Abstract 1. A METHOD OF PREPARING ONE OPTICALLY ACTIVE ENANTIOMORPH OF AN AMINO ACID FROM A SALT OF AN N-ACYL DERIVATIVE OF THE RACEMIC FORM OF SAID ACID WHICH COMPRISES: (A) CONTACTING SAID SALT IN AN AQUEOUS MEDIUM WITH AN EFFECTIVE AMOUNT OF ACYLASE UNTIL SAID ONE ENANTIOMORPH IS FORMED BY SAID ACYLASE SIMULTANEOUSLY WITH THE FORMING OF A CORRESPONDING AMOUNT OF THE SALT OF SAID ACYL DERIVATIVE OF THE OTHER ENANTIOMORPH OF SAID AMINO ACID; (B) CONTACTING SAID AQUEOUS MEDIUM CONTAINING SAID ACYLASE AND THE SALT OF SAID ACYL DERIVATIVE OF THE OTHER ENANTIMORPH WITH CRYSTALS OF THE SALT OF SAID ACYL DERIVATIVE OF SAID RACEMIC FORM UNTIL AN AMOUNT OF SALT OF SAID ACYL DERIVATIVE OF SAID ONE ANANTIOMORPH IS DISSOLVED FROM SAID CRYSTALS INTO SAID MEDIUM, AND THE RESIDUAL CRYSTALS ARE ENRICHED WITH THE SALT OF SAID ACYL DERIVATIVE OF SAID OTHER ENANTIOMORPH; AND (C) RECOVERING SAID ONE ENANTIOMORPH FROM SAID MEDIUM IN SUBSTANTIALLY PURE FORM, (1) THE SOLUBILITY IN WATER OF SAID SALT OF SAID ACYL DERIVATIVE OF THE RACEMIC FORM OF SAID AMINO ACID BEING GREATER THAN THE SOLUBILITIES OF SAID SALTS OF THE ACYL DERIVATIVES OF THE OPTICALLY ACTIVE ENANTIOMORPHS OF SAID AMINO ACID, (2) SAID ACYLASE BEING CAPABLE OF SELECTIVELY DEACYLATING SAID SALT OF SAID ACYL DERIVATIVE OF SAID OTHER ENANTIOMORPH, (3) THE BASE MOIETY OF SAID SALT BEING FREE OF DELETERIOUS INFLUENCE ON THE DEACYLATING EFFECT OF SAID ACYLASE.
A METHOD OF PREPARING ONE OPTICALLY ACTIVE ENANTIOMORPH OF AN AMINO ACID FROM A SALT OF AN N-ACYL DERIVATIVE OF THE RACEMIC FORM OF SAID ACID WHICH COMPRISES: (A) CONTACTING SAID SALT IN AN AQUEOUS MEDIUM WITH AN EFFECTIVE AMOUNT OF ACYLASE UNTIL SAID ONE ENANTIOMORPH IS FORMED BY SAID ACYLASE SIMULTANEOUSLY WITH THE FORMING OF A CORRESPONDING AMOUNT OF THE SALT OF SAID ACYL DERIVATIVE OF THE OTHER ENANTIOMORPH OF SAID AMINO ACID; (B) CONTACTING SAID AQUEOUS MEDIUM CONTAINING SAID ACYLASE AND THE SALT OF SAID ACYL DERIVATIVE OF THE OTHER ENANTIMORPH WITH CRYSTALS OF THE SALT OF SAID ACYL DERIVATIVE OF SAID RACEMIC FORM UNTIL AN AMOUNT OF SALT OF SAID ACYL DERIVATIVE OF SAID ONE ANANTIOMORPH IS DISSOLVED FROM SAID CRYSTALS INTO SAID MEDIUM, AND THE RESIDUAL CRYSTALS ARE ENRICHED WITH THE SALT OF SAID ACYL DERIVATIVE OF SAID OTHER ENANTIOMORPH; AND (C) RECOVERING SAID ONE ENANTIOMORPH FROM SAID MEDIUM IN SUBSTANTIALLY PURE FORM, (1) THE SOLUBILITY IN WATER OF SAID SALT OF SAID ACYL DERIVATIVE OF THE RACEMIC FORM OF SAID AMINO ACID BEING GREATER THAN THE SOLUBILITIES OF SAID SALTS OF THE ACYL DERIVATIVES OF THE OPTICALLY ACTIVE ENANTIOMORPHS OF SAID AMINO ACID, (2) SAID ACYLASE BEING CAPABLE OF SELECTIVELY DEACYLATING SAID SALT OF SAID ACYL DERIVATIVE OF SAID OTHER ENANTIOMORPH, (3) THE BASE MOIETY OF SAID SALT BEING FREE OF DELETERIOUS INFLUENCE ON THE DEACYLATING EFFECT OF SAID ACYLASE.
Claim 2
Independent Claim
235 words
A METHOD OF PREPARING ONE OPTICALLY ACTIVE ENANTIOMORPH OF AN AMINO ACID FROM A SALT OF AN N-ACYL DERIVATIVE OF THE RACEMIC FORM OF SAID ACID WHICH COMPRISES: (A) CONTACTING SAID SALT IN AN AQUEOUS MEDIUM WITH AN EFFECTIVE AMOUNT OF ACYLASE UNTIL SAID ONE ENANTIOMORPH IS FORMED BY SAID ACYLASE SIMULTANEOUSLY WITH THE FORMING OF A CORRESPONDING AMOUNT OF THE SALT OF SAID ACYL DERIVATIVE OF THE OTHER ENANTIOMORPH OF SAID AMINO ACID; (B) CONTACTING SAID AQUEOUS MEDIUM CONTAINING SAID ACYLASE AND THE SALT OF SAID ACYL DERIVATIVE OF THE OTHER ENANTIMORPH WITH CRYSTALS OF THE SALT OF SAID ACYL DERIVATIVE OF SAID RACEMIC FORM UNTIL AN AMOUNT OF SALT OF SAID ACYL DERIVATIVE OF SAID ONE ANANTIOMORPH IS DISSOLVED FROM SAID CRYSTALS INTO SAID MEDIUM, AND THE RESIDUAL CRYSTALS ARE ENRICHED WITH THE SALT OF SAID ACYL DERIVATIVE OF SAID OTHER ENANTIOMORPH; AND (C) RECOVERING SAID ONE ENANTIOMORPH FROM SAID MEDIUM IN SUBSTANTIALLY PURE FORM, (1) THE SOLUBILITY IN WATER OF SAID SALT OF SAID ACYL DERIVATIVE OF THE RACEMIC FORM OF SAID AMINO ACID BEING GREATER THAN THE SOLUBILITIES OF SAID SALTS OF THE ACYL DERIVATIVES OF THE OPTICALLY ACTIVE ENANTIOMORPHS OF SAID AMINO ACID, (2) SAID ACYLASE BEING CAPABLE OF SELECTIVELY DEACYLATING SAID SALT OF SAID ACYL DERIVATIVE OF SAID OTHER ENANTIOMORPH, (3) THE BASE MOIETY OF SAID SALT BEING FREE OF DELETERIOUS INFLUENCE ON THE DEACYLATING EFFECT OF SAID ACYLASE.