US3853923A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2-substituted-(2-hydroxy-3-lower alkaminopropoxy)-benzofurans
Assignee: Kaken Pharmaceutical Co Ltd
•
Filing: 1972-05-08
•
Granted: 1974-12-10
•
Expires: 1992-05-08
Abstract
Abstract Benzofuran derivatives of the general formula: AND THEIR PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS HAVING SUPERIOR PHARMACOLOGICAL ACTIVITIES FOR DISEASES IN CIRCULATORY SYSTEM OR PERIPHERAL NERVOUS SYSTEM, AND METHOD FOR THE PREPARATION OF THE SAID BENZOFURAN DERIVATIVES.
Inventors
- 👤 K Ito
- 👤 M Ikemoto
- 👤 K Kimura
- 👤 T Nakanishi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 08:30
CPC Classifications
C; C07; C07D; C07D307/00; C07D307/77; C07D307/78; C07D307/79; C07D307/80; C07D307/81; C07D307/86
Claims Analysis
Total Claims: 49
Claim 1
Independent Claim
6 words
A BENZOFURAN DERIIVATIVE OF THE FORMULA:
Claim 2
Dependent Claim
6 words
A BENZOFURAN DERIIVATIVE OF THE FORMULA:
Claim 3
Dependent Claim
4 words
2-acetyl-7-(2-hydroxy-3-tert.-butylaminopropoxy)benzofuran and its hydrochloride;
Claim 4
Dependent Claim
4 words
2-acetyl-7-(2-hydroxy-3-tert.-butylaminopropoxy)benzofuran and its hydrochloride;
Claim 5
Dependent Claim
18 words
A benzofuran derivative according to claim 1, wherein R is branched alkyl having 3 to 4 carbon atoms.
Claim 6
Dependent Claim
11 words
A benzofuran derivative according to claim 1, wherein A is -COR''.
Claim 7
Dependent Claim
4 words
2-acetyl-4-(2-hydroxy-3-tert.-butylaminopropoxy)benzofuran and its hydrochloride;
Claim 8
Dependent Claim
4 words
2-acetyl-4-(2-hydroxy-3-tert.-butylaminopropoxy)benzofuran and its hydrochloride;
Claim 9
Dependent Claim
4 words
2-carbethoxy-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran and its hydrochloride;
Claim 10
Dependent Claim
4 words
2-carbethoxy-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran and its hydrochloride;
Claim 11
Dependent Claim
1 words
2-acetyl-7-(2-hydroxy-3-isopropylaminopropyl)benzofuran.
Claim 12
Dependent Claim
1 words
2-acetyl-7-(2-hydroxy-3-isopropylaminopropyl)benzofuran.
Claim 13
Dependent Claim
2 words
2-acetyl-7-(2-hydroxy-3-tertiary butylaminopropoxy)benzofuran.
Claim 14
Dependent Claim
2 words
2-acetyl-7-(2-hydroxy-3-tertiary butylaminopropoxy)benzofuran.
Claim 15
Dependent Claim
1 words
2-benzoyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran;
Claim 16
Dependent Claim
1 words
2-benzoyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran;
Claim 17
Dependent Claim
2 words
2-acetyl-5-(2-hydroxy-3-isopropylaminopropoxy)benzofuran hydrochloride;
Claim 18
Dependent Claim
2 words
2-acetyl-5-(2-hydroxy-3-isopropylaminopropoxy)benzofuran hydrochloride;
Claim 19
Dependent Claim
1 words
2-carbethoxy-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran.
Claim 20
Dependent Claim
1 words
2-carbethoxy-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran.
Claim 21
Dependent Claim
1 words
2-benzoyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran.
Claim 22
Dependent Claim
1 words
2-benzoyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran.
Claim 23
Dependent Claim
1 words
2-acetyl-7-(2-hydroxy-sec.-butylaminopropoxy)benzofuran;
Claim 24
Dependent Claim
1 words
2-acetyl-7-(2-hydroxy-sec.-butylaminopropoxy)benzofuran;
Claim 25
Dependent Claim
1 words
2-acetyl-3-(2-hydroxy-3-tert.-butylaminopropoxy)benzofuran;
Claim 26
Dependent Claim
1 words
2-acetyl-3-(2-hydroxy-3-tert.-butylaminopropoxy)benzofuran;
Claim 27
Dependent Claim
2 words
2-acetyl-7-(2-hydroxy-3-secondary butylaminopropoxy)benzofuran.
Claim 28
Dependent Claim
2 words
2-acetyl-7-(2-hydroxy-3-secondary butylaminopropoxy)benzofuran.
Claim 29
Dependent Claim
2 words
2-acetyl-4-(2-hydroxy-3-tertiary butylaminopropoxy)benzofuran.
Claim 30
Dependent Claim
2 words
2-acetyl-4-(2-hydroxy-3-tertiary butylaminopropoxy)benzofuran.
Claim 31
Dependent Claim
2 words
2-acetyl-6-(2-hydroxy-3-tert.-butylaminopropoxy)benzofuran; and
Claim 32
Dependent Claim
2 words
2-acetyl-6-(2-hydroxy-3-tert.-butylaminopropoxy)benzofuran; and
Claim 33
Dependent Claim
1 words
2-acetyl-7-(2-hydroxy-3-n-propylaminopropoxy)benzofuran.
Claim 34
Dependent Claim
1 words
2-acetyl-7-(2-hydroxy-3-n-propylaminopropoxy)benzofuran.
Claim 35
Dependent Claim
1 words
2-(1-isopropylimino)ethyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran.
Claim 36
Dependent Claim
1 words
2-(1-isopropylimino)ethyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran.
Claim 37
Dependent Claim
1 words
2-(1-isopropylimino)ethyl-4-(2-hydroxy-3-isopropylaminopropoxy)benzofuran.
Claim 38
Dependent Claim
1 words
2-(1-isopropylimino)ethyl-4-(2-hydroxy-3-isopropylaminopropoxy)benzofuran.
Claim 39
Dependent Claim
7 words
A benzofuran derivative of the following formula:
Claim 40
Dependent Claim
7 words
A benzofuran derivative of the following formula:
Claim 41
Dependent Claim
30 words
The hydrochloride salt of the compound of claim 12 wherein R''CO is acetyl; R is isopropyl and the substituted propoxy group is on the 5 position of the benzofuran ring.
Claim 42
Dependent Claim
28 words
The benzofuran derivative of claim 12 wherein R''CO is acetyl; R is tertiary butyl and the substituted propoxy group is on the 3 position of the benzofuran ring.
Claim 43
Dependent Claim
28 words
The benzofuran derivative of claim 12 wherein R''CO is acetyl; R is tertiary butyl and the substituted propoxy group is on the 6 position of the benzofuran ring.
Claim 44
Dependent Claim
27 words
The benzofuran derivative of claim 12 wherein R''CO is acetyl; R is n-propyl and the substituted propoxy group is on the 7 position of the benzofuran ring.
Claim 45
Dependent Claim
9 words
The hydrochloride salt of the compound of claim 4.
Claim 46
Dependent Claim
9 words
The hydrochloride salt of the compound of claim 5.
Claim 47
Dependent Claim
9 words
The hydrochloride salt of the compound of claim 9.
Claim 48
Dependent Claim
9 words
The hydrochloride salt of the compound of claim 6.
Claim 49
Dependent Claim
12 words
The benzofuran derivative of claim 12 selected from the group consisting of:
References Cited (Backward Citations)
US3340266A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-12-09 | 1978-06-10 | 1978-12-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-12-09 | 1982-06-10 | 1982-12-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-12-09 | 1986-06-10 | 1986-12-10 | $7700.00 | Window Closed / Lapsed |