7-(3-substituted-1,2,4-oxadiazole-5-one-4-acetamido)cephalosporanic acids and derivatives thereof
Abstract
Abstract 6 - (N (SUBSTITUTED - IMIDOLYL)AMINOACETAMIDO)CEPHALOSPORANIC ACIDS AND THEIR SALTS AND THE CORRESPONDING BETAINES AND DESACETOXY DERIVATIVES ARE VALUABLE AS ANTIBACTERIAL AGENTS, IN POULTRY AND ANIMALS, INCLUDING MAN, THERAPEUTIC AGENTS IN POULTRY AND ANIMALS, INCLUDING MAN, AND ARE ESPECIALLY USEFUL IN THE TREATMENT OF INFECTIOUS DISEASES CAUSED BY GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA. 6 - (N - PHENYLACETIMIDOYL)AMINOACETAMIDO)CEPHALOSPORANIC ACID, A PREFERRRED EMBODIMENT OF THE INVENTION, IS PREPARED FOR EXAMPLE, BY RANEY NICKEL HYDROGENATION (50 P.S.I., R.T.) OF AN AQUEOUS SOLUTION OF SODIUM 7 - (3 - BENZYL - 1,2,4 - OXADIAZOLE - 5 - ONE - 4 - ACETAMIDO)CEPHALOSPORANATE WHICH IS PREPARED IN TURN BY REACTION OF 7 - AMINOCEPHALOSPORANIC ACID WITH 3 - BENZYL1,2,4-OXADIAZOLE-5-ONE-4-ACETYL CHLORIDE.
Inventors
- 👤 C Holdrege
Bibliographic Details
Claims Analysis
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| 3.5 Years (Year 4) | 1977-09-02 | 1978-03-04 | 1978-09-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-09-02 | 1982-03-04 | 1982-09-03 | $3760.00 | Window Closed / Lapsed |
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