Adenosine derivatives

Abstract

Abstract COMPOUNDS OF THE FORMULA 2-A,6-((2-R1,3,6-(-Y-)-CYCLOHEXYL)-Z-NH-),9-(3,4-DI(HO-), 5-(HO-CH2-)-TETRAHYDROFUR-2-YL)-9H-PURINE AND THE CYCLOHEX-4-ENYL COMPOUND WHEREIN A IS H, HALOEN, SR2, OR2, N(R2)2, NH-N(R2)2 OR N3; R1 IS CH2OH, ALKYL OR CYCLOALKYL OR UP TO 6 CARBON ATOMS, COOR2, FURYL, TETRAHYDROFURYL, THIENYL, A 5- OR 6-MEMBERED SATURATED OR UNSUBSTURATED RING CONTAINING ONE OR TWO NITROGEN ATOMS, OR UNSUBSTITUTED PHENYL OR PHENYL MONO-, DI- OR POLYSUBSTITUTED BY ONE OR MORE OR R2, HALOGEN ATOMS, OR UNSUBSTIOR NITRO OR MONOSUBSTITUTED BY ALKYLENEDIOXY; R2 IS H OR ALKYL OF UP TO 4 CARBON ATOMS; Y IS (-CH2)-M WHEREIN M IS THE INTEGER 1, 2 OR 3, AC IS THE ACYL RADICAL OF A CARBOXYLIC ACID OF UP TO 6 CARBON ATOMS; ABND Z IS (-CH2-)N WHEREIN N IS THE INTEGER 0, 1 OR 2; AND THE DOTTED LINE MEANS A DOUBLE BOND CAN BE PRESENT AT THAT POSITION OF THE MOLECULE, AND THE THERAPEUTICALLY ACCEPTABLE SALTS THEREOF POSSESS VALUABLE PHARMACOLOGICAL PROPERTIES. MORE SPECIFICALLY, THEY HAVE A FAVAOURABLE INFLUENCE ON THE TRANSPORT OF OXYGEN IN THE BLOOD, I.E. THEY POSSESS ONE OR MORE ACTIVITIES SELECTED FROM INCREASING THE CORONARY BLOOD FLOW, INCREASING THE OXYGEN PARTIAL PRESSURE IN THE CORONARY VENOUS BLOOD, AND IMPROVING THE CIRCULATION. ADDITIONALLY, THEY ARE EFFECTIVE ON THE LIPID METABOLISM, I.E. THEY POSSESS ONE OR MORE ACTIVITIES SELECTED FROM INHIBITING THE LIPOLYSIS, LOWERING THE LEVEL OF FATTY ACIDS, THE LEVEL OF TRIGLYCERIDES AND THE LEVEL OF CHOLESTEROL. ACCORDINGLY, THE COMPOUNDS CAN BE EMPLOYED AS PHARMACEUTICALS. FOR EXAMPLE, THEY ARE EFFECTIVE IN THE ENDOVASCULAR PAIN MODEL AND THUS MAY BE USED AGAINST THE PAIN ASSOCIATED WITH ANGINA PECTORIS. THEY MAY ALSO BE EMPLOYED IN THE TREATMENT OF ARTERIOSCLEROSIS AND HYPERLIPIDEMIA OF DIFFERENT ORGINS. THEY ARE ALSO USEFUL AS INTERMEDIATS FOR THE PREPARATION OF OTHER DRUGS AND/OR OTHER CHEMICAL COMPOUNDS.

Inventors

• 👤 W Mehrhof
• 👤 H Schliep
• 👤 R Pohlke
• 👤 R Jonas
• 👤 Z Simane
• 👤 K Becker
• 👤 H Nowak

Bibliographic Details