Process for production of alkali metal salt of heparin
Abstract
Abstract HEPARIN-CONTAINING ANIMAL TISSUE, SUCH AS HOG MUCOSA, IS SUBJECTED TO DIGESTION ACTION IN AN AQUEOUS MEDIUM, TO PRODUCE A HEPARIN-CONTAINING DIGESTION EXTRACT AND THE HEPARIN RECOERY IS ACCOMPLISHED BY SELECTIVELY PASSING A LOW MOLECULAR WEIGHT FRACTION OF SAID DIGESTION EXTRACT THRU A SEMIPERMEABLE MEMBRANE TO PRODUCE AS A RESIDUUM A CONCENTRATE OF PROTEINS IN WHICH HEPARIN IS A COMPOENT. MUCOPOLYSACCGARUDE COMPLEXES CONSISTING PREDOMINANTLY OF HEPARRIN COMPLEX ARE PRECIPITATED FROM THE CONCENTRATE BY ADDITION OF A QUARTENARY AMMONIUM SALT. THE QUATERNARY AMMONIUM SALT COMPLEXES ARE DISSOLVED IN A SALT SOLUTION AND ETHYL ALCOHOL MIXED WITH THE SALT SOLUTION IN A VOLUME SUFFICIENT TO DISSOLVE THE QUATERNARY AMMONIUM SLAT COMPONENT AND THEREBY PRECIPITATE HEPARIN IN AN ALKALI METAL SALT FORM.
Inventors
- 👤 E Mancilla
- 👤 R Peting
- 👤 Ness L Van
Bibliographic Details
Claims Analysis
Total Claims: 0References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-06-17 | 1977-12-17 | 1978-06-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-06-17 | 1981-12-17 | 1982-06-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-06-17 | 1985-12-17 | 1986-06-18 | $7700.00 | Window Closed / Lapsed |