US3847138A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and system for controlled automated administration of drugs to patients
Assignee: Individual
•
Filing: 1973-03-14
•
Granted: 1974-11-12
•
Expires: 1993-03-14
Abstract
Abstract A method is provided for monitoring a characteristic of a patient, based upon radioactivity, such as the amount of radioactive drug in a patient''s system, and automatically attaining and maintaining a predetermined level of drug concentration in the patient, based on such monitoring. The system for carrying out such method includes monitoring means for monitoring radioactivity or level of radioactive drug previously administered to a patient, and administering additional radioactive drug to the patient based on such monitoring. The method and system of the invention is particularly applicable to the controlled automated administration of heparin to a patient.
Inventors
- 👤 S Gollub
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 22:45
CPC Classifications
A; A61; A61M; A61M5/00; A61M5/14; A61M5/168; A61M5/172; A61M5/1723; A61B; A61B5/00; A61B5/02; A61B5/026; A61B5/0275; A61B5/02755
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
53 words
A method for monitoring a characteristic of a patient and automatically administering a substance to the patient based on such monitoring, which comprises administering a radioactive substance to a patient, monitoring the radioactivity in said patient and automatically administering a therapeutic drug to the patient, said administering being directly responsive to said monitoring.
Claim 2
Independent Claim
53 words
A method for monitoring a characteristic of a patient and automatically administering a substance to the patient based on such monitoring, which comprises administering a radioactive substance to a patient, monitoring the radioactivity in said patient and automatically administering a therapeutic drug to the patient, said administering being directly responsive to said monitoring.
Claim 3
Dependent Claim
15 words
The method in accordance with claim 1 wherein said radioactive substance is said therapeutic drug.
Claim 4
Dependent Claim
20 words
The method in accordance with claim 2 wherein said radioactive substance is injected into the blood stream of a patient.
Claim 5
Dependent Claim
28 words
The method in accordance with claim 2 wherein the step of monitoring the radioactivity in the patient comprises continuously monitoring the blood stream of the patient for radioactivity.
Claim 6
Dependent Claim
14 words
The method in accordance with claim 1 wherein said radioactive substance is a radiopharmaceutical.
Claim 7
Dependent Claim
13 words
The method in accordance with claim 5 wherein said radiopharmaceutical is radioactive heparin.
Claim 8
Dependent Claim
44 words
The method in accordance with claim 1 wherein said monitoring step and said step for automatically administering a therapeutic drug to the patient are coordinated so as to maintain a predetermined level of radioactive drug concentration in a particular body portion of the patient.
Claim 9
Dependent Claim
110 words
The method in accordance with claim 7 wherein said monitoring step comprises sensing the blood stream of the patient for radioactivity which corresponds to the level of radioactive drug which was previously administered, and when said sensed radioactivity falls below a predetermined level, automatically activating means for administering additional radioactive drug to the patient thereby causing the level of radioactive drug to be increased to said predetermined level, and when said sensed radioactivity rises above a predetermined level, automatically deactivating said means for administering additional radioactive drug, thereby causing a leveling off of and subsequent fall of concentration of radioactive drug in the patient''s blood stream to said predetermined level.
Claim 10
Dependent Claim
14 words
The method in accordance with claim 8 wherein said radioactive drug is radioactive heparin.
Claim 11
Dependent Claim
15 words
The method in accordance with claim 9 wherein said radioactive heparin is S35 tagged heparin.
Claim 12
Dependent Claim
61 words
A system for carrying out the method as defined in claim 1, comprising, in combination, monitoring means for monitoring radioactivity in a patient, administering means in operative communication with said monitoring means and responsive to said monitoring means, for automatically administering a therapeutic substance to the patient, and means responsive to said monitoring means for controlling and activating said administering means.
Claim 13
Dependent Claim
41 words
The system in accordance with claim 11 wherein said administering means comprises infusion means, in communication with a supply of radioactive drug, for automatically feeding radioactive drug to a patient, and infusion conduit means linking said patient to said infusion means.
Claim 14
Dependent Claim
68 words
The system in accordance with claim 12, wherein said monitoring means comprises radioactivity sensing means, afferent fluid conduit means in communication with said sensing means and the patient, for passing a desired fluid from the patient to said sensing means, and control means linked to said sensing means and to said infusion means for automatically controlling said infusion means based on the radioactivity sensed by said sensing means.
Claim 15
Dependent Claim
33 words
The system in accordance with claim 13 including, in addiTion, efferent conduit means in communication with said sensing means and the patient, for passing fluid from said sensing means back to said patient.
Claim 16
Dependent Claim
33 words
The system in accordance with claim 13 including means to automatically shut down said infusion means when the level of radioactivity sensed by said sensing means is at or above a predetermined level.
Claim 17
Dependent Claim
44 words
The system in accordance with claim 15 including signal means in communication with said infusion means and/or said sensing means to notice to attending personnel that said infusion means is shut down and/or the level of radioactivity is at or above a predetermined level.
Claim 18
Dependent Claim
105 words
The system in accordance with claim 11 wherein said monitoring means comprises a radioactivity sensing element, one end of which including a sensing tip is adapted to be placed in a patient''s vein, and said administering means comprises infusion means in communication with a supply of radioactive drug, infusion conduit means, one end of which is placed in a patient''s vein, the other end of which is in communication with said infusion means, and also including control means in communication with said sensing element and said infusion means, for automatically controlling said infusion means based on the level of radioactivity sensed by said sensing element.
Claim 19
Dependent Claim
35 words
The system in accordance with claim 17 wherein said sensing tip of said sensing element is inserted in the patient''s vein upstream from the point at which said one end of said infusion conduit means.
Claim 20
Dependent Claim
35 words
The system in accordance with claim 11 wherein said monitoring means and administering means are coordinated so as to maintain a predetermined level of radioactive drug concentration in a particular body portion of the patient.
Claim 21
Dependent Claim
19 words
The system in accordance with claim 12 wherein said infusion means and said monitoring means are in miniaturized form.
Claim 22
Dependent Claim
19 words
The system in accordance with claim 13 wherein said infusion means and said monitoring means are in miniaturized form.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-11-11 | 1978-05-13 | 1978-11-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-11-11 | 1982-05-13 | 1982-11-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-11-11 | 1986-05-13 | 1986-11-12 | $7700.00 | Window Closed / Lapsed |