2-substituted-3-disubstituted-4,5,6,7-substituted or unsubstituted phthalimidines

Abstract

Abstract 1. A COMPOUND OF THE FORMULA, 1-(O=),2-R5,3-Q,3-Z,4-R4,5-R3,6-R2,7-R1-ISOINDOLIDINE WHERE R1 IS HYDROGEN, LOWER ALKOXY, HALO HAVING AN ATOMIC WEIGHT OF 19 TO 36, OR TRIFLUOROMETHYL, R2 IS HYDROGENM LOWER ALKYL, LOWER ALKOXY, HALO HAVING AN ATOMIC WEIGHT OF 19 TO 36, TRIFLUOROMETHYL, NITRO OR AMINO, R3 IS HYDROGEN, LOWER ALKYL, LOWER ALKOXY, HALO HAVING AN ATOMIC WEIGHT OF 19 TO 36, TRIFLUOROMETHYL, NITRO, AMINO, DIALKYLAMINO OR PHENYL, R4 IS HYDROGEN, LOWER ALKYL, LOWER ALKOXY, OR TRIFLUOROMETHYL, R5 IS HYDROGEN, LOWER ALKYL, PHENYL, ALLYL, BENZYL, HYDROXYETHYL, CARBAMOYLOXY, OR CARBETHOXYMETHYL, OR R1 AND R2 AND R3 AND R4, TOGETHER ARE METHYLENEDIOXY, Q IS -C(-R6)(-R7)-R8 WHERE R5 AND R6 ARE EACH INDEPENDENTLY METHYL OR ETHYL, OR R6 AND R7 TOGETHER ARE --(CH2)N-- WHERE N IS 4, 5, OR 6, R8 IS METHYL, VINYL OR ALLYL, OR -C(-CH3)=R9 WHERE R9 IS LOWER ALKYL, Z IS HYDROXY, AMINO, LOWER ALKOXY, OR -NH-CH2-CH2-N(-R10)-R11 WHERE R10 AND R11 ARE INDEPENTENTLY LOWER ALKYL, PROVIDED THAT (1) NO MORE THAN TWO OF R1, R2, R3 OR R4 ARE OTHER THAN HYDROGEN, (2) WHEN EITHER OF R1 AND R3 IS HALO, THE OTHER OF R1 OR R3 IS NOT HALO, (3) ONLY ONE OF R1 AND R3, OR R2 AND R4 IS ALKOXY AT ONE TIME, (4) THERE ARE NO TWO TRIFLUOROMETHYL GROUPS ON ADJACENT CARBON ATOMS, (5) ONLY ON OF R2 OR R3 IS NITRO OR AMINO, (6) WHEN Z IS HYDROXY AND Q IS T-BUTYL, THEN R1, R2, R3, R4 AND R5 ARE NOT HYDROGEN.

Inventors

• 👤 W Houlihan
• 👤 J Nadelson

Bibliographic Details