Complexes of double-stranded ribonucleic acid with polyquaternary amine

Abstract

Abstract WHEREIN EACH OF A AND B, INDEPENDENT OF THE OTHER IS AN INTEGER OF FROM 2 TO 6 AND X IS A NUMBER WHICH IS SUCH THAT THE AVERAGE MOLECULAR WEIGHT OF THE POLYCATION DIVIDED BY THE EQUIVALENT WEIGHT WHICH IS THE MOLECULAR WEIGHT OF THE POLYCATION DIVIDED BY THE VALUE (2X + 2) IS NOT GREATER THAN 98, AND THE ANIONS ARE EITHER (A) DOUBLESTRANDED RIBONUCLEIC ACID POLYANIONS, SAID DOUBLE-STRANDED RIBOUCLEIC ACID BEING OF NATURAL ORIGIN, OR )B) POLYANIONS OF A DOUBLE-STRANDED RIBONUCLEIC ACID OF NATURAL ORIGIN WHICH HAS BEEN SUBJECT TO CHEMICAL OR ENZYMATIC REACTION WHICH ALTERS THE PRIMARY AND/OR SECONDARY AND/OR TERTIARY STRUCTURE, PROVIDED THAT THE RESULTANT RIBONUCLEIC ACID RETAINS A SUBSTANTIAL DEGREE OF BASE PAIRING BETWEEN COMPLEMENTARY STRANDS, SAID ANTIVIRAL COMPLEX HAVING MORE THAN 60% OF THE ANIONIC SITES ON THE DOUBLE-STRANDED RIBOUNCLIC ACID ANIONS NEUTRALIZED BY THE QUATERNARY CATIONIC SITES ON THE QUATERNARY POLYMER. 1. AN ANTIVIRAL COMPLEX WHICH IS A PRINCIPALLY IONIC COMPLEX SOLUBLE IN 0.15 M AQUEOUS SODIUM CHLORIDE SOLUTION IN WHICH THE CATIONS ARE ORGAIC POLYMER POLYCATION HAVING A PLURALITY OF QUATERNARY NITROGEN SITES LOCATED AT INTERVALS ALONG THE POLYMER CHAINS, SAID POLYCATIONS HAVING THE FORMULA (H3C)2-N-(CH2)A-(N(+)(-CH3)2-(CH2)B-N(-CH3)2-(CH2)A)X- N(-CH3)2

Inventors

• 👤 M Harnden

Bibliographic Details