Penicillin conversion by halogen electrophiles and anti-bacterials derived thereby

Abstract

Abstract 1. A COMPOUND HAVING THE FORMULA 2-(R3-OOC-),3,3-DI(H3C-),4-Y,5-X,6-(R1-N(-R2)-)-PENAM WHEREIN R1 IS AN ACYL GROUP SELECTED FROM THE GROUP CONSISTING OF A GROUP OF THE FORMULA Q-PHENYL-(CH2)N-CO- WHEREIN Q IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND ONE OR MORE SUBSTITUENTS SELECTED FROM THE GROUP CONSISTING OF C1 TO C3 ALKYL, C1 TO C3 ALKOXY, NITRO, HALOGEN, AND TRIFLUOROMETHYL AND N IS ZERO OR AN INTEGER FROM 1 TO 5; A GROUP OF THE FORMULA Q-PHENYL-O-(CH2)N-CO- WHEREIN Q AND N ARE AS DEFINED ABOVE; A GROUP OF THE FORMULA Q-PHENYL-O-C(-CH3)2-CO- WHEREIN Q IS AS DEFINED ABOVE; AND, A GROUP OF THE FORMULA R4-CO- WHEREIN R4 IS HYDROGEN OR C1 TO C6 ALKYL; R2 IS HYDROGEN; OR, R1 AND R2, TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE BONDED DEFINE AN IMIDO GROUP SELECTED FROM THE GROUP CONSISTING OF PHTHALIMIDO AND SUCCINIMIDO; R3 IS SELECTED FROM THE GROUP CONSISTING OF C1-C4 ALKYYL, TRICHLOROETHYL, BENZYL, P-NITROBENXYL, P-METHOXYBENZYL, BENZHYDRYL, PHTHALIMIDOMETHYL AND PHENACYL; X IS SELECTED FROM THE GROUP CONSISTING OF CHLORO, AND C2-C6 ALKANOYLOXY; AND Y IS SELECTED FROM THE GROUP CONSISTING OF CHLORO, BROMO, N-BENZOTRIAZOLYL, AND SUCCINIMIDO.

Inventors

• 👤 S Kukolja

Bibliographic Details