Anti-inflammatory compositions containing acylated-b-d-glucopyranosides and methods of using them
Abstract
Abstract Pharmaceutical compositions having anti-arthritic activity containing dosage units of compounds of the structural formula: WHEREIN X is halo, carbalkoxy to five carbons, acyloxy to five carbons, acylamido to 5 carbons, acylmercapto to five carbons, or aromatic hydrocarbons oxy to 10 carbons; Y is sulfur or oxygen; Z is -NH- or oxygen; R''s are one of aryl to eight carbons; alkyl to five carbons; and Alk is straight or branched chain alkyl up to five carbons, which may be substituted by alkyl, acyloxy or acylamido, as limited in defining X above. The preferred active ingredient of this invention, for example, are prepared by treating an 2-acylamido-2-deoxy-3,4,6-tri-0acetyl- Beta -D-glucopyranoside halide with an appropriate sulfhydryl agent, such as N-acetylcysteinamine, to form the corresponding 1-substituted analog.
Inventors
- 👤 B Sutton
Bibliographic Details
Claims Analysis
Total Claims: 5References Cited (Backward Citations)
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