US3852455A
Expired / Lapsed
US
⏱️ 0.0 years remaining
4-{8 4({60 hydroxybenzyl)piperidino{9 -4-fluorobutyrophenone derivatives as tranquilizers
Assignee: Richardson Vicks Inc
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Filing: 1972-05-03
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Granted: 1974-12-03
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Expires: 1992-05-03
Abstract
Abstract Novel compounds which are neuroleptic agents useful as tranquilizers and having the formula WHEREIN R is hydrogen, halogen, such as chlorine, bromine or fluorine, alkyl having from 1 to 4 carbon atoms, alkoxy having from 1 to 4 carbon atoms, thioalkoxy having from 1 to 3 carbon atoms, trifluoromethyl, phenyl or phenoxy and may be attached to the phenyl ring in the ortho, meta or para position or pharmaceutically acceptable acid addition salts thereof. The novel compounds are produced by reacting (substituted) Alpha phenyl-4-piperidinemethanols or salts thereof with 4''-fluoro-4halobutyrophenones.
Inventors
- 👤 A Carr
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 19:57
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K31/445
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
32 words
A METHOD OF OBTAINING TRANSQUILIZING EFFECTS IN A PATIENT COMPRISING ADMINISTERING TO SAID PATIENT FROM 0.005 TO 10 MILLIGRAMS PER KILOGRAM OF BODY WEIGHT OF THE PATIENT A COMPOUND OF THE FORMULA
Claim 2
Independent Claim
32 words
A METHOD OF OBTAINING TRANSQUILIZING EFFECTS IN A PATIENT COMPRISING ADMINISTERING TO SAID PATIENT FROM 0.005 TO 10 MILLIGRAMS PER KILOGRAM OF BODY WEIGHT OF THE PATIENT A COMPOUND OF THE FORMULA
Claim 3
Dependent Claim
22 words
A method as claimed in claim 1 wherein said compound is 4''-fluoro-4-(4-(p-fluoro- Alpha -hydroxybenzyl)piperidino)butyrophenone or a pharmaceutically acceptable acid addition salt thereof.
Claim 4
Dependent Claim
22 words
A method as claimed in claim 1 wherein said compound is 4-(4-(p-chloro- Alpha -hydroxybenzyl)piperidino)-4''-fluorobutyrophenone or a pharmaceutically acceptable acid addition salt thereof.
Claim 5
Dependent Claim
22 words
A method as claimed in claim 1 wherein said compound is 4''-fluoro-4-(4-(p-methyl- Alpha -hydroxybenzyl)piperidino)butyrophenone or a pharmaceutically acceptable acid addition salt thereof.
Claim 6
Dependent Claim
22 words
A method as claimed in claim 1 wherein said compound is 4''-fluoro-4-(4-(p-methoxy- Alpha -hydroxybenzyl)piperidino)butyrophenone or a pharmaceutically acceptable acid addition salt thereof.
Claim 7
Dependent Claim
33 words
A method as claimed in claim 1 wherein said compound is administered in dosage units containing 0.5 to 25 milligrams of said compound in tablets which are taken 1 to 4 times daily.
Claim 8
Dependent Claim
20 words
A pharmaceutical composition comprising in unit dosage form, from about 0.5 to 25 milligrams of a compound of the formula
Claim 9
Dependent Claim
20 words
A pharmaceutical composition comprising in unit dosage form, from about 0.5 to 25 milligrams of a compound of the formula
References Cited (Backward Citations)
US3438991A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-12-02 | 1978-06-03 | 1978-12-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-12-02 | 1982-06-03 | 1982-12-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-12-02 | 1986-06-03 | 1986-12-03 | $7700.00 | Window Closed / Lapsed |