Treatment of hypercholesteremia

Claim 1

A METHOD OF TREATING PATIENTS SUFFERING FROM HYPERCHOLESTEREMIA WHICH COMPRISES THE DAILY ORAL ADMINISTRATION THERETO OF A HYPOCHOLESTEREMIC EFFECTIVE AMOUNT OF A COMPOSITION COMPRISING (A) A COMPOUND SELECTED FROM THE GROUP CONSISTING OF PARA-CHLOROPHENOXYISOBUTYRIC ACID, THE ETHYL ESTER O SAID ACID AND SALTS OF SAID ACID WITH PHARMACOLOGICALLY ACCEPTABLE METALS AND (B) A PHARMACOLOGICALLY ACCEPTABLE GRADE OF A SOLID NON-TOXIC ANION EXCHANGE RESIN IN THE WEIGHT RATIO OF 1:2 TO 1:20, SAID RESIN BEING SELECTED FROM THE GROUP CONSISTING OF (I) THE SOLID COPOLYMER OF DEXTRAN AND EPICHLOROHYDRIN HAVING FROM 10-35 PERCENT OF ITS WEIGHT OF HYDROXYL GROUPS, BASED UPON THE DRY SUBSTANCE, FROM 6-50 PERCENT OF SAID HYDROXYL GROUPS HAVING BEEN REPLACED BY GROUPS OF THE FORMULA RYO- IN WHICH Y IS AN ALKYLENE GROUP HAVING AT LEAST ONE BUT LESS THAN THREE CARBON ATOMS AND R IS A DIALKYLAMINO GROUP HAVING AT LEAST TWO BUT LESS THAN FIVE CARBON ATOMS, SAID COPOLYMER HAVING AN ION EXCHANGE CAPACITY OF 2-6 MILLIEQUIVALENTS PER GRAM OF DRY COMPOUND (II) THE SOLID COPOLYMER OF TETRAETHAYLENE PENTAMINE AND EPICHLOROHYDRIN WHICH HAS BEEN BROUGHT TO A PH OF APPROXIMATELY 4 AND THEN DRIED, AND (III) A SOLID STYRENE-DIVINYLBENZENE COPOLYMER CONTAINING NOT MORE THAN 5 PERCENT BY WEIGHT OF DIVINYL-BENZENE INTO WHICH MORE TERNARY ALKYLAMMONIUM GROUPS CONTAINING NOT MORE THAN 10 CARBON ATOMS HAVE BEEN INTRODUCED, WHICH COPOLYMER HAS AN EQUIVALENT WEIGHT, BASED UPON THE AMMONIUM GROUPS OF LESS THAN 500, SAID ANION EXCHANGE RESINS BEING ADMINISTERED IN AN OVERALL DAILY AMOUNT OF 3 TO 50 GRAMS.

Claim 2

A METHOD OF TREATING PATIENTS SUFFERING FROM HYPERCHOLESTEREMIA WHICH COMPRISES THE DAILY ORAL ADMINISTRATION THERETO OF A HYPOCHOLESTEREMIC EFFECTIVE AMOUNT OF A COMPOSITION COMPRISING (A) A COMPOUND SELECTED FROM THE GROUP CONSISTING OF PARA-CHLOROPHENOXYISOBUTYRIC ACID, THE ETHYL ESTER O SAID ACID AND SALTS OF SAID ACID WITH PHARMACOLOGICALLY ACCEPTABLE METALS AND (B) A PHARMACOLOGICALLY ACCEPTABLE GRADE OF A SOLID NON-TOXIC ANION EXCHANGE RESIN IN THE WEIGHT RATIO OF 1:2 TO 1:20, SAID RESIN BEING SELECTED FROM THE GROUP CONSISTING OF (I) THE SOLID COPOLYMER OF DEXTRAN AND EPICHLOROHYDRIN HAVING FROM 10-35 PERCENT OF ITS WEIGHT OF HYDROXYL GROUPS, BASED UPON THE DRY SUBSTANCE, FROM 6-50 PERCENT OF SAID HYDROXYL GROUPS HAVING BEEN REPLACED BY GROUPS OF THE FORMULA RYO- IN WHICH Y IS AN ALKYLENE GROUP HAVING AT LEAST ONE BUT LESS THAN THREE CARBON ATOMS AND R IS A DIALKYLAMINO GROUP HAVING AT LEAST TWO BUT LESS THAN FIVE CARBON ATOMS, SAID COPOLYMER HAVING AN ION EXCHANGE CAPACITY OF 2-6 MILLIEQUIVALENTS PER GRAM OF DRY COMPOUND (II) THE SOLID COPOLYMER OF TETRAETHAYLENE PENTAMINE AND EPICHLOROHYDRIN WHICH HAS BEEN BROUGHT TO A PH OF APPROXIMATELY 4 AND THEN DRIED, AND (III) A SOLID STYRENE-DIVINYLBENZENE COPOLYMER CONTAINING NOT MORE THAN 5 PERCENT BY WEIGHT OF DIVINYL-BENZENE INTO WHICH MORE TERNARY ALKYLAMMONIUM GROUPS CONTAINING NOT MORE THAN 10 CARBON ATOMS HAVE BEEN INTRODUCED, WHICH COPOLYMER HAS AN EQUIVALENT WEIGHT, BASED UPON THE AMMONIUM GROUPS OF LESS THAN 500, SAID ANION EXCHANGE RESINS BEING ADMINISTERED IN AN OVERALL DAILY AMOUNT OF 3 TO 50 GRAMS.