim
9 words
A compound of claim 1 wherein R is 1-propenyl.
Claim 9
Dependent Claim
11 words
A compound of claim 1 wherein R is Alpha -methyl p-chlorophenethyl.
Claim 10
Dependent Claim
12 words
A compound of claim 1 wherein R is o-, p-, or m-chlorobenzoyl.
Claim 11
Dependent Claim
12 words
A compound of claim 1 wherein R is o-, p-, or m-chlorophenylacetyl.
Claim 12
Dependent Claim
9 words
A compound of claim 1 wherein R is phenethylcarbonyl.
Claim 13
Dependent Claim
11 words
A compound of claim 1 wherein R is o- or p-methylphenylacetyl.
Claim 14
Dependent Claim
9 words
A compound of claim 1 wherein R is stearoyl.
Claim 15
Dependent Claim
8 words
A compound of claim 1 wherein R isphenethyl.
Claim 16
Dependent Claim
9 words
A compound of claim 1 wherein R is phenylacetyl.
Claim 17
Dependent Claim
9 words
A compound of claim 1 wherein R is aminoethyl.
Claim 18
Dependent Claim
9 words
A compound of claim 1 wherein R is thenoyl.
Claim 19
Dependent Claim
9 words
A compound of claim 1 wherein R is nicotinoyl.
Claim 20
Dependent Claim
9 words
A compound of claim 1 wherein R is N-(ethylene)-8-oxa-3-azabicyclo(3.2.1)Octane.
Claim 21
Dependent Claim
9 words
A compound of claim 1 wherein R is benzyl.
Claim 22
Dependent Claim
9 words
A compound of claim 1 wherein R is N-(hexamethylene)-8-oxa-3-azabicyclo(3.2.1)octane.
Claim 23
Dependent Claim
8 words
A compound of claim 1 wherein R isphenyl.
Claim 24
Dependent Claim
9 words
A compound of claim 1 wherein R is aminohexyl.
Claim 25
Dependent Claim
9 words
A compund of claim 1 wherein R is quinoxaloyl.
Claim 26
Dependent Claim
9 words
A compound of claim 1 wherein R is dimethylaminopropyl.
Claim 27
Dependent Claim
9 words
A compound of claim 1 wherein R is quanadinoethyl.
Claim 28
Dependent Claim
12 words
A compound of claim 1 wherein R is o-, p-, or m-chlorophenethyl.
Claim 29
Dependent Claim
9 words
A compound of claim 1 wherein R is hexahydrobenzoyl.
Claim 30
Dependent Claim
9 words
A compound of claim 1 wherein R is cinnamoyl.
Claim 31
Dependent Claim
9 words
A compound of claim 1 wherein R is heptanoyl.
Claim 32
Dependent Claim
12 words
A compound of claim 1 wherein R is o-, p-, or m-trifluoromethylbenzoyl.
Claim 33
Dependent Claim
12 words
A compound of claim 1 wherein R is Beta , Beta -dimethylphenethyl.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-12-23 | 1978-06-24 | 1978-12-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-12-23 | 1982-06-24 | 1982-12-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-12-23 | 1986-06-24 | 1986-12-24 | $7700.00 | Window Closed / Lapsed |